Facilitation of sexual behavior in male rats following d -amphetamine-induced behavioral sensitization

Fiorino, Dennis F.; Phillips, Anthony G.

doi:10.1007/s002130050880

Cited by 100 publications

(69 citation statements)

References 47 publications

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“…Indeed, preliminary observations from our laboratory indicate that rats sensitized by previous psychostimulant drug administration exhibit excessive cue-triggered reward-seeking behavior in this pure conditioned incentive paradigm (Wyvell and Berridge, 2000). These results are compatible with other evidence that sensitization increases the conditioned incentive value of reward-related stimuli (Harmer and Phillips, 1998;De Vries et al, 1999;Fiorino and Phillips, 1999;Taylor and Horger, 1999).…”

Section: Enhancement Of Incentive Salience Attributed To Cs؉supporting

confidence: 92%

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

2000

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Amphetamine microinjection into the nucleus accumbens shell enhanced the ability of a Pavlovian reward cue to trigger increased instrumental performance for sucrose reward in a pure conditioned incentive paradigm. Rats were first trained to press one of two levers to obtain sucrose pellets. They were separately conditioned to associate a Pavlovian cue (30 sec light) with free sucrose pellets. On test days, the rats received bilateral microinjection of intra-accumbens vehicle or amphetamine (0.0, 2.0, 10.0, or 20.0 g/0.5 l), and lever pressing was tested in the absence of any reinforcement contingency, while the Pavlovian cue alone was freely presented at intervals throughout the session. Amphetamine microinjection selectively potentiated the cue-elicited increase in sucrose-associated lever pressing, although instrumental responding was not reinforced by either sucrose or the cue during the test. Intra-accumbens amphetamine can therefore potentiate cue-triggered incentive motivation for reward in the absence of primary or secondary reinforcement. Using the taste reactivity measure of hedonic impact, it was shown that intra-accumbens amphetamine failed to increase positive hedonic reaction patterns elicited by sucrose (i.e., sucrose "liking") at doses that effectively increase sucrose "wanting." We conclude that nucleus accumbens dopamine specifically mediates the ability of reward cues to trigger "wanting" (incentive salience) for their associated rewards, independent of both hedonic impact and response reinforcement.

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Section: Enhancement Of Incentive Salience Attributed To Cs؉supporting

confidence: 92%

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

2000

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“…However, it is important to note that assessment of operant responding began one day after drug termination (when sensitization is not generally observed) and that the reduction in motivation was seen only during the first four days of amphetamine withdrawal. Other studies, using different conditioning procedures, have found evidence for crosssensitization between amphetamine and natural rewards such as food (Nocjar & Penksepp, 2002), salt (Clark & Bernstein, 2004), sucrose (Avena & Hoebel, 2003a, 2003bWyvell & Berridge, 2001) and sex (Fiorino & Phillips, 1999;Levens & Akins, 2004) 7-21 days after drug termination.…”

Section: Discussionmentioning

confidence: 98%

“…Indeed, evidence for cross sensitization between amphetamine and sex has been found in male rats (Fiorino & Phillips, 1999;Nocjar & Panksepp, 2002) and between cocaine and sex in male Japanese quail (Levens & Akins, 2004). In these studies, animals that exhibited behavioral sensitization to the drug exhibited more appetitive sexual behaviors than saline controls, despite the fact that they were in a drug free state at the time of testing.…”

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confidence: 99%

Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Klein

Gehrke

Green

et al. 2007

Learning and Motivation

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The purpose of the present experiment was to determine whether repeated cocaine exposure differentially affects sucrose-reinforced operant responding in rats raised in an enriched condition (EC) or an isolated condition (IC). Specifically, the performance of EC and IC rats pressing a lever for sucrose under a high fixed-ratio schedule (FR 30) prior to and after 10 days of exposure to cocaine (15 mg/kg, i.p.) or saline was compared. Regardless of rearing condition, rats repeatedly exposed to cocaine had shorter reacquisition latencies to complete a sucrose-reinforced FR 30 task than saline controls. The results suggest that cocaine exposure may have crosssensitized both EC and IC rats to the reinforcing effects of sucrose or sucrose-associated cues, thus facilitating reacquisition of operant responding.

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“…(Robinson and Becker, 1986;Stewart and Badiani, 1993)). Psychostimulant-induced behaviors, and associated biochemical changes, that may be related to bipolar disorder show sensitization in behavioral responses including hyperactivity (Post, 1980), stereotypy (Einat and Szechtman, 1995), increased hedonia (Papp et al, 1993), or increased sexual behavior (Fiorino and Phillips, 1999). However, oscillations have been shown only in very limited measures (e.g.…”

mentioning

confidence: 99%

Animal models of bipolar disorder and mood stabilizer efficacy: A critical need for improvement

Gould

Einat

2007

Neuroscience & Biobehavioral Reviews

108

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The limited number of suitable animal models of bipolar disorder available for in-depth behavioral, biochemical, histological, and pharmacological analysis is a rate limiting step in the process of understanding the relevant neurobiology of the disorder, as well as the development of novel medications. In the search for new models, both new and old approaches hold promise for future discoveries. Clinical studies regarding the underlying genetics and pathophysiology of bipolar disorder are providing important clues. In particular, the identification of susceptibility genes for bipolar disorder will help to define specific neurobiological processes, and associated behaviors, that are unquestionably involved in the pathways connecting genes and distal symptoms. These endophenotypes will hold great value in further enhancing the validity of animal models and will strongly complement symptom-based models and models of medication efficacy. Regardless of the path taken by different researchers to develop better models, we believe that this area of work requires additional attention not only from researchers but also from funding agencies.

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Facilitation of sexual behavior in male rats following d -amphetamine-induced behavioral sensitization

Cited by 100 publications

References 47 publications

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

Intra-Accumbens Amphetamine Increases the Conditioned Incentive Salience of Sucrose Reward: Enhancement of Reward “Wanting” without Enhanced “Liking” or Response Reinforcement

Repeated cocaine experience facilitates sucrose-reinforced operant responding in enriched and isolated rats

Animal models of bipolar disorder and mood stabilizer efficacy: A critical need for improvement

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