Facile synthesis of pyrazolopyridine pharmaceuticals under mild conditions using an algin-functionalized silica-based magnetic nanocatalyst (Alg@SBA-15/Fe<sub>3</sub>O<sub>4</sub>)

Hassanzadeh‐Afruzi, Fereshte; Amiri-Khamakani, Zeinab; Salehi, Mohammad; Taheri‐Ledari, Reza; Maleki, Ali

doi:10.1039/d2ra07228a

Cited by 10 publications

(3 citation statements)

References 58 publications

(73 reference statements)

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“…7,8 Nowadays, the compilation of Watson–Crick pairing methods and nucleotide synthesis strategies has opened new windows for researchers in the field of materials science. 9,10 Generally, hydrogels are considered as a highly appropriate substrate in various areas such as energy, 11–13 catalysis, 14–19 environmental sciences, 20–26 and medical applications. 27–31 Specifically, in the area of drug delivery to cancer tissues, hydrogels are widely used because they are capable of absorbing water molecules and swelling in the target organ, resulting in drug release in a controlled manner.…”

Section: Introductionmentioning

confidence: 99%

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Zare¹,

Taheri‐Ledari²,

Esmailzadeh³

et al. 2023

Nanoscale

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Section: Introductionmentioning

confidence: 99%

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Zare¹,

Taheri‐Ledari²,

Esmailzadeh³

et al. 2023

Nanoscale

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“…As preventing adsorbent loss during its isolation from the reaction mixture matters, preparing magnetic nanocomposites or applying natural substances with innate magnetic feature has been noticed 42 . In this regard, magnetic nanoparticles (MNPs) integration in the nanocomposites barricade the nanocomposite loss during adsorption–desorption cycles and improves the scale-up efficiency in water refinement and adsorption of contaminants 43 , 44 . The incorporation of clay-based materials, i.e., bentonite in the adsorbent system has lighten the way of adsorption capacity improvement whether in single-phase or as a composites’ component 45 .…”

Section: Introductionmentioning

confidence: 99%

Enhancement of adsorption efficiency of crystal violet and chlorpyrifos onto pectin hydrogel@Fe3O4-bentonite as a versatile nanoadsorbent

Beigi

Ganjali

Hassanzadeh‐Afruzi

et al. 2023

Sci Rep

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The magnetic mesoporous hydrogel-based nanoadsornet was prepared by adding the ex situ prepared Fe3O4 magnetic nanoparticles (MNPs) and bentonite clay into the three-dimentional (3D) cross-linked pectin hydrogel substrate for the adsorption of organophosphorus chlorpyrifos (CPF) pesticide and crystal violet (CV) organic dye. Different analytical methods were utilized to confirm the structural features. Based on the obtained data, the zeta potential of the nanoadsorbent in deionized water with a pH of 7 was − 34.1 mV, and the surface area was measured to be 68.90 m2/g. The prepared hydrogel nanoadsorbent novelty owes to possessing a reactive functional group containing a heteroatom, a porous and cross-linked structure that aids convenient contaminants molecules diffusion and interactions between the nanoadsorbent and contaminants, viz., CPF and CV. The main driving forces in the adsorption by the Pectin hydrogel@Fe3O4-bentonite adsorbent are electrostatic and hydrogen-bond interactions, which resulted in a great adsorption capacity. To determine optimum adsorption conditions, effective factors on the adsorption capacity of the CV and CPF, including solution pH, adsorbent dosage, contact time, and initial concentration of pollutants, have been experimentally investigated. Thus, in optimum conditions, i.e., contact time (20 and 15 min), pH 7 and 8, adsorbent dosage (0.005 g), initial concentration (50 mg/L), T (298 K) for CPF and CV, respectively, the CPF and CV adsorption capacity were 833.333 mg/g and 909.091 mg/g. The prepared pectin hydrogel@Fe3O4-bentonite magnetic nanoadsorbent presented high porosity, enhanced surface area, and numerous reactive sites and was prepared using inexpensive and available materials. Moreover, the Freundlich isotherm has described the adsorption procedure, and the pseudo-second-order model explained the adsorption kinetics. The prepared novel nanoadsorbent was magnetically isolated and reused for three successive adsorption–desorption runs without a specific reduction in the adsorption efficiency. Therefore, the pectin hydrogel@Fe3O4-bentonite magnetic nanoadsorbent is a promising adsorption system for eliminating organophosphorus pesticides and organic dyes due to its remarkable adsorption capacity amounts.

