Facile Synthesis of Polyfunctional Indole-Pyrido[2,3-d]Pyrimidine Hybrids Using Nickel-Incorporated Fluorapatite Encapsulated Iron Oxide Nanocatalyst and Study of Their Antibacterial Activities

Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

“…The nal step of this proposed Compounds 34a-j (Scheme 25) were assessed as antibacterial agents against diverse bacterial species using tetracycline and ciprooxacin as standard antibiotics. The compounds revealed promising activities, for instance, compound 34g (Ar = 3-Cl-C 6 H 4 ) showed supreme effectiveness against S. aureus species (12 mg per well; 13 mm), which was similar to that of Dastmard et al 105 advanced an effectual method for the synthesis of tetrahydro-pyridopyrimidines incorporated in the indole core 35a-m under heating, and nano-catalytic conditions using Fe 3 O 4 @FAp@Ni. Thus, one-pot three-component reactions of 6-amino-1,3-dimethyl-pyrimidine-2,4(1H,3H)-dione with 3-cyanoacetyl-indole and aromatic aldehydes in ethanol gave the anticipated products 35a-m in good to excellent yields.…”

“…Also, compound 34b (Ar = 4-Cl-C 6 H 4 ) was the most potent antibacterial agent towards M. luteus species (20 mm), while the compounds displayed the least activity versus P. aeruginosa species (5-9 mm). Dastmard et al 105 advanced an effectual method for the synthesis of tetrahydro-pyridopyrimidines incorporated in the indole core 35a-m under heating, and nano-catalytic conditions using Fe 3 O 4 @FAp@Ni. Thus, one-pot three-component reactions of 6-amino-1,3-dimethyl-pyrimidine-2,4(1H,3H)-dione with 3-cyanoacetyl-indole and aromatic aldehydes in ethanol gave the anticipated products 35a-m in good to excellent yields.…”

“…Dastmard et al 105 advanced an effectual method for the synthesis of tetrahydro-pyridopyrimidines incorporated in the indole core 35a–m under heating, and nano-catalytic conditions using Fe 3 O 4 @FAp@Ni. Thus, one-pot three-component reactions of 6-amino-1,3-dimethyl-pyrimidine-2,4(1 H ,3 H )-dione with 3-cyanoacetyl-indole and aromatic aldehydes in ethanol gave the anticipated products 35a–m in good to excellent yields.…”

“…The electron-withdrawing substituents seemed to be more efficient antibacterial agents than the other substituents on the benzene ring. 105…”

“…The electronwithdrawing substituents seemed to be more efficient antibacterial agents than the other substituents on the benzene ring. 105 A series of 5-aryl-7-pyrrolyl-tetrahydropyrido [2,3-d]pyrimidine analogs 36a-s were prociently synthesized Ramezanzadeh et al 107 using ionic liquid supported on hydroxyapatiteencapsulated g-Fe 2 O 3 nano-catalyst. Accordingly, threecomponent one-pot reactions of aryl aldehydes with diaminopyrimidinone, and 1H-pyrrolyl-3-oxopropane-nitrile in ethanol yielded the respective bicyclic products 36.…”