Facile synthesis of water-soluble, highly fluorescent graphene quantum dots as a robust biological label for stem cells

Zhang, Mo; Bai, Linling; Shang, Weihu; Xie, Wenjing; Ma, Hong; Fu, Yingyi; Fang, De‐Cai; Sun, Hui; Fan, Louzhen; Han, Mei; Liu, Chenmin; Yang, Shihe

doi:10.1039/c2jm16835a

Cited by 681 publications

(467 citation statements)

References 57 publications

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“…37 We found that after 1 h of synthesis, the I D/ I G ratio was 0.80 6 0.03, indicating that there are some defects in the C-dots' sp 2 -carbon lattice arising from oxidation and hetero-groups on the surface. 38 Such a ratio for the D-band to G-band is in the range that has been reported for high-quality CNPs. 9,13 Over time, as oxidation continues and the sp 2 -carbon lattice is defected further, the I D/ I G ratio of the CNPs increases significantly (p , 0.05) to 0.94 6 0.02 after one day of reaction, with a further increase (p , 0.05) to 1.01 6 0.04 after seven days of reaction.…”

Section: Resultsmentioning

confidence: 68%

Spectroscopic Characteristics of Carbon Dots (C-Dots) Derived from Carbon Fibers and Conversion to Sulfur-Bridged C-Dots Nanosheets

et al. 2015

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We synthesized sub-10 nm carbon nanoparticles (CNPs) consistent with photoluminescent carbon dots (C-dots) from carbon fiber starting material. The production of different C-dots fractions was monitored over seven days. During the course of the reaction, one fraction of C-dots species with relatively high photoluminescence was short-lived, emerging during the first hour of reaction but disappearing after one day of reaction. Isolation of this species during the first hour of the reaction was crucial to obtaining higherluminescent C-dots species. When the reaction proceeded for one week, the appearance of larger nanostructures was observed over time, with lateral dimensions approaching 200 nm. The experimental evidence suggests that these larger species are formed from small C-dot nanoparticles bridged together by sulfur-based moieties between the C-dot edge groups, as if the C-dots polymerized by cross-linking the edge groups through sulfur bridges. Their size can be tailored by controlling the reaction time. Our results highlight the variety of CNP products, from sub-10 nm C-dots to $200 nm sulfur-containing carbon nanostructures, that can be produced over time during the oxidation reaction of the graphenic starting material. Our work provides a clear understanding of when to stop the oxidation reaction during the top-down production of Cdots to obtain highly photoluminescent species or a target average particle size.

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Section: Resultsmentioning

confidence: 68%

Spectroscopic Characteristics of Carbon Dots (C-Dots) Derived from Carbon Fibers and Conversion to Sulfur-Bridged C-Dots Nanosheets

et al. 2015

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“…In particular, innovative carbon-based nanomaterials such as graphene quantum dots (GQDs) and graphene oxide quantum dots (GOQDs) have attracted much interest as stable, nontoxic, photoluminescent nanomaterials with possible applications in chemical and biological sensors, drug delivery, bio-imaging and energy conversion [7][8][9][10][11][12][13]. The physical origin of the photoluminescence (PL) from these carbonbased nanoparticles is still quite controversial and different mechanisms have been suggested, possibly acting together, mainly based on quantum confinement in sp 2 domains with a strong influence from edge and oxygen-containing functional groups [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Sensitivity to Heavy-Metal Ions of Unfolded Fullerene Quantum Dots

Ciotta¹,

Paoloni²,

Prosposito³

et al. 2017

Preprint

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A novel type of graphene-like quantum dots, synthesized by oxidation and cage-opening of C60 buckminsterfullerene, has been studied as a fluorescent and absorptive probe for heavy-metal ions.The lattice structure of such unfolded fullerene quantum dots (UFQDs) is distinct from that of graphene since it includes both carbon hexagons and pentagons. The basic optical properties, however, are similar to those of regular graphene oxide quantum dots. On the other hand, UFQDs behave quite differently in the presence of heavy-metal ions, in that multiple sensitivity to Cu 2+ , Pb 2+ and As(III) was observed through comparable quenching of the fluorescent emission and different variations of the transmittance spectrum. By dynamic light scattering measurements we confirmed, for the first time in metal sensing, that this response is due to multiple complexation and subsequent aggregation of UFQDs. Nonetheless, the explanation of the distinct behaviour of transmittance in the presence of As(III) and the formation of precipitate with Pb 2+ require further studies. These differences, however, also make it possible to discriminate between the three metal ions in view of the implementation of a selective multiple sensor.

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“…石墨烯的边缘修饰有大量的酰肼基团和类似于邻苯二甲酰肼的基团, 使得石墨烯可以发出强烈的黄色荧光. 由于这种结构以石墨烯为结构基础, 其荧光稳定性及荧光强度均比相似结构的酰肼类的荧光染料有所增强 [20,21] . …”

Section: 引言unclassified

Preparation of Fluorescent Graphene Quantum Dots as Biological Imaging Marker for Cells

Xie¹,

Fu²,

Ma³

et al. 2012

Acta Chim. Sinica

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Facile synthesis of water-soluble, highly fluorescent graphene quantum dots as a robust biological label for stem cells

Cited by 681 publications

References 57 publications

Spectroscopic Characteristics of Carbon Dots (C-Dots) Derived from Carbon Fibers and Conversion to Sulfur-Bridged C-Dots Nanosheets

Spectroscopic Characteristics of Carbon Dots (C-Dots) Derived from Carbon Fibers and Conversion to Sulfur-Bridged C-Dots Nanosheets

Sensitivity to Heavy-Metal Ions of Unfolded Fullerene Quantum Dots

Preparation of Fluorescent Graphene Quantum Dots as Biological Imaging Marker for Cells

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