Facile synthesis of three-dimensional porous hydrogel and its evaluation

Danish, Zeeshan; Ijaz, Hira; Razzaque, Ghulam; Haq, Nazrul; Aslam, Muhammad Mahran

doi:10.1007/s00289-021-03855-y

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…The effective property of SPHHs-AT is its rapid swelling ability [ 39 , 40 ]. The swelling ratio of SPHHs-AT preparations in an HCl buffer solution of pH 1.2 is represented in Figure 2 a.…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Juthi

Wang

et al. 2023

Pharmaceutics

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Super-porous hydrogels are considered a potential drug delivery network for the sedation of gastric mechanisms with retention windows in the abdomen and upper part of the gastrointestinal tract (GIT). In this study, a novel pH-responsive super-porous hybrid hydrogels (SPHHs) was synthesized from pectin, poly 2-hydroxyethyl methacrylate (2HEMA), and N, N methylene-bis-acrylamide (BIS) via the gas-blowing technique, and then loaded with a selected drug (amoxicillin trihydrate, AT) at pH 5 via an aqueous loading method. The drug-loaded SPHHs-AT carrier demonstrated outstanding (in vitro) gastroretentive drug delivery capability. The study attributed excellent swelling and delayed drug release to acidic conditions at pH 1.2. Moreover, in vitro controlled-release drug delivery systems at different pH values, namely, 1.2 (97.99%) and 7.4 (88%), were studied. These exceptional features of SPHHs—improved elasticity, pH responsivity, and high swelling performance—should be investigated for broader drug delivery applications in the future.

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“…The effective property of SPHHs-AT is its rapid swelling ability [ 39 , 40 ]. The swelling ratio of SPHHs-AT preparations in an HCl buffer solution of pH 1.2 is represented in Figure 2 a.…”

Section: Resultsmentioning

confidence: 99%

pH-Responsive Super-Porous Hybrid Hydrogels for Gastroretentive Controlled-Release Drug Delivery

Juthi

Wang

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…These nexuses are three-dimensional architectures that can imbibe a remarkable amount of water while retaining their mechanical attributes. These nexuses are known as intelligent material/ smart materials as these nexuses respond to external stimuli like ionic strength, pH and temperature which in turn promote phase transition, augmented volume and pore size of the matrix ( Danish et al, 2021 ). Hydrophilic pendent moieties (-SO 3 H, –OH, CONH 2 and –CONH) aid in retaining media thereby improving swelling which results in the formation of elastic, soft architecture whose biological, chemical and physical properties can be manipulated as per desired response.…”

Section: Introductionmentioning

confidence: 99%

“…Pectin is a complex polysaccharide comprising of galacturonic acid units which are joined together through 1, 4-ɑ-glucoside bonds ( Padmasri et al, 2020 , Danish et al, 2021 , Azam et al, 2021 ). The literature survey supports the fact that Pectin has controlled release attributes as well as gelation capability which is attributed to the degree of esterification.…”

Section: Introductionmentioning

confidence: 99%