Factor V Leiden, protein C, and lipoprotein (a) in catheter-related thrombosis in childhood: A prospective study

Nowak‐Göttl, Ulrike; Dübbers, Angelika; Kececioglu, Deniz; Koch, Hans Georg; Kotthoff, S.; Runde, Judith; Vielhaber, H.

doi:10.1016/s0022-3476(97)70071-4

Cited by 125 publications

(96 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, we suggest that this difference in the aetiology of childhood PVT with respect to genetic prothrombotic risk factors is mainly as a result of the system of patient recruitment, different childhood age populations, and the inclusion or exclusion of catheter-related thrombosis that, in two prospective studies, has been shown not to be commonly associated with a risk of PVT in sick neonates (Schwartz et al, 1997;Guimaraes et al, 1998). Hepatic venous vascular occlusion in neonates and infants is rare and was not found in the previously reported ESPED survey (Nowak-Go Èttl et al, 1997b). In this newly recruited cohort of babies, 10 out of 65 infants affected presented with HVT, in one case associated with the homozygous FV G1691A mutation (which has also been reported in a baby with Budd±Chiari syndrome) (Gurakan et al, 1999).…”

Section: Risk Factorsmentioning

confidence: 91%

“…In contrast, thromboembolic disease is an infrequent event in childhood, with infants and adolescents at greatest risk (Andrew et al, 1994;Andrew, 1995). Neonatal thrombosis and vascular accidents within the first year of life are being increasingly diagnosed and, in the majority of cases, central venous lines are involved (Schmidt & Andrew, 1995;Nowak-Go Èttl et al, 1997a). During infancy, apart from catheter-related thrombosis, renal venous thrombosis (RVT), caval vein thrombosis, portal vascular occlusions (PVT) or hepatic vein thrombosis (HVT) have been reported, often associated with acquired predisposing factors such as peripartal asphyxia, septicaemia or maternal diabetes (Uttenreuther-Fischer et al, 1996;Farnoux et al, 1998;Bo Èkenkamp et al, 2000).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Heller

Schobeß²,

Kurnik³

et al. 2000

Br J Haematol

Self Cite

View full text Add to dashboard Cite

The factor V (FV) G1691A mutation, the prothrombin (PT) G20210A variant, the methylenetetrahydrofolate reductase (MTHFR) T677T genotype, together with fasting homocysteine (HCY) concentration, lipoprotein (Lp)(a), anti‐thrombin (AT), protein C (PC), protein S (PS) and anti‐cardiolipin antibodies were investigated in 65 consecutively recruited infants (neonate to < 12 months) with renal venous thrombosis (RVT; n = 31), portal vein thrombosis (PVT; n = 24) or hepatic vein thrombosis (HVT n = 10), and 100 age‐ and sex‐matched healthy controls. FV G1691A was found in 14 babies (heterozygous: RVT n = 9, PVT n = 4; homozygous HVT n = 1) and five controls, the MTHFR TT677 genotype together with increased HCY in four infants with thrombosis (RVT n = 2; PVT n = 1; HVT n = 1) compared with one control, and the PT G20210A variant was present in one control only. PC type I deficiency was diagnosed in three patients (RVT n = 2; PVT n = 1) and AT deficiency in two patients (RVT n = 1; PVT n = 1). Three neonates with spontaneous thrombosis showed FV G1691A combined with Lp(a) and the FV G1691A was combined with the PT G20210A genotype in two infants. Additional triggering factors were reported in 27 patients (41·5%). The overall odds ratios (ORs) and 95% confidence intervals (CIs) with respect to the different thrombosis locations were: RVT (OR/CI: 10·9/3·85–31·1; P < 0·0001), PVT (5·47/1·7–17·6; P < 0·0007) and HVT (3·3/0·58–18·7; P = 0·18). The data presented here suggest that genetic prothrombotic risk factors also play an important role in abdominal venous thrombosis during infancy.