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“…The N-containing heterocyclic structures have been considered essential members of organic materials. They are the main scaffold of a wide spectrum of medicine and biologically active products 1 – 3 . These compounds have been attracted great attention for several decades because of their extensive applications in numerous fields, including medicine, veterinary products, disinfectants, and antioxidants 4 – 7 .…”

Section: Introductionmentioning

confidence: 99%

Utilizing magnetic xanthan gum nanocatalyst for the synthesis of acridindion derivatives via functionalized macrocycle Thiacalix[4]arene

Hassanzadeh-Afruzi,

Salehi,

Ranjbar

et al. 2023

Sci Rep

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An effective method for synthesizing acridinedione derivatives using a xanthan gum (XG), Thiacalix[4]arene (TC4A), and iron oxide nanoparticles (IONP) have been employed to construct a stable composition, which is named Thiacalix[4]arene-Xanthan Gum@ Iron Oxide Nanoparticles (TC4A-XG@IONP). The process used to fabricate this nanocatalyst includes the in-situ magnetization of XG, its amine modification by APTES to get NH2-XG@IONP hydrogel, the synthesis of TC4A, its functionalization with epichlorohydrine, and eventually its covalent attachment onto the NH2-XG@IONP hydrogel. The structure of the TC4A-XG@IONP was characterized by different analytical methods including Fourier-transform infrared spectroscopy, X-Ray diffraction analysis (XRD), Energy Dispersive X-Ray, Thermal Gravimetry analysis, Brunauer–Emmett–Teller, Field Emission Scanning Electron Microscope and Vibration Sample Magnetomete. With magnetic saturation of 9.10 emu g−1 and ~ 73% char yields, the TC4As-XG@IONP catalytic system demonstrated superparamagnetic property and high thermal stability. The magnetic properties of the TC4A-XG@IONP nanocatalyst system imparted by IONP enable it to be conveniently isolated from the reaction mixture by using an external magnet. In the XRD pattern of the TC4As-XG@IONP nanocatalyst, characteristic peaks were observed. This nanocatalyst is used as an eco-friendly, heterogeneous, and green magnetic catalyst in the synthesis of acridinedione derivatives through the one-pot pseudo-four component reaction of dimedone, various aromatic aldehydes, and ammonium acetate or aniline/substituted aniline. A combination of 10 mg of catalyst (TC4A-XG@IONP), 2 mmol of dimedone, and 1 mmol of aldehyde at 80 °C in a ethanol at 25 mL round bottom flask, the greatest output of acridinedione was 92% in 20 min.This can be attributed to using TC4A-XG@IONP catalyst with several merits as follows: high porosity (pore volume 0.038 cm3 g−1 and Pore size 9.309 nm), large surface area (17.306 m2 g−1), three dimensional structures, and many catalytic sites to active the reactants. Additionally, the presented catalyst could be reused at least four times (92–71%) with little activity loss, suggesting its excellent stability in this multicomponent reaction. Nanocatalysts based on natural biopolymers in combination with magnetic nanoparticles and macrocycles may open up new horizons for researchers in the field.

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Facile synthesis of pyrazolopyridine pharmaceuticals under mild conditions using an algin-functionalized silica-based magnetic nanocatalyst (Alg@SBA-15/Fe₃O₄)

Abstract: Pyrazolopyridines are common scaffolds in various bioactive compounds, which have several therapeutic effects and unique pharmacological properties.

Cited by 10 publications

References 58 publications

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Enhancement of adsorption efficiency of crystal violet and chlorpyrifos onto pectin hydrogel@Fe3O4-bentonite as a versatile nanoadsorbent

Utilizing magnetic xanthan gum nanocatalyst for the synthesis of acridindion derivatives via functionalized macrocycle Thiacalix[4]arene

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Facile synthesis of pyrazolopyridine pharmaceuticals under mild conditions using an algin-functionalized silica-based magnetic nanocatalyst (Alg@SBA-15/Fe3O4)

Abstract: Pyrazolopyridines are common scaffolds in various bioactive compounds, which have several therapeutic effects and unique pharmacological properties.

Cited by 10 publications

References 58 publications

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

DNA hydrogels and nanogels for diagnostics, therapeutics, and theragnostics of various cancers

Enhancement of adsorption efficiency of crystal violet and chlorpyrifos onto pectin hydrogel@Fe3O4-bentonite as a versatile nanoadsorbent

Utilizing magnetic xanthan gum nanocatalyst for the synthesis of acridindion derivatives via functionalized macrocycle Thiacalix[4]arene

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Facile synthesis of pyrazolopyridine pharmaceuticals under mild conditions using an algin-functionalized silica-based magnetic nanocatalyst (Alg@SBA-15/Fe₃O₄)