Facile Synthesis of Fluorescent Latex Nanoparticles with Selective Binding Properties Using Amphiphilic Glycosylated Polypeptide Surfactants

Abstract

. (2014). Facile synthesis of fluorescent latex nanoparticles with selective binding properties using amphiphilic glycosylated polypeptide surfactants. Biomacromolecules, 47(21), 7303-7310.

Surface structure and composition of narrowly-distributed functional polystyrene particles prepared by dispersion polymerization with poly(l-glutamic acid) macromonomer as stabilizer

“…The increase in the n value resulted in an enlargement of the particles from D n ¼ 1.06 to 1.99 mm, indicating that the use of a larger mPLGA n produced a smaller number of stable particles. Because weight percentage of the mPLGA n concentration was the same at 0.50 wt%, mole percentage of the mPLGA 550 was 34 times smaller than that of the mPLGA 15 , which is responsible for the decrease in the stable particles. In addition, it is reasonable to assume that the large soluble PLGA segment enhanced solubility of the graft copolymer in the dispersion medium and, thus, weakened its adsorption.…”

Thermoresponsive glycopolypeptides with temperature controlled selective lectin binding properties

“…As a result, polypeptides promise potential in biomedical fields such as drug delivery [16][17][18][19][20][21], tissue engineering [22] or imaging [23]. The synthesis of glycosylated polypeptides has been achieved using direct polymerization of glycosylated NCA or post-modification by conventional chemistry as well as click chemistry [24][25][26][27][28][29][30][31]. On the other hand, a range of thermoresponsive polypeptides have been described in the literature [21,[32][33][34][35].…”

Amphiphilic glycosylated block copolypeptides as macromolecular surfactants in the emulsion polymerization of styrene

“…39 Batch emulsion polymerizations were all carried out in a three-neck reactor equipped with a reflux condenser, nitrogen inlet and mechanical stirrer. 39 Batch emulsion polymerizations were all carried out in a three-neck reactor equipped with a reflux condenser, nitrogen inlet and mechanical stirrer.…”

“…40 Phenyl-L-alanine (PA) was chosen as the amino acid for this block due to the structural resemblance of the phenyl substituent with styrene. 39 To enhance amphiphilicity, the deprotected poly(L-glutamic acid) (PGA) and poly(L-lysine) (PLL) blocks were glycosylated using previously reported strategies. PBLG 60 -b-PPA 20 (1) and PZLL 59 -b-PPA 24 (3) in DMF at 0°C under vacuum using allylamine as an initiator.…”

“…Initially, two different diblock copolymers were synthesised by sequential NCA polymerisation from poly(benzyl-L-glutamate) (PBLG) and poly(Z-L-lysine) (PZLL), respectively (Scheme 1), i.e. 33,39 The lysine residues of PLL 59 -b-PPA 24 were coupled with lactobionic acid (LA) using traditional EDC/NHS coupling chemistry (Scheme 1) targeting 30% glycosylation (LA 17 -r-PLL 42 -b-PPA 24 , 4). 11 Due to the insolubility of PPA in DMF it was necessary to first prepare the PBLG or PZLL block to prevent precipitation.…”