Facile synthesis of agarose-l-phenylalanine ester hydrogels

Mehta, Gaurav K.; Kondaveeti, Stalin; Siddhanta, A. K.

doi:10.1039/c1py00250c

Cited by 29 publications

(18 citation statements)

References 37 publications

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“…Na‐CMA and Ca‐CMA having DS 0.27 produced the stronger gel in water compared with their higher DS, which may be due to the limited presence of CM functional groups on the Ag backbone, thus assisting the formation of hydrogel networks through hydrogen bonding as well as because of the increase in number of “junction zones” in the gel network. The results are in good agreement with the literature reports of Ag derivatives . Result of this study revealed that the modification technique used in this study produced quick soluble and low gelling and melting Ag‐based hydrogels with low thermal hysteresis compared with parent Ag, which may be useful for some specific applications .…”

Section: Resultssupporting

confidence: 91%

“…This is in good agreement with the literature reports . In addition, in the FT‐IR spectrum of Na/Ca‐CMA, the main characteristic absorption bands of Ag (1162, 1073, and 931 cm −1 ) remained intact during modification reaction indicating that the backbone of Ag remains as such during chemical modification as shown in Figure (a,b) . The characteristic IR bands of MCA were obtained at 1733 cm −1 (sharp; CO, stretching vibration of carbonyl group of acid) and 1305 cm −1 (weak; CH 2 , scissoring in the CM group) as shown in Figure (c).…”

Section: Resultssupporting

confidence: 90%

“…In addition, 13 C‐NMR of Na/Ca‐CMA showed other prominent peaks at 62.7 ppm (C‐6′, linked with MCA) and 62.3 ppm (C6′* CH 2 linked with OH in unreacted Ag) (Figure ). 13 C‐NMR of the parent Ag exhibits the characteristic peaks of Ag polymer between 62.1 and 103.1 ppm . Similarly, characteristic 13 C‐NMR peaks of MCA were obtained at 172.3 ppm (CO/C a ) and 42.5 ppm (CH 2 /C b ) as shown in Figure .…”

Section: Resultsmentioning

confidence: 63%

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Preparation and functional evaluation of agarose derivatives

Chaudhary

Kondaveeti

Gupta

et al. 2014

J of Applied Polymer Sci

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A facile microwave‐assisted one‐pot synthesis of sodium carboxymethylagarose and calcium carboxymethylagarose from Gracilaria dura agarose (Ag) has been described. The process is user friendly, and the highest degree of substitution was obtained within 15 min compared with the conventional method, which requires more than 3 h. Solubility and gelling behavior of the modified Ag products were found to be dependent on degree of substitution of the products. The characterizations were done by using Fourier transform infrared spectroscopy, 1H‐ and 13C‐nuclear magnetic resonance spectroscopy, thermogravimetric analysis, scanning electron microscopy, Inductively coupled plasma spectrophotometry (ICP), rheology, conductometer analysis, and DNA gel electrophoresis. These agarose derivatives were easily soluble in water and exhibited low thermal hysteresis, improved conductivity, and improved the DNA resolution ability of the parent G. dura Ag hydrogels. These hydrogels may have potential applications in the areas including electrochemical devices, microbiology, biomedical, and pharmaceuticals fields. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40630.

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Section: Resultssupporting

confidence: 91%

Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 63%

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Preparation and functional evaluation of agarose derivatives

Chaudhary

Kondaveeti

Gupta

et al. 2014

J of Applied Polymer Sci

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“…In addition, the functionalization was confirmed by comparing the FTIR spectra of pure and modified AG samples (Figure ). Absorption peaks at

\overset{ν}{true}

=1740 (C=O stretching vibration of ester) and 1645 cm −1 (H−O−H stretching vibration of bound water) confirms acetylation of AG. On the other hand, the characteristic absorption peaks at

\overset{ν}{true}

=1725 cm −1 for the C=O ester,

\overset{ν}{true}

=1234 and 743 cm −1 for the C−N carbamate stretching, and

\overset{ν}{true}

=1603 cm −1 for the phenyl skeleton confirmed the carbanilation of AG.…”

Section: Resultsmentioning

confidence: 89%

“…Like pure AG, CAG formed a hydrogel with a comparative gelling and melting temperature; however, the gel strength was a bit lower in the case of the CAG hydrogel (750 g cm −2 and 680 g cm −2 for AG and CAG respectively; see Table S3 in the Supporting Information). The lower gel strength in the case of CAG may be because of the reduction of hydrogen‐bonding sites and the weaker double‐helix structure after functionalization . As a result of the highly hydrophobic character, AAG did not dissolve in water and, thus, a hydrogel was not formed.…”

Section: Resultsmentioning

confidence: 99%

Functionalized Agarose Self‐Healing Ionogels Suitable for Supercapacitors

et al. 2015

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Agarose has been functionalized (acetylated/carbanilated) in an ionic liquid (IL) medium of 1-butyl-3-methylimidazolium acetate at ambient conditions. The acetylated agarose showed a highly hydrophobic nature, whereas the carbanilated agarose could be dissolved in water as well as in the IL medium. Thermoreversible ionogels were obtained by cooling the IL sols of carbanilated agarose at room temperature. The ionogel prepared from a protic-aprotic mixed-IL system (1-butyl-3-methylimidazolium chloride and N-(2-hydroxyethyl)ammonium formate) demonstrated a superior self-healing property, as confirmed from rheological measurements. The superior self-healing property of such an ionogel has been attributed to the unique inter-intra hydrogen-bonding network of functional groups inserted in the agarose. The ionogel was tested as a flexible solid electrolyte for an activated-carbon-based supercapacitor cell. The measured specific capacitance was found to be comparable with that of a liquid electrolyte system at room temperature and was maintained for up to 1000 charge-discharge cycles. Such novel functionalized-biopolymer self-healing ionogels with flexibility and good conductivity are desirable for energy-storage devices and electronic skins with superior lifespans and robustness.

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Bioprinting of Thermoresponsive Hydrogels for Next Generation Tissue Engineering: A Review

Suntornnond

Chua

2016

Macromol. Mater. Eng.

155

149

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Bioprinting is a breakthrough technology that integrates living cells, biomaterials, and a robotic dispensing system to create complex structures that mimic original tissues and organs. One of the main components of bioprinting is bioink and hydrogel is essential in bioink formulation. In bioprinting, hydrogel should have good biocompatibility, provide good resolution, and have sufficient mechanical strength to support printed structures. Recently, thermoresponsive hydrogels have gained more and more attention due to their unique characteristic of tunable sol-gel (liquid to solid phase) transition when temperature is changed, and many biomedical applications from drug delivery devices to tissue scaffolds have demonstrated the potentials of bioprinted thermosresponsive constructs. In this review, we discuss bioprintable thermoresponsive hydrogels with a particular focus on their gelation mechanisms, fabrication strategies using bioprinter and applications. The future prospects of the bioprinting-based use of thermoresponsive hydrogels for next generation tissue engineering have also been discussed.

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Facile synthesis of agarose-l-phenylalanine ester hydrogels

Cited by 29 publications

References 37 publications

Preparation and functional evaluation of agarose derivatives

Preparation and functional evaluation of agarose derivatives

Functionalized Agarose Self‐Healing Ionogels Suitable for Supercapacitors

Bioprinting of Thermoresponsive Hydrogels for Next Generation Tissue Engineering: A Review

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