Facile synthesis of MoS2@Cu2O-Pt nanohybrid as enzyme-mimetic label for the detection of the Hepatitis B surface antigen

Li, Faying; Li, Yueyun; Feng, Jinhui; Gao, Zhonghui; Lv, Hui; Ren, Xiang; Wei, Qin

doi:10.1016/j.bios.2017.09.048

Cited by 69 publications

(37 citation statements)

References 49 publications

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“…181 Wei et al also published a similar approach for the quantitative detection of hepatitis B surface antigen using MoS2@Cu2O-Pt nanozymes. 182 Although nanozyme-based sensors are well known for amplifying the readout signals (i.e.,"signal-on"), they can equally be useful in generating a noticeable change in electrochemical response in "signal-off" sandwich immunosensing strategies. This method generally involves a nanozyme catalyzed chemical reaction that forms a nonconducting precipitate on the electrode surface.…”

Section: Immunosensormentioning

confidence: 99%

Nanozyme-based electrochemical biosensors for disease biomarker detection

Mahmudunnabi

Farhana

Kashaninejad

et al. 2020

Analyst

149

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Section: Immunosensormentioning

confidence: 99%

Nanozyme-based electrochemical biosensors for disease biomarker detection

Mahmudunnabi

Farhana

Kashaninejad

et al. 2020

Analyst

149

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“…Figure 2 B shows the synthesis process of BSA-Ab2-Cu3(PO4)2hybrid nanoflowers and a schematic image of the technology. The characteristics of the completed electrochemical immunosensor are shown in Figure 2 C. As shown in Figure 2 C, a noticeable redox peak appears at 0.34 V and 0.14 V using the Cyclic Voltammetry (CV) technique [ 63 , 64 ], which is confirmed to result from electron transfer of Mo in molybdophosphate [ 65 , 66 ]. As no redox peak was found in the red and blue lines, it was confirmed that molybdophosphate forms redox currents due to the electron transfer of Mo.…”

Section: Electrochemical Biosensormentioning

confidence: 99%

Recent Advances in CRP Biosensor Based on Electrical, Electrochemical and Optical Methods

Noh

Kim

et al. 2021

Sensors

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C-reactive protein (CRP) is an acute-phase reactive protein that appears in the bloodstream in response to inflammatory cytokines such as interleukin-6 produced by adipocytes and macrophages during the acute phase of the inflammatory/infectious process. CRP measurement is widely used as a representative acute and chronic inflammatory disease marker. With the development of diagnostic techniques measuring CRP more precisely than before, CRP is being used not only as a traditional biomarker but also as a biomarker for various diseases. The existing commercialized CRP assays are dominated by enzyme-linked immunosorbent assay (ELISA). ELISA has high selectivity and sensitivity, but its limitations include requiring complex analytic processes, long analysis times, and professional manpower. To overcome these problems, nanobiotechnology is able to provide alternative diagnostic tools. By introducing the nanobio hybrid material to the CRP biosensors, CRP can be measured more quickly and accurately, and highly sensitive biosensors can be used as portable devices. In this review, we discuss the recent advancements in electrochemical, electricity, and spectroscopy-based CRP biosensors composed of biomaterial and nanomaterial hybrids.

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“…Next, silver nanoparticles (AgNPs) solution was deposited on the SPE and the Ag reduction was detected by linear sweep voltammetry (LVS) from −0.15 to 0.25 V at 50 mV s −1 in 1.0 M KCl solution [ 68 ] ( Figure 4 ). Following this, a variety of NPs were used for protein biomarker detection, including silver NPS [ 68 , 69 , 70 ], platinum NPs [ 71 , 72 , 73 , 74 ], palladium NPs [ 57 , 75 ], copper NPs [ 76 ], and iridium NPs [ 57 , 77 ].…”

Section: Immunoassay Techniques For Printed Electrodesmentioning

confidence: 99%

Printed Electrodes in Microfluidic Arrays for Cancer Biomarker Protein Detection

et al. 2020

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Medical diagnostics is trending towards a more personalized future approach in which multiple tests can be digitized into patient records. In cancer diagnostics, patients can be tested for individual protein and genomic biomarkers that detect cancers at very early stages and also be used to monitor cancer progression or remission during therapy. These data can then be incorporated into patient records that could be easily accessed on a cell phone by a health care professional or the patients themselves on demand. Data on protein biomarkers have a large potential to be measured in point-of-care devices, particularly diagnostic panels that could provide a continually updated, personalized record of a disease like cancer. Electrochemical immunoassays have been popular among protein detection methods due to their inherent high sensitivity and ease of coupling with screen-printed and inkjet-printed electrodes. Integrated chips featuring these kinds of electrodes can be built at low cost and designed for ease of automation. Enzyme-linked immunosorbent assay (ELISA) features are adopted in most of these ultrasensitive detection systems, with microfluidics allowing easy manipulation and good fluid dynamics to deliver reagents and detect the desired proteins. Several of these ultrasensitive systems have detected biomarker panels ranging from four to eight proteins, which in many cases when a specific cancer is suspected may be sufficient. However, a grand challenge lies in engineering microfluidic-printed electrode devices for the simultaneous detection of larger protein panels (e.g., 50–100) that could be used to test for many types of cancers, as well as other diseases for truly personalized care.

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Facile synthesis of MoS2@Cu2O-Pt nanohybrid as enzyme-mimetic label for the detection of the Hepatitis B surface antigen

Cited by 69 publications

References 49 publications

Nanozyme-based electrochemical biosensors for disease biomarker detection

Nanozyme-based electrochemical biosensors for disease biomarker detection

Recent Advances in CRP Biosensor Based on Electrical, Electrochemical and Optical Methods

Printed Electrodes in Microfluidic Arrays for Cancer Biomarker Protein Detection

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