Facilitation of reflex swallowing from the pharynx and larynx

Kitagawa, Junichi; Nakagawa, Kazuharu; Hasegawa, Momoko; Iwakami, Tomoyo; Shingai, Tomio; Yamada, Yoshiaki; Iwata, Koichi

doi:10.2334/josnusd.51.167

Cited by 40 publications

(28 citation statements)

References 22 publications

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“…Specifically, water responses have been observed in the chorda tympani nerve (a branch of the facial nerve innervating taste buds on the rostral 2/3 of the tongue) of the rat, cat, and dog (Pfaffmann and Bare, 1950; Liljestrand and Zotterman, 1954; Zotterman, 1956), superior laryngeal nerve (a branch of the vagus nerve innervating taste buds on the palate) of the rat (Shinghai, 1980; Hanamori, 2001) and glossopharyngeal nerve (innervating taste buds on the caudal 1/3 of the tongue) of the frog, hamster, and rat (Zotterman, 1949; Hanamori et al, 1988; Frank, 1991). Water specialist fibers have been observed in the superior laryngeal nerve (Shinghai, 1980), a nerve that plays an important role in swallowing (Kitagawa et al, 2009). Interestingly, water applied to the posterior tongue/larynx in humans was shown to be particularly effective at evoking a swallowing reflex as compared to other taste stimuli (Shinghai et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Water as an Independent Taste Modality

Rosen¹,

Roussin²,

Lorenzo³

2010

Front. Neurosci.

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To qualify as a “basic” taste quality or modality, defined as a group of chemicals that taste alike, three empirical benchmarks have commonly been used. The first is that a candidate group of tastants must have a dedicated transduction mechanism in the peripheral nervous system. The second is that the tastants evoke physiological responses in dedicated afferent taste nerves innervating the oropharyngeal cavity. Last, the taste stimuli evoke activity in central gustatory neurons, some of which may respond only to that group of tastants. Here we argue that water may also be an independent taste modality. This argument is based on the identification of a water dedicated transduction mechanism in the peripheral nervous system, water responsive fibers of the peripheral taste nerves and the observation of water responsive neurons in all gustatory regions within the central nervous system. We have described electrophysiological responses from single neurons in nucleus of the solitary tract (NTS) and parabrachial nucleus of the pons, respectively the first two central relay nuclei in the rodent brainstem, to water presented as a taste stimulus in anesthetized rats. Responses to water were in some cases as robust as responses to other taste qualities and sometimes occurred in the absence of responses to other tastants. Both excitatory and inhibitory responses were observed. Also, the temporal features of the water response resembled those of other taste responses. We argue that water may constitute an independent taste modality that is processed by dedicated neural channels at all levels of the gustatory neuraxis. Water-dedicated neurons in the brainstem may constitute key elements in the regulatory system for fluid in the body, i.e., thirst, and as part of the swallowing reflex circuitry.

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Section: Discussionmentioning

confidence: 99%

Water as an Independent Taste Modality

Rosen¹,

Roussin²,

Lorenzo³

2010

Front. Neurosci.

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“…Stimulation of glossopharyngeal afferents can also induce fictive swallowing both in animals and humans (Chi-Fishman, Capra and Mccall, 1994; Fujiu, Toleikis, Logemann, et al, 1994; Kitagawa, Shingai, Takahashi, et al, 2002; Kitagawa, Nakagawa, Hasegawa, et al, 2009). Normally swallowing occurs spontaneously every few minutes and controls salivary flow.…”

Section: Swallowing Cns Controlmentioning

confidence: 99%

Central Nervous System Control of Voice and Swallowing

Ludlow

2015

Journal of Clinical Neurophysiology

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This review of the central nervous control systems for voice and swallowing has suggested that the traditional concepts of a separation between cortical and limbic and brain stem control should be refined and more integrative. For voice production, a separation of the non-human vocalization system from the human learned voice production system has been posited based primarily on studies of non-human primates. However, recent humans studies of emotionally based vocalizations and human volitional voice production has shown more integration between these two systems than previously proposed. Recent human studies have shown that reflexive vocalization as well as learned voice production not involving speech, involve a common integrative system. On the other hand, recent studies of non-human primates have provided evidence of some cortical activity during vocalization and cortical changes with training during vocal behavior. For swallowing, evidence from the macaque and functional brain imaging in humans indicates that the control for the pharyngeal phase of swallowing is not primarily under brain stem mechanisms as previously proposed. Studies suggest that the initiation and patterning of swallowing for the pharyngeal phase is also under active cortical control for both spontaneous as well as volitional swallowing in awake humans and non-human primates.

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“…The lingual branch is minimally involved with the elicitation of cough and swallowing, but serves to innervate the posterior tongue, tonsils, vallate papillae, and epiglottis 78 . The pharyngeal branch of CN IX is directly involved in the initiation of cough and swallowing 56 . This branch of CN IX further subdivides into superior, middle, and inferior branches providing sensory innervation to the oropharynx, lateral pharyngeal wall, and pharyngeal plexus (including the UES and inferior pharyngeal constrictor) 78 .…”

Section: Afferentsmentioning

confidence: 99%

A framework for understanding shared substrates of airway protection

et al. 2014

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Deficits of airway protection can have deleterious effects to health and quality of life. Effective airway protection requires a continuum of behaviors including swallowing and cough. Swallowing prevents material from entering the airway and coughing ejects endogenous material from the airway. There is significant overlap between the control mechanisms for swallowing and cough. In this review we will present the existing literature to support a novel framework for understanding shared substrates of airway protection. This framework was originally adapted from Eccles' model of cough28 (2009) by Hegland, et al.42 (2012). It will serve to provide a basis from which to develop future studies and test specific hypotheses that advance our field and ultimately improve outcomes for people with airway protective deficits.

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Facilitation of reflex swallowing from the pharynx and larynx

Cited by 40 publications

References 22 publications

Water as an Independent Taste Modality

Water as an Independent Taste Modality

Central Nervous System Control of Voice and Swallowing

A framework for understanding shared substrates of airway protection

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