Iodinene Nanosheet-to-Iodine Molecule Allotropic Transformation for Antibiosis

You, Yong; Zhu, Ya‐Xuan; Jiang, Junjie; Chen, Zhuo; Wu, Chen-Chou; Zhang, Zhimin; Han, Lin; Shi, Jianlin

doi:10.1021/jacs.3c02669

Cited by 19 publications

(7 citation statements)

References 49 publications

(79 reference statements)

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“…Biomaterials have been a focus in the field of antimicrobial research, primarily due to the increasing prevalence of antibiotic-resistant bacteria. − Current biomaterials have shifted the emphasis of immune-modulating antimicrobial strategies toward adaptive immunity, highlighting the growing attention on the role of adaptive immunity in implant infections. , However, the challenge remains in how to enhance adaptive immune responses in the implant-associated infections. But perhaps it could be inspired by tumor-related immunity.…”

Section: Resultsmentioning

confidence: 99%

Targeted Light-Induced Immunomodulatory Strategy for Implant-Associated Infections via Reversing Biofilm-Mediated Immunosuppression

Jiang,

Wang,

Ren

et al. 2024

ACS Nano

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The clinical treatment efficacy for implant-associated infections (IAIs), particularly those caused by Methicillin-resistant Staphylococcus aureus (MRSA), remains unsatisfactory, primarily due to the formation of biofilm barriers and the resulting immunosuppressive microenvironment, leading to the chronicity and recurrence of IAIs. To address this challenge, we propose a light-induced immune enhancement strategy, synthesizing BSA@MnO 2 @Ce6@Van (BMCV). The BMCV exhibits precise targeting and adhesion to the S. aureus biofilm-infected region, coupled with its capacity to catalyze oxygen generation from H 2 O 2 in the hypoxic and acidic biofilm microenvironment (BME), promoting oxygen-dependent photodynamic therapy efficacy while ensuring continuous release of manganese ions. Notably, targeted BMCV can penetrate biofilms, producing ROS that degrade extracellular DNA, disrupting the biofilm structure and impairing its barrier function, making it vulnerable to infiltration and elimination by the immune system. Furthermore, light-induced reactive oxygen species (ROS) around the biofilm can lyse S. aureus, triggering bacterium-like immunogenic cell death (ICD), releasing abundant immune costimulatory factors, facilitating the recognition and maturation of antigenpresenting cells (APCs), and activating adaptive immunity. Additionally, manganese ions in the BME act as immunoadjuvants, further amplifying macrophage-mediated innate and adaptive immune responses and reversing the immunologically cold BME to an immunologically hot BME. We prove that our synthesized BMCV elicits a robust adaptive immune response in vivo, effectively clearing primary IAIs and inducing long-term immune memory to prevent recurrence. Our study introduces a potent light-induced immunomodulatory nanoplatform capable of reversing the biofilm-induced immunosuppressive microenvironment and disrupting biofilm-mediated protective barriers, offering a promising immunotherapeutic strategy for addressing challenging S. aureus IAIs.

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Section: Resultsmentioning

confidence: 99%

Targeted Light-Induced Immunomodulatory Strategy for Implant-Associated Infections via Reversing Biofilm-Mediated Immunosuppression

Jiang,

Wang,

Ren

et al. 2024

ACS Nano

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Section: Nanomedicine-enabled Rhs Generation and Eliminationmentioning

confidence: 99%

Section: Nanomedicine‐enabled Rhas Generationmentioning

confidence: 99%

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Nanomedicine‐Enabled Chemical Regulation of Reactive X Species for Versatile Disease Treatments

Dai,

Xie,

Feng

et al. 2023

Angew Chem Int Ed

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Reactive X species (RXS), encompassing elements such as O, N, C, S, Se, Cl, Br, I, and H, play vital roles in cell biology and physiological function, impacting cellular signal transduction, metabolic regulation and disease processes. The redox unbalance of RXS is firmly implicated in an assortment of physiological and pathological disorders, including cancer, diabetes, cardiovascular disease, and neurodegenerative diseases. However, the intricate nature and multifactorial dependence of RXS pose challenges in comprehending and precisely modulating their biological behavior. Nanomaterials with distinct characteristics and biofunctions offer promising avenues for generating or scavenging RXS to maintain redox homeostasis and advance disease therapy. This minireview provides a tutorial summary of the relevant chemistry and specific mechanisms governing different RXS, focusing on cellular metabolic regulation, stress responses, and the role of nanomedicine in RXS generation and elimination. The challenges associated with chemically regulating RXS for diverse disease treatments are further discussed along with the future prospects, aiming to facilitate the clinical translation of RXS‐based nanomedicine and open new avenues for improved therapeutic interventions.

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“…2 Bacterial attachment leads to infections that scholars try to address by improving the antimicrobial and anti-inflammatory properties of biomaterials. Such efforts have yielded polymers, 3,4 nanosheets, 5 and engineered bacteria 6 with desired bactericidal effects. However, these technologies fall short of effectively removing dental plaque, the initiating factor of periodontitis, on a large scale.…”

Section: Introductionmentioning

confidence: 99%

Magnetic Hydroxyapatite-Coated Iron–Chromium Microspheres for Dental Surface Polishing and Plaque Removal

Jiang,

Sun,

et al. 2024

ACS Appl. Mater. Interfaces

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This research aimed to engineer magnetic hydroxyapatitecoated iron−chromium (HAp−FeCr) microspheres to enhance dental surface polishing and plaque elimination. Utilizing a tailored sol−gel approach, the HAp−FeCr microspheres were synthesized and exhaustively characterized via scanning electron microscopy, energy-dispersive X-ray spectroscopy, ζpotential, X-ray diffractometry, and X-ray photoelectron spectroscopy methodologies. Key findings showcased that these microspheres retained their magnetic properties post-HAp coating, as evidenced by the magnetization curves. An innovative magnetic polishing system was developed, incorporating these microspheres and a 2000 rpm magnet. Comparative evaluations between traditional air-powder polishing and the proposed magnetic technique demonstrated the latter's superiority. Notably, the magnetic polishing led to a substantial reduction in dental plaque on the tooth surface, decreasing bacterial adhesion and early biofilm formation by Streptococcus gordonii and Lactobacillus acidophilus, where the most pronounced effects were observed in samples with elevated HAp content. A significant 60% reduction in dental plaque was achieved with the magnetic method relative to air-powder polishing. Furthermore, the HAp−FeCr microspheres' biocompatibility was verified through cytotoxicity tests and animal studies. In essence, the magnetic HAp−FeCr microspheres present a novel and efficient strategy for dental treatments, holding immense potential for improving oral health.

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Iodinene Nanosheet-to-Iodine Molecule Allotropic Transformation for Antibiosis

Cited by 19 publications

References 49 publications

Targeted Light-Induced Immunomodulatory Strategy for Implant-Associated Infections via Reversing Biofilm-Mediated Immunosuppression

Targeted Light-Induced Immunomodulatory Strategy for Implant-Associated Infections via Reversing Biofilm-Mediated Immunosuppression

Nanomedicine‐Enabled Chemical Regulation of Reactive X Species for Versatile Disease Treatments

Magnetic Hydroxyapatite-Coated Iron–Chromium Microspheres for Dental Surface Polishing and Plaque Removal

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