Sustained Drug Release from Biopolymer-Based Hydrogels and Hydrogel Coatings

Olmo, Jon Andrade del; Martínez, Virginia Sáez; González, Raúl Pérez; Alonso, José María Rabal

doi:10.5772/intechopen.103946

Cited by 3 publications

(1 citation statement)

References 80 publications

(82 reference statements)

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“…Sustained drug delivery is a powerful approach with which to endow hydrogels with advantageous antibacterial and anti-inflammatory activities and, thus, combat adverse effects after injection into the human body [46,47]. Accordingly, CFX, TCN, and AMX antibiotics and the ASA anti-inflammatory agent were separately loaded and released in physiological conditions (PBS, 37 • C) from different hydrogel formulations (Figure 5) in order to analyze the effect of reaction time (HA-BDDE-1 vs. HA-BDDE-4) and BDDE quantity (HA-BDDE-4 vs. HA-BDDE-6) on their drug delivery properties.…”

Section: Drug Loading and Release Studiesmentioning

confidence: 99%

Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications

Olmo

Pérez‐Álvarez

Martínez

et al. 2022

Gels

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Hyaluronic acid (HA) injectable biomaterials are currently applied in numerous biomedical areas, beyond their use as dermal fillers. However, bacterial infections and painful inflammations are associated with healthcare complications that can appear after injection, restricting their applicability. Fortunately, HA injectable hydrogels can also serve as drug delivery platforms for the controlled release of bioactive agents with a critical role in the control of certain diseases. Accordingly, herein, HA hydrogels were crosslinked with 1 4-butanediol diglycidyl ether (BDDE) loaded with cefuroxime (CFX), tetracycline (TCN), and amoxicillin (AMX) antibiotics and acetylsalicylic acid (ASA) anti-inflammatory agent in order to promote antibacterial and anti-inflammatory responses. The hydrogels were thoroughly characterized and a clear correlation between the crosslinking grade and the hydrogels’ physicochemical properties was found after rheology, scanning electron microscopy (SEM), thermogravimetry (TGA), and differential scanning calorimetry (DSC) analyses. The biological safety of the hydrogels, expected due to the lack of BDDE residues observed in 1H-NMR spectroscopy, was also corroborated by an exhaustive biocompatibility test. As expected, the in vitro antibacterial and anti-inflammatory activity of the drug-loaded HA-BDDE hydrogels was confirmed against Staphylococcus aureus by significantly decreasing the pro-inflammatory cytokine levels.

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Section: Drug Loading and Release Studiesmentioning

confidence: 99%

Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications

Olmo

Pérez‐Álvarez

Martínez

et al. 2022

Gels

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Biopolymer Composites Material Extrusion and their Applications: A Review

Li,

Yang,

Elias

et al. 2023

Adv Eng Mater

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Advances in additive manufacturing are leading to the emergence of new printable applications, including sensors for healthcare monitoring and bioengineering scaffolds. Research is driven by designing new printable inks including composites that can be extruded and respond to changes in their surroundings and patterning these materials on the microscale. In modern printing techniques, an emerging modified three‐dimensional (3D) printing method: materials extrusion has been utilized for customizable electronics because of its high compatibility with various inks, low cost, and versatility to different levels of complexity. Material extrusion enables not only the printing of 2D and 3D architecture of the electrode structure but also the bioprinting of structures such as conductive scaffolds. In this review, fundamental insights into rational printable ink formulation including colloidal suspensions, gels, polymer melts, composites, printing criteria, processes, and applications toward printable electronics using composites composed of nanomaterials and biopolymers are fully discussed. New manufacturing insights on how to further improve the resolution and simplify the printing process of responsive materials are discussed, which have not been seen in currently published representative reviews. It is envisioned that this review provides high scientific merits to readers working in wearable devices, biological smart materials, and flexible nanoelectronics.

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A Critical Sojourn of Hyaluronic Acid-based Hydrogels in the Wound Healing Process: Current Advances and Future Prospects

Markandeywar,

Singh,

Narang

2024

CDTH

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"Hyaluronic acid (HA), a non-sulfated glycosaminoglycan (GAG), is a significant component of the epidermal extracellular matrix (ECM). It plays multiple roles in the inflammatory response, cell adhesion, migration, proliferation, differentiation, angiogenesis, and tissue regeneration. Due to its inherent characteristics, including non-immunoreactivity, exceptional biocompatibility, biodegradability, native biofunctionality, hydrophilicity, and non-immunoreactivity, HA has found applications in the production of wound dressings. HA's synergistic role in enhancing deeper penetration into chronic wounds and its biofunctional properties in the healing process have been harnessed. HA-based wound dressings, often incorporating biomolecules or drugs to improve the dressing's biochemical performance during wound healing, have been developed. In this review, we explore the current state of knowledge regarding hydrogels based on HA, focusing on their biofunctional properties and delivery mechanisms. We present the latest developments in the research and development of HA-based hydrogels for the treatment of skin wounds."

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Sustained Drug Release from Biopolymer-Based Hydrogels and Hydrogel Coatings

Cited by 3 publications

References 80 publications

Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications

Drug Delivery from Hyaluronic Acid–BDDE Injectable Hydrogels for Antibacterial and Anti-Inflammatory Applications

Biopolymer Composites Material Extrusion and their Applications: A Review

A Critical Sojourn of Hyaluronic Acid-based Hydrogels in the Wound Healing Process: Current Advances and Future Prospects

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