Facile synthesis of magnetic hierarchical flower-like Co3O4 spheres: Mechanism, excellent tetra-enzyme mimics and their colorimetric biosensing applications

Li, Xuan; Lü, Yan; Ren, Han; Cai, Yuanyuan; Liu, Chongyang; Ling, Zeng; Guo, Jing; Liu, Aihua

doi:10.1016/j.bios.2020.112342

Cited by 133 publications

(75 citation statements)

References 44 publications

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“…The exploration of biomarkers is beneficial to clinical diagnosis, drug analysis and ecosystem protection. Enormous effort has been made in nanozyme-based biomarker detecting, including biological macromolecules (e.g., acid phosphatase (ACP) for prostate cancer [ 149 ]; human epidermal growth factor receptor-2 (HER2) for breast cancer [ 294 , 295 ]; carcinoembryonic antigen (CEA) for rectal cancer [ 296 , 297 ] and benzo[ a ]pyrene-7,8-diol 9,10-epoxide–DNA (BPDE–DNA) for woodsmoke exposure [ 298 ]) and small molecule biomarkers (e.g., sarcosine for prostate cancer [ 299 ] and uric acid [ 300 ]). Pedone et al [ 301 ] developed a colorimetric approach to determine the total antioxidant capacity (TAC) in saliva on basis of the reaction between antioxidants and H 2 O 2 in the presence of Pt nanozymes, which was acted as POD mimics.…”

Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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“…OH, and NaN 3 as a scavenger for free 1 O 2 did not induce obvious changes in absorbance, therefore free . OH and 1 O 2 were not present (Figure S9A) [6d] . Superoxide dismutase (SOD) and nitro blue tetrazolium chloride (NBT) were widely used as specific scavengers for superoxide radical ion O 2 .− [6d,25] .…”

Section: Resultsmentioning

confidence: 99%

“…OH and 1 O 2 were not present (Figure S9A) [6d] . Superoxide dismutase (SOD) and nitro blue tetrazolium chloride (NBT) were widely used as specific scavengers for superoxide radical ion O 2 .− [6d,25] . The addition of SOD led to a notable inhibition of ABTS oxidation.…”

Section: Resultsmentioning

confidence: 99%

Amplified Peroxidase‐like Activity of Co²⁺ Using 8‐Hydroxyquinoline and Its Application for Ultrasensitive Colorimetric Detection of Clioquinol

Sai

Xue

et al. 2021

Chemistry An Asian Journal

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8‐Hydroxyquinoline (8HQ) and its derivatives display diverse bioactivities and therapeutic potentials. In this study, we unveiled that 8HQ can boost the peroxidase‐like activity of Co2+ in the presence of bicarbonate (HCO3−) in neutral pH at room temperature. With 2,2′‐azino‐bis‐(3‐ethylbenzothiazoline‐6‐sulphonate) (ABTS) as the substrate, the formed Co2+/8HQ/HCO3− complex shows robust catalytic activity with the turnover number (kcat) tens to hundreds of times higher than that of Co3O4 and other Co2+ complexes in terms of per cobalt ion. This system was used to design colorimetric sensors for ultrasensitive detection of 8HQ‐based drugs by activating the activity of Co2+. Take detecting clioquinol as an example, a detection limit of 2.4 nM clioquinol with a linear range from 0.01 to 0.2 μM was obtained. This work not only revealed a new kind of ligand that activated the activity of Co2+, but also provided a facile, low‐cost, ultrasensitive, easy‐to‐use, and universal strategy for sensing various 8HQ‐based drugs. Further development of this catalytic system might be beneficial to overcome drug resistance by combined medication.

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“…These good abilities make them an excellent choice in synthesizing nanoenzymes [ 1 ]. Among these materials, Co 3 O 4, a kind of intrinsic p-type transition metal oxide, was reported in electrochemically detecting H 2 O 2 because of its high electrochemical stability, fair price, and environmentally friendly [ 23 ]. However, the close-packed structures and poor electronic conductivity of Co 3 O 4 could reduce their specific surface area and deteriorate its performance in H 2 O 2 detection.…”

Section: Introductionmentioning

confidence: 99%

Co3O4 Nanoparticles Uniformly Dispersed in Rational Porous Carbon Nano-Boxes for Significantly Enhanced Electrocatalytic Detection of H2O2 Released from Living Cells

Xiong

Zhang

et al. 2022

IJMS

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A facile and ingenious method to chemical etching-coordinating a metal-organic framework (MOF) followed by an annealing treatment was proposed to prepare Co3O4 nanoparticles uniformly dispersed in rational porous carbon nano-boxes (Co3O4@CNBs), which was further used to detect H2O2 released from living cells. The Co3O4@CNBs H2O2 sensor delivers much higher sensitivity than non-etching/coordinating Co3O4, offering a limit of detection of 2.32 nM. The wide working range covers 10 nM-359 μM H2O2, while possessing good selectivity and excellent reproducibility. Moreover, this biosensor was used to successfully real-time detect H2O2 released from living cells, including both healthy and tumor cells. The excellent performance holds great promise for Co3O4@CNBs’s applications in electrochemical biomimetic sensing, particularly real-time monitor H2O2 released from living cells.

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Facile synthesis of magnetic hierarchical flower-like Co3O4 spheres: Mechanism, excellent tetra-enzyme mimics and their colorimetric biosensing applications

Cited by 133 publications

References 44 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Amplified Peroxidase‐like Activity of Co²⁺ Using 8‐Hydroxyquinoline and Its Application for Ultrasensitive Colorimetric Detection of Clioquinol

Co3O4 Nanoparticles Uniformly Dispersed in Rational Porous Carbon Nano-Boxes for Significantly Enhanced Electrocatalytic Detection of H2O2 Released from Living Cells

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Facile synthesis of magnetic hierarchical flower-like Co3O4 spheres: Mechanism, excellent tetra-enzyme mimics and their colorimetric biosensing applications

Cited by 133 publications

References 44 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Amplified Peroxidase‐like Activity of Co2+ Using 8‐Hydroxyquinoline and Its Application for Ultrasensitive Colorimetric Detection of Clioquinol

Co3O4 Nanoparticles Uniformly Dispersed in Rational Porous Carbon Nano-Boxes for Significantly Enhanced Electrocatalytic Detection of H2O2 Released from Living Cells

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Amplified Peroxidase‐like Activity of Co²⁺ Using 8‐Hydroxyquinoline and Its Application for Ultrasensitive Colorimetric Detection of Clioquinol