Facile synthesis, spectral characterization, antimicrobial and in vitro cytotoxicity of novel N3,N5-diisonicotinyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarbohydrazide derivatives

Elumalai, Karthikeyan; Elumalai, Manogaran; Eluri, Kalpana; Srinivasan, S.; Ali, Mohamed Ashraf; Reddy, Basu Venkateswara; Sarangi, Sarada Prasad

doi:10.1016/j.bfopcu.2016.01.003

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…Nitrogen-containing compounds are found in a wide range of natural products, and biologically active molecules, [1] and have numerous applications in the fields ranging from material science to agrochemicals. Dihydropyridines stand out due to their wide range of biological activities, which include antihypertensive, [2][3] antitumor, [4][5] antitubercular, [6] antimicrobial, [7] antioxidant, [8][9] and so on. Dihydropyridines are a large medicinally significant class of drugs in pharmaceuticals.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Merugu

Ansari

et al. 2023

Chemistry & Biodiversity

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An efficient 1,4‐dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4‐dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT‐29, and HepG2 cancer cells were used to investigate the anticancer efficacy of each of the produced compounds. Additionally, in‐silico docking studies were conducted to understand the structure‐based features of the anticancer mechanism with the cancer medication target of Adenosine A2A receptor as well as the molecular level interactions of the compounds.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Merugu

Ansari

et al. 2023

Chemistry & Biodiversity

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“… 5,6 Among various heterocyclic ring systems, 1,4-dihydropyridine (1,4-DHP) and its derivatives serve as important heterocyclic scaffolds that have gained special attention among synthetic chemists due to their special features, such as distinctive molecular structure, low molecular mass, and widespread pharmaceutical activities. The 1,4-dihydropyridine core is extensively utilized in several biological and therapeutic applications such as anti-tumor, 7 calcium blocker agents in heart disease, antianginal, 8 antihypertensive, 9 antidiabetic, 10 and antimicrobial 11 agents. The importance of the 1,4-DHP nuclei is evident from the fact that it is prevalent in several commercial drugs such as Felodipine, Diludine, Amlodipine, Oxodipine, and Nifedipine, as shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Recent developments in the nanomaterial-catalyzed green synthesis of structurally diverse 1,4-dihydropyridines

Mathur¹,

Negi

Shrivastava

et al. 2021

RSC Adv.

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“…Aiming to attain the prominent performance of PSO, the adaptive strategy was introduced to dynamically update the parameters of the algorithm in prior studies, i.e., inertia weight [17][18][19][20][21], velocity and position [22,23], and ω, c 1 , and c 2 of each particle [5,24]. Wang et al [25] and Li and Cheng et al [26] introduced a mixed adaptive strategy to adjust the parameters in order to balance the search and convergence capabilities.…”

Section: Introductionmentioning

confidence: 99%

Adaptive Particle Swarm Optimization with Gaussian Perturbation and Mutation

Chen

Zhang

Chen

et al. 2021

Scientific Programming

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The particle swarm optimization (PSO) is a wide used optimization algorithm, which yet suffers from trapping in local optimum and the premature convergence. Many studies have proposed the improvements to address the drawbacks above. Most of them have implemented a single strategy for one problem or a fixed neighborhood structure during the whole search process. To further improve the PSO performance, we introduced a simple but effective method, named adaptive particle swarm optimization with Gaussian perturbation and mutation (AGMPSO), consisting of three strategies. Gaussian perturbation and mutation are incorporated to promote the exploration and exploitation capability, while the adaptive strategy is introduced to ensure dynamic implement of the former two strategies, which guarantee the balance of the searching ability and accuracy. Comparison experiments of proposed AGMPSO and existing PSO variants in solving 29 benchmark functions of CEC 2017 test suites suggest that, despite the simplicity in architecture, the proposed AGMPSO obtains a high convergence accuracy and significant robustness which are proven by conducted Wilcoxon’s rank sum test.

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Facile synthesis, spectral characterization, antimicrobial and in vitro cytotoxicity of novel N3,N5-diisonicotinyl-2,6-dimethyl-4-phenyl-1,4-dihydropyridine-3,5-dicarbohydrazide derivatives

Cited by 5 publications

References 28 publications

Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Recent developments in the nanomaterial-catalyzed green synthesis of structurally diverse 1,4-dihydropyridines

Adaptive Particle Swarm Optimization with Gaussian Perturbation and Mutation

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