An expedient heterogeneous catalyst for one-pot tandem synthesis of 1-aryl-1, 2, 3-triazoles through Huisgen 1,3-cycloaddition

Recent advances in Chan–Lam coupling reaction

“…Pharande's research group recently unveiled a pioneering cellulose-based heterogeneous copper catalytic system for the synthesis of 1-aryl-1,2,3-triazoles. 63 This greener one-pot multicomponent synthesis of 1-aryl-1,2,3-triazoles involves consecutive Chan–Lam coupling and Huisgen 1,3-cycloaddition. The sodium azide, phenylboronic acids, and phenyl acetylenes were reacted in the presence of 0.072 mol% of a cellulose-based copper catalyst (Cell-ThP-Cu( ii )) in water at room temperature for 6 h (Scheme 60).…”