Synthesis, Anticancer Evaluation and in Silico Studies of 1,4‐Dihydropyridines

Abstract

An efficient 1,4‐dihydropyridine synthesis under mild conditions has been developed. Numerous substrates were tested, with yields of 1,4‐dihydropridines ranging from good to excellent and a wide range of functional group tolerance. A549, HT‐29, and HepG2 cancer cells were used to investigate the anticancer efficacy of each of the produced compounds. Additionally, in‐silico docking studies were conducted to understand the structure‐based features of the anticancer mechanism with the cancer medication target of Adenosine A2A receptor as well as the molecular level interactions of the compounds.