Facile synthesis of monodisperse chromogenic amylose–iodine nanoparticles as an efficient broad-spectrum antibacterial agent

Sun, Y. K.; Wang, Xianwen; Fan, Linxin; Xie, Xianli; Miao, Zhaohua; Ma, Yan; He, Tao; Zha, Zhengbao

doi:10.1039/d0tb00161a

Cited by 11 publications

(4 citation statements)

References 42 publications

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“…The term nanoparticle refers to any natural or artificial structure, including tubes and fibers, with external dimensions between 1 and 100 nanometers (nm) [7][8][9]. A spectrum of technologies enables nanoparticles to be manufactured and engineered with a specific synthetic (material-intrinsic) identity including rational coating of their surface to facilitate specific applications including tissue targeting in biomedical applications (Table 1, column 2) [10][11][12][13]. For example, nanoparticles that have been covalently linked to macromolecules such as polyethylene glycol, antibodies or peptides are designed to ensure desirable levels of solubility, stability or biological activity in drug delivery (Table 1, columns 1-3).…”

Section: Artificial Nanoparticles and Their 'Acquired Protein Coronas'mentioning

confidence: 99%

Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity?

Hardy¹,

Sarker²,

Fernández-Patrón³

2023

Preprint

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We advance the notion that much, like artificial nanoparticles, relatively more complex biological entities with nanometric dimensions such as pathogens (viruses, bacteria and other microorganisms) may also acquire a biomolecular corona, upon entering the blood circulation of an organism. We view this biomolecular corona as a component of a much broader non-cellular blood interactome that can be highly specific to the organism, akin to components of the innate immune response to an invading pathogen. We review published supporting data and generalize these notions from artificial nanoparticles to viruses and bacteria. Characterization of the non-cellular blood interactome of an organism may help explain apparent differences in the susceptibility to pathogens among individuals. The non-cellular blood interactome is a candidate therapeutic target to treat infectious and non-infectious conditions.

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Section: Artificial Nanoparticles and Their 'Acquired Protein Coronas'mentioning

confidence: 99%

Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity?

Hardy¹,

Sarker²,

Fernández-Patrón³

2023

Preprint

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“…Nanomaterials have attracted great attention in the last two decades for antibacterial applications. − For instance, compared to bulk silver materials, silver nanoparticles exhibit enhanced bactericidal effect due to the rapid release of Ag + and direct interaction with the bacterial surface . In more recent years, several researches reported the preparation of various iodine-containing antimicrobial materials with nanotechnology. − Nevertheless, in previous studies, iodine has to be complexed with polymers to improve its low water solubility and suppress its easy sublimation. In 2020, Qian et al demonstrated that it is feasible to synthesize two-dimensional (2D) iodine nanomaterials from bulk iodine, which is the only halide element possessing a 2D nanostructure ever reported .…”

Section: Introductionmentioning

confidence: 99%

Iodinene Nanosheet-to-Iodine Molecule Allotropic Transformation for Antibiosis

et al. 2023

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Iodine, as a typical haloid element in group VIIA, has been extensively applied as antiseptics clinically, thanks to its effective and wide-spectrum antimicrobial activity against bacteria, fungi, and viruses. Nevertheless, current iodic sterilizing agents are still limited to topical applications such as instrument sterilization and treatments of skin or mucous membrane infection due to its unsatisfactory stability and biocompatibility. Here, we propose an emerging two-dimensional iodine nanomaterial (noted as iodinene) for the treatment of infection diseases in vivo. Iodinene nanosheets were fabricated by a facile and environmentally friendly approach via sonication-assisted liquid exfoliation, which present an intriguing layered structure and negligible toxicity. The as-synthesized iodinene would experience an in situ allotropic transformation spontaneously to release active HIO and I2 molecules by reacting with H2O2 in the infectious microenvironment. By the in situ production of active HIO and I2 molecules via allotropic transformation, iodinene presents enhanced antibacterial efficacy against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. In vivo outcome demonstrates the desirable antibacterial efficacy of iodinene in treating bacterial wound infection and pneumonia. This study thus offers an alternative to conventional sterilizing agents against hard-to-treat bacterial infections.

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“…Implementing necessary protective measures, such as elimination and isolation, can be effective [11][12][13]. Iodine has been proven to be a highly effective fungicide and can be used to disinfect air environments [14][15][16][17][18][19]. It can achieve a killing rate of 99.999% at 25 • C for a duration of 10 min under standard conditions, with intestinal bacteria, amoebic cysts, and enteroviruses requiring 0.2 ppm, 3.5 ppm, and 14.6 ppm iodine residues, respectively [20].…”

Section: Introductionmentioning

confidence: 99%

Asymmetrical Methylene-Bridge Linked Fully Iodinated Azoles as Energetic Biocidal Materials with Improved Thermal Stability

Zhao

Zhang

et al. 2023

IJMS

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The instability and volatility of iodine is high, however, effective iodine biocidal species can be readily stored in iodinated azoles and then be released upon decomposition or detonation. Iodine azoles with high iodine content and high thermal stability are highly desired. In this work, the strategy of methylene bridging with asymmetric structures of 3,4,5-triiodo-1-H-pyrazole (TIP), 2,4,5-triiodo-1H-imidazol (TIM), and tetraiodo-1H-pyrrole (TIPL) are proposed. Two highly stable fully iodinated methylene-bridged azole compounds 3,4,5-triiodo-1-((2,4,5-triiodo-1H-imidazol-1-yl)methyl)-1H-pyrazole (3) and 3,4,5-triiodo-1-((tetraiodo-1H-pyrrol-1-yl)methyl)-1H-pyrazole (4) were obtained with high iodine content and excellent thermal stability (iodine content: 84.27% for compound 3 and 86.48% for compound 4; Td: 3: 285 °C, 4: 260 °C). Furthermore, their composites with high-energy oxidant ammonium perchlorate (AP) were designed. The combustion behavior and thermal decomposition properties of the formulations were tested and evaluated. This work may open a new avenue to develop advanced energetic biocidal materials with well-balanced energetic and biocidal properties and versatile functionality.

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Facile synthesis of monodisperse chromogenic amylose–iodine nanoparticles as an efficient broad-spectrum antibacterial agent

Abstract: Monodisperse chromogenic amylose–iodine nanoparticles were developed as an efficient broad-spectrum antibacterial agent under the assistance of near-infrared laser irradiation.

Cited by 11 publications

References 42 publications

Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity?

Could a Non-Cellular Molecular Interactome in the Blood Circulation Influence Pathogens’ Infectivity?

Iodinene Nanosheet-to-Iodine Molecule Allotropic Transformation for Antibiosis

Asymmetrical Methylene-Bridge Linked Fully Iodinated Azoles as Energetic Biocidal Materials with Improved Thermal Stability

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