show abstract

Section: Risk Factorsmentioning

confidence: 91%

mentioning

confidence: 99%

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Heller

Schobeß²,

Kurnik³

et al. 2000

Br J Haematol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Genetic prothrombotic factors are more prevalent in patients with spontaneous and catheter-associated thrombosis compared to the general population. 12,13 Factor V Leiden (FVL) is the most commonly identified risk factor 14 and has been associated with an increased incidence of both spontaneous and catheter-associated thrombosis. 12,[15][16][17] The risk of spontaneous thrombosis increases eightfold in the heterozygous state, and 80-fold in the homozygous state.…”

Section: Introductionmentioning

confidence: 99%

Genetic prothrombotic mutations are common in neonates but are not associated with umbilical catheter-associated thrombosis

et al. 2007

View full text Add to dashboard Cite

Objective: To evaluate the prevalence of hereditary prothrombotic mutations, and their effect on the incidence and severity of umbilical arterial or venous catheter (UAC or UVC)-associated thrombosis.Study Design: All neonates with a UAC or UVC were studied prospectively for the presence, severity and timing of thrombosis with duplex Doppler ultrasound scan. Genetic testing for factor V Leiden (FVL), prothrombin mutation (PTm) and methylene-tetrahydrofolate reductase (MTHFR) mutations was performed using PCR and restriction fragment length polymorphism assays.Result: Umbilical catheter (UC)-associated thrombosis developed in 16/53 (31%) neonates; 23% of UACs and 22% of UVCs were associated with thrombosis. The prevalence of a significant prothrombotic mutation was present in 10/51 (20%) of infants: FVL (8%), MTHFR667 homozygosity (10%), MTHFR1298 homozygosity (2%) and PTm (0%). There was no increase in the risk of UC-associated thrombus in patients carrying these prothrombotic mutations; our study had the power to detect a 2.5-fold increased risk of thrombosis for any of these significant mutations. In addition, MTHFR667 heterozygosity was found in 41% of infants and MTHFR1298 heterozygosity in 52% and also were not associated with increased risk of UC-associated thrombus. The risk of MTHFR double heterozygosity (db het) was 14%, the risk of a significant or db het was 17/51 (33%) and the risk of any mutation was 90%.Conclusion: Prothrombotic genetic mutations are common in our Neonatal Intensive Care Unit population but do not appear to increase the risk of UC-associated thrombosis.

show abstract

“…Protein C deficiency was diagnosed in nine subjects. The author concluded that genetic risk factors for familial thrombophilia play an important role in the manifestation of catheter-related thromboembolism in children (24). Wermes evaluated the clinical relevance of genetic risk factors of thrombosis in 137 paediatric patients with malignancy.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Vein Thrombosis Post Cabg Precipitated by Malposition of Subclavian Central Catheter in Protein C & S Deficiency Patient

Sabzi

Faraji

2015

Ethiop J Health Sci

View full text Add to dashboard Cite

BACKGROUND: Cerebral venous thrombosis is an uncommon disorder in the general population. However, it has a higher frequency among patients younger than 40 years , patients with thrombophilia and patients that have foreign body such as catheter in their veins or arterial system. CASE DETAILS: In this case report, we described the clinical and radiological findings of a patient who developed cerebral vein thrombosis post coronary artery bypass grafting secondary undiagnosed protein C and S deficiency which was precipitated by malposition of subclavian central catheter into internal jugular vein. CONCLUSION: We emphasis the importance of radiological veiw of central vein catheter position just after or at the time of cannulation of central vein, not at some hours later as in our case.

show abstract

Factor V Leiden, protein C, and lipoprotein (a) in catheter-related thrombosis in childhood: A prospective study

Cited by 125 publications

References 36 publications

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Abdominal venous thrombosis in neonates and infants: role of prothrombotic risk factors – a multicentre case–control study

Genetic prothrombotic mutations are common in neonates but are not associated with umbilical catheter-associated thrombosis

Cerebral Vein Thrombosis Post Cabg Precipitated by Malposition of Subclavian Central Catheter in Protein C & S Deficiency Patient

Contact Info

Product

Resources

About