Facile Synthesis of Triazoles using Electrospray‐Deposited Copper Nanomaterials to Catalyze Azide‐Alkyne Cycloaddition (AAC) Click Reactions

Abstract

Electrospray deposition of copper salt‐containing microdroplets onto the liquid surface of an electrically grounded reaction mixture leads to the formation of Cu nanoclusters, which then catalyze the azide‐alkyne cycloaddition (AAC) reaction to form triazoles. This method of in situ nanocatalyst preparation provided 17 times higher catalytic activity compared to that in the conventional catalytic reaction. The gentle landing of the Cu‐containing droplets onto the liquid surface forms a thin film of catalyst which promotes the heterogeneous AAC reaction while showing diffusion‐controlled kinetics. UV‐vis spectral characterization confirms that the catalyst is comprised of Cu nanoclusters. This unique catalytic strategy was validated using several substrates and the corresponding products were confirmed by tandem mass spectrometry (MS/MS) analysis.

Azide-Assisted Growth of Copper Nanostructures and Their Application as a Carbon Supported Catalyst in Two-Step Three-Component Azide–Alkyne Cycloadditions

“…And lastly, the MSAs themselves tend to arrange in even larger assemblies of multiple MSAs with many arranged linearly. In contrast, many other methods involving Cu NPs produced fine NPs, which impregnate the carbon support. ,,, In some reports, the support was oxidatively pretreated , or subject to pyrolytic processing after Cu deposition . However, these treatments do not appear to be generally crucial for the formation of small NPs.…”

Re‐Imagining Drug Discovery using Mass Spectrometry

“…It is worth noting that the use of mass spectrometry in synthesis is not confined to droplet chemistry. Ions are being used as chemical reagents to modify surfaces, prepare catalysts, [75][76][77] and create devices involving a variety of types of fundamental processes that include reactive scattering and ion soft landing. [78,79] Earlier examples of ion beam chemical synthesis were associated with ion/surface chemistry.…”