Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug

Hu, Yanchen; Wang, Jing; Zhi, Zhuangzhi; Jiang, Tongying; Wang, Siling

doi:10.1016/j.jcis.2011.07.022

Cited by 132 publications

(61 citation statements)

References 56 publications

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“…Chitosan has structural characteristics similar to glycolsaminoglycans, especially to hyaluronic acid, which is abundant in the extracellular matrix, with the ability to attract proteins, promote cell attachment and enhance implant integration, providing additional and considerable advantage to the implant [24,25]. Indomethacin, a non-steriodal anti-inflammatory drug, was selected for this study as the model of water insoluble drugs [26]. The drug release characteristics of these two systems are explored to demonstrate their potential for the development of TNTs as drug eluting implants with extended drug release characteristics.…”

Section: Introductionmentioning

confidence: 99%

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Aw¹,

Gulati²,

Lošić³

2011

JBNB

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Titania nanotube arrays (TNT) prepared by self-ordering electrochemical anodization have attracted considerable attention for the development of new devices for local drug delivery applications. Two approaches to extend drug release of water insoluble drugs by integrating TNTs with polymeric micelles and biopolymer coatings are presented in this work. The proposed strategies emphasized on remarkable properties of these materials and their unique combination to design local drug delivery system with advanced performance. The first concept integrates TNTs with drug loaded polymeric micelles (Pluronic F127) as drug nanocarrier, until the second concept includes polymer coating of drug loaded TNT with biodegradable polymer (chitosan). The water insoluble, anti-inflammatory drug, indomethacin was used as a model drug. Both approaches showed a significant improvement of the drug release characteristics, withreduced burst release (from 77% to 39%) and extended overall release from 9 days to more than 28 days. These results suggest the capability of TNT based systems to be applied for local drug delivery deliver over an extended period with predictable kinetics that is particularly important for bone implant therapies.

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Section: Introductionmentioning

confidence: 99%

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Aw¹,

Gulati²,

Lošić³

2011

JBNB

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“…Aluminum-tri-sec-butoxide (97%) and Pluronic P123 (EO 20 -PO 70 EO 20 , M w ¼ 5800) were obtained from Sigma-Aldrich Co. Tetrabutylammonium bromide (TBAB), hydrochloric acid (HCl, 37%), and absolute ethanol (99.98%) were purchased from Merck Co. Curcumin was obtained from Exir Nano Sina Co. All the materials were of pro-analysis grade and used without further purication.…”

Section: Materials and Reagentsmentioning

confidence: 99%

“…69 It was supposed that the crystallization of CUR was remarkably hindered and suppressed when constrained into nanoporous alumina. 70 Since XRD pattern of curcumin is crystalline, amorphous XRD of NPA-n@CUR revealed that most of the drug is dispersed inside the pores interacting with the Al-OH groups located in the pore walls. This phenomenon is conrmed by decreasing the pore volume aer loading the drug onto the NPA-n surface.…”

Section: Xrd Analysismentioning

confidence: 99%

“…18 Several synthetic strategies have been reported by different methods such as sol-gel and evaporation-induced selfassembly (EISA) 14,19 relying on different reagents such as (EO) 20 (PO) 70 (EO) 20 triblock copolymer in the presence of additives such as citric or nitric acid, 20 organic acids, 21,22 and (trimethylbenzene) TMB. 19 They can interact with surface hydroxyl groups of alumina via hydrogen bonding that affects the pore size and shape.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis of nanostructured alumina with ultrahigh pore volume for pH-dependent release of curcumin

2017

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In a new approach, a series of nanoporous non-crystalline alumina (NPA) materials was designed and developed by an evaporation-induced self-assembly method in the presence of various weight ) and large pore sizes (up to 23.0 nm). The results indicated that higher pore volume (2.00 cm 3 g À1 ) was obtained when only tetrabutylammonium bromide (namely NPA-100) was used than when only P123 namely NPA-0 (0.5 cm 3 g À1) was used as a template. These new supports were used, for the first time, as an inorganic host for poorly soluble guest of curcumin (CUR). XRD analysis confirmed the amorphous state of CUR after being loaded into the NPAs, which is indicative of the full dispersion of the drug into the pores. The in vitro release behavior of these compounds was studied in simulated gastric fluid (SGF, pH ¼ 1.2) and simulated intestinal fluid (SIF, pH ¼ 6.8). The result indicated that the release of insoluble curcumin reached 80% in SGF when it was supported on alumina with ultrahigh pore volume. Moreover, this carrier showed high drug adsorption. The potential of the NPA-100@CUR in protecting SH-SY5Y cells from oxidative stress by toxin 6-OHDA that caused parkinsonian was tested. The results indicated that the formulation neutralizes 6-OHDA toxicity and significantly enhances cell survival.

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“…IMC ( Figure 1C), a non-steroidal anti-inflammatory drug, was used as a Class II of Biopharmaceutical Classification System (BCS-II) model drug and loaded into all types of nanoporous silica via the solvent deposition method at the same drug-silica ratio. 40,41 Various technical tools, such as scanning electron microscopy (SEM), N 2 adsorption, differential scanning calorimetry (DSC), and X-ray diffraction (XRD) were applied to systematically characterize all IMC-loaded nanoporous silica formulations, aiming to explore the possible mechanism for drug dissolution improvement and the stability of different kinds of silica.…”

mentioning

confidence: 99%

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

Wang¹,

Zhao²,

Hu³

et al. 2013

IJN

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Facile synthesis of 3D cubic mesoporous silica microspheres with a controllable pore size and their application for improved delivery of a water-insoluble drug

Cited by 132 publications

References 56 publications

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Controlling Drug Release from Titania Nanotube Arrays Using Polymer Nanocarriers and Biopolymer Coating

Synthesis of nanostructured alumina with ultrahigh pore volume for pH-dependent release of curcumin

Ordered nanoporous silica as carriers for improved delivery of water insoluble drugs: a comparative study between three dimensional and two dimensional macroporous silica

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