2023
DOI: 10.1001/jamanetworkopen.2023.23500
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Facilitation of Definitive Cancer Diagnosis With Quantitative Molecular Assays of BRAF V600E and TERT Promoter Variants in Patients With Thyroid Nodules

Guodong Fu,
Ronald S. Chazen,
Eric Monteiro
et al.

Abstract: ImportanceMolecular testing of the presence of pathogenic genomic variants in a tumor without quantifying the variant allele fraction (VAF) does not differentiate the variation extent among tumors, often resulting in an inconclusive diagnosis because of interpatient variability.ObjectiveTo examine the association between the quantification of VAFs of BRAF V600E and TERT promoter variants and a definitive cancer diagnosis of thyroid tumors.Design, Setting, and ParticipantsThis diagnostic study analyzed a cohort… Show more

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