Facile synthesis of gelatin-coated Fe3O4 nanoparticle: Effect of pH in single-step co-precipitation for cancer drug loading

Sirivat, Anuvat; Paradee, Nophawan

doi:10.1016/j.matdes.2019.107942

Cited by 75 publications

(41 citation statements)

References 37 publications

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“…Figure 1A exhibited a result which is similar to the observation reported by previous study [33]. The bundling structure ( Figure 1B) suggests the other way around forming Fe 3 O 4 slender structures like nanowire array without the need for any precipitation and a subsequent microwave hydrothermal process, as reported in the previous study [34]. The agglomeration of the nanocrystals ( Figure 1C) might be due to the evaporation of water during the sample preparation [35].…”

Section: Detection Of Pcr Product Of Mycobacterium Tuberculosissupporting

confidence: 87%

DNA Electrochemical Biosensor Based on Iron Oxide/Nanocellulose Crystalline Composite Modified Screen-Printed Carbon Electrode for Detection of Mycobacterium tuberculosis

et al. 2020

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Death from tuberculosis has resulted in an increased need for early detection to prevent a tuberculosis (TB) epidemic, especially in closed and crowded populations. Herein, a sensitive electrochemical DNA biosensor based on functionalized iron oxide with mercaptopropionic acid (MPA-Fe3O4) nanoparticle and nanocellulose crystalline functionalized cetyl trimethyl ammonium bromide (NCC/CTAB) has been fabricated for the detection of Mycobacterium tuberculosis (MTB). In this study, a simple drop cast method was applied to deposit solution of MPA-Fe3O4/NCC/CTAB onto the surface of the screen-printed carbon electrode (SPCE). Then, a specific sequence of MTB DNA probe was immobilized onto a modified SPCE surface by using the 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling mechanism. For better signal amplification and electrochemical response, ruthenium bipyridyl Ru(bpy)32+ was assigned as labels of hybridization followed by the characteristic test using differential pulse voltammetry (DPV). The results of this biosensor enable the detection of target DNA until a concentration as low as 7.96 × 10−13 M with a wide detection range from 1.0 × 10−6 to 1.0 × 10−12 M. In addition, the developed biosensor has shown a differentiation between positive and negative MTB samples in real sampel analysis.

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Section: Detection Of Pcr Product Of Mycobacterium Tuberculosissupporting

confidence: 87%

DNA Electrochemical Biosensor Based on Iron Oxide/Nanocellulose Crystalline Composite Modified Screen-Printed Carbon Electrode for Detection of Mycobacterium tuberculosis

et al. 2020

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“…The organic phase (Eucalyptus essential oil) was introduced in the precipitation medium to form micelles, limiting the nucleation stage of nanoparticles and ensuring a better control of their growth and dimension [ 79 , 80 ]. The molecules of EG essential oil also acted as an in situ functionalizing agent by establishing weak interactions with the abundant hydroxyl groups on the surface of nanoparticles [ 81 , 82 ]. The synthesized iron oxide powder was subjected to characterization by means of composition, crystallinity and morphology.…”

Section: Resultsmentioning

confidence: 99%

MAPLE Coatings Embedded with Essential Oil-Conjugated Magnetite for Anti-Biofilm Applications

et al. 2021

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The present study reports on the development and evaluation of nanostructured composite coatings of polylactic acid (PLA) embedded with iron oxide nanoparticles (Fe3O4) modified with Eucalyptus (Eucalyptus globulus) essential oil. The co-precipitation method was employed to synthesize the magnetite particles conjugated with Eucalyptus natural antibiotic (Fe3O4@EG), while their composition and microstructure were investigated using grazing incidence X-ray diffraction (GIXRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), transmission electron microscopy (TEM) and dynamic light scattering (DLS). The matrix-assisted pulsed laser evaporation (MAPLE) technique was further employed to obtain PLA/Fe3O4@EG thin films. Optimal experimental conditions for laser processing were established by complementary infrared microscopy (IRM) and scanning electron microscopy (SEM) investigations. The in vitro biocompatibility with eukaryote cells was proven using mesenchymal stem cells, while the anti-biofilm efficiency of composite PLA/Fe3O4@EG coatings was assessed against Gram-negative and Gram-positive pathogens.

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“…Moreover, gelatin can be used as a matrix for drugs/genes or therapeutic ions, which can provide a controlled local release of drugs or therapeutic ions with the dissolution of gelatin. For instance, Sirivat and Paradee [58] utilized gelatin-coated Fe3O4 nanoparticles for cancer drug mercaptopurine delivery. Rahmanian et al [59] prepared gelatin-tricalcium phosphate scaffold for loading with the zoledronic acid drug.…”

Section: Resultsmentioning

confidence: 99%

PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

Baştan

2021

Eskişehir Technical University Journal of Science and Technology a - Applied Sciences and Engineering

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In this study, composite hydroxyapatite (HA)-gelatin microspheres (SD-HA-Gel) were produced for bone substitution applications. The polymer network within the HA matrix would be facilitated as a drug carrier system and can develop the cellmicrosphere interactions due to the excellent biological properties of gelatin. Gelatin functionalized HA microspheres and bare HA granules (as a reference) with 8 µm average size were produced by spray drying process. The morphology, thermal properties, chemical and phase structure of the produced powders were analyzed by SEM, TG-DTA, FTIR and XRD methods. SD-HA-Gel microspheres presented spherical morphology and hollow/core-shell cross-section and consisted of HA nanoparticles and gelatin molecules together according to the SEM, FTIR and XRD studies. Thermal analyze results showed that gelatin evolved from the microspheres at ~300 °C. The effect of gelatin on the crystallization and high temperature stability of HA was studied by XRD analysis and Rietveld Refinement investigations. Gelatin was released from the microspheres after immersion for 14 days in phosphate buffer saline (PBS) solution.

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Facile synthesis of gelatin-coated Fe3O4 nanoparticle: Effect of pH in single-step co-precipitation for cancer drug loading

Cited by 75 publications

References 37 publications

DNA Electrochemical Biosensor Based on Iron Oxide/Nanocellulose Crystalline Composite Modified Screen-Printed Carbon Electrode for Detection of Mycobacterium tuberculosis

DNA Electrochemical Biosensor Based on Iron Oxide/Nanocellulose Crystalline Composite Modified Screen-Printed Carbon Electrode for Detection of Mycobacterium tuberculosis

MAPLE Coatings Embedded with Essential Oil-Conjugated Magnetite for Anti-Biofilm Applications

PRODUCTION and CHARACTERIZATION of GELATIN FUNCTIONALIZED HYDROXYAPATITE COMPOSITE MICROSPHERES for BIOMEDICAL APPLICATIONS

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