Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms

Culebras, Mario; Pishnamazi, Mahboubeh; Walker, Gavin; Collins, Maurice N.

doi:10.3390/molecules26061593

Cited by 116 publications

(17 citation statements)

References 38 publications

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“…For the system from which a compound is released through the membrane has a single target component, both the membrane transport experiments and their modeling have been extensively and thoroughly studied [46][47][48][49][50]. For systems that simultaneously release two or more target chemical species, both experiments, but especially process modeling, become much more complex [51][52][53].…”

Section: Resultsmentioning

confidence: 99%

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

et al. 2022

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The bio-medical benefits of silver ions and 10–undecenoic acid in various chemical-pharmaceutical preparations are indisputable, thus justifying numerous research studies on delayed and/or controlled release. This paper presents the effect of the polymer matrix in the simultaneous release of silver ions and 10–undecenoic acid in an aqueous medium of controlled pH and ionic strength. The study took into consideration polymeric matrices consisting of cellulose acetate (CA) and polysulfone (PSf), which were impregnated with oxide nanoparticles containing silver and 10–undecenoic acid. The studied oxide nanoparticles are nanoparticles of iron and silver oxides obtained by an accessible electrochemical method. The obtained results show that silver can be released, simultaneously with 10–undecenoic acid, from an impregnated polymeric membrane, at concentrations that ensure the biocidal and fungicidal capacity. Concentrations of active substances can be controlled by choosing the polymer matrix or, in some cases, by changing the pH of the target medium. In the studied case, higher concentrations of silver ions are released from the polysulfone matrix, while higher concentrations of 10–undecenoic acid are released from the cellulose acetate matrix. The results of the study show that a correlation can be established between the two released target substances, which is dependent on the solubility of the organic compound in the aqueous medium and the interaction of this compound with the silver ions. The ability of 10–undecenoic acid to interact with the silver ion, both through the carboxyl and alkene groups, contributes to the increase in the content of the silver ions transported in the aqueous medium.

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Section: Resultsmentioning

confidence: 99%

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

et al. 2022

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“…In this regard, hydrogels produced with a lignin:PEGDGE 1:1 ratio displayed up to 30% of paracetamol release after 120 h assay. The release data follow a pseudo-Fickian behavior of diffusion when fitted to the Korsmeyer-Peppas model [50]. Furthermore, lignin polymers have been mixed with cellulose to generate drug delivery systems.…”

Section: Other Chemically Cross-linked Biopolymersmentioning

confidence: 99%

Sustained Drug Release from Biopolymer-Based Hydrogels and Hydrogel Coatings

Olmo¹,

Martínez²,

González³

et al. 2023

Hydrogels - From Tradition to Innovative Platforms With Multiple Applications

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Biopolymer based hydrogels are three-dimensional physically or chemically crosslinked polymeric networks based on natural polymers, with an intrinsic hydrophilic character due to their functional groups. They display high water content, softness, flexibility, permeability, and biocompatibility and possess a very high affinity for biological fluids. These properties resemble those of many soft living tissues, which opens up many opportunities in the biomedical field. In this regard, hydrogels provide fine systems for drug delivery and sustained release of drugs. Moreover, biopolymer based hydrogels can be applied as coatings on medical implants in order to enhance the biocompatibility of the implants and to prevent medical conditions. In this chapter we review the latest achievements concerning the use of biopolymeric physical and chemically crosslinked hydrogels as well as hydrogel coatings as sustained drug release platforms.

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“…The resulting lignin is characterized by a low molecular weight, high chemical purity, solubility in alkaline systems, and polar solvents [33]. The group of non-sulfur lignin also includes explosive lignin, characterized by a low molecular weight and solubility in organic solvents [34,35]. In addition to the lignin groups mentioned above, there are also ground lignin, pyrolytic lignin, and hydrolytic lignin.…”

Section: Utilization Of Lignin Wastementioning

confidence: 99%

The Reuse of Biomass and Industrial Waste in Biocomposite Construction Materials for Decreasing Natural Resource Use and Mitigating the Environmental Impact of the Construction Industry: A Review

Ryłko-Polak

Komala²,

Białowiec

2022

Materials

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The construction industry is the world’s largest emitter of greenhouse gases. The CO2 emission levels in the atmosphere are already reaching a tipping point and could cause severe climate change. An important element is the introduction of a technology that allows for the capture and sequencing of carbon dioxide levels, reducing both emissions and the carbon footprint from the production of Portland cement and cement-based building materials. The European Union has started work on the European Climate Law, establishing the European Green Deal program, which introduces the achievement of climate neutrality in the European Union countries. This includes a new policy of sustainable construction, the aim of which is to develop products with a closed life cycle through proper waste management. All efforts are being made to create generated waste and thus to support their production and/or use as substitutes for raw materials to produce biocomposites. This article reviews environmental issues and characterizes selected waste materials from the agri-food, mineral, and industrial sectors with specific properties that can be used as valuable secondary raw materials to produce traditional cements and biocomposite materials, while maintaining or improving their mechanical properties and applications.

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Facile Tailoring of Structures for Controlled Release of Paracetamol from Sustainable Lignin Derived Platforms

Cited by 116 publications

References 38 publications

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

Simultaneous Release of Silver Ions and 10–Undecenoic Acid from Silver Iron–Oxide Nanoparticles Impregnated Membranes

Sustained Drug Release from Biopolymer-Based Hydrogels and Hydrogel Coatings

The Reuse of Biomass and Industrial Waste in Biocomposite Construction Materials for Decreasing Natural Resource Use and Mitigating the Environmental Impact of the Construction Industry: A Review

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