Synthesis of nanostructured alumina with ultrahigh pore volume for pH-dependent release of curcumin

Abstract

In a new approach, a series of nanoporous non-crystalline alumina (NPA) materials was designed and developed by an evaporation-induced self-assembly method in the presence of various weight ) and large pore sizes (up to 23.0 nm). The results indicated that higher pore volume (2.00 cm 3 g À1 ) was obtained when only tetrabutylammonium bromide (namely NPA-100) was used than when only P123 namely NPA-0 (0.5 cm 3 g À1) was used as a template. These new supports were used, for the first time, as an inorganic host for poorly soluble guest of curcumin (CUR). XRD analysis confirmed the amorphous state of CUR after being loaded into the NPAs, which is indicative of the full dispersion of the drug into the pores. The in vitro release behavior of these compounds was studied in simulated gastric fluid (SGF, pH ¼ 1.2) and simulated intestinal fluid (SIF, pH ¼ 6.8). The result indicated that the release of insoluble curcumin reached 80% in SGF when it was supported on alumina with ultrahigh pore volume. Moreover, this carrier showed high drug adsorption. The potential of the NPA-100@CUR in protecting SH-SY5Y cells from oxidative stress by toxin 6-OHDA that caused parkinsonian was tested. The results indicated that the formulation neutralizes 6-OHDA toxicity and significantly enhances cell survival.

Polypyrrole/Carbon Nanotube Freestanding Electrode with Excellent Electrochemical Properties for High-Performance All-Solid-State Supercapacitors

“…Figure S1 presents the FTIR spectrum of curcumin. The absorption bands at 3510 and 2849 cm –1 may be designated as the O–H vibration and C–H stretching vibration of the OCH 3 unit, respectively . The absorption peak at 1628 cm –1 is due to the stretching vibrations of the CO and CC units .…”

“…The absorption bands at 3510 and 2849 cm −1 may be designated as the O−H vibration and C−H stretching vibration of the OCH 3 unit, respectively. 42 The absorption peak at 1628 cm −1 is due to the stretching vibrations of the CO and CC units. 43 The other characteristic absorption peaks at 1510, 1430, 1376, and 1283 cm −1 represent the stretching vibrations of the CO group, 43 olefinic C−H bending vibration, 42 the CH 3 bending vibration, 42 and the aromatic enol C−O stretching, 43 respectively.…”

Cetyltrimethylammonium Bromide (CTAB) Bloated Micelles and Merged CTAB/Bolaamphiphiles Self-Assembled Vesicles toward the Generation of Highly Porous Alumina as Efficacious Inorganic Adsorbents

“…The low-intensity peaks are typically ascribed to the weakly crystalline phase. The formation of the semicrystalline γ-alumina phase is explained by the fact that the complete crystallization temperature of γ-alumina is between 800 and 900 °C while the samples were calcined at 550 °C. , In addition, no obvious peaks are observed for HiPA-CT-8, HiPA-CT-10, and HiPA-CT-12 samples, indicating the amorphous nature of alumina prepared by dicarboxylic acids concomitant with CTAB. It is concluded that the presence of dicarboxylic acid associated with CTAB hinders the crystal growth of γ-alumina due to the interaction of polar head groups of two CTAB molecules with carboxylate groups of dicarboxylic acid molecule and formation of a new template.…”

“…Inorganic porous materials with surprising traits such as large surface area and voluminous pores hold great promise for a new generation of adsorbents. − Nanoporous alumina (NPA) as a subset of porous materials has been used as an adsorbent due to its peculiar physiochemical properties such as surface with rich hydroxyl groups and Lewis acid sites, ability to attach to various compounds with different functional groups on their surface, high surface-to-volume ratio, low toxicity, and ability to be regenerated. ,− Antibiotic molecules usually contain −COOH and −NH groups and −Cl or −F atom as another electrostatic point. They could physically or interactively adsorb onto the surface of alumina .…”

“…Up to now, various methods have been utilized to synthesize porous materials such as template-free approaches and soft and/or hard templating method. , The syntheses based on a soft templating manner mostly rely on evaporation-induced self-assembly (EISA) . In this approach, interaction between surfactant micelles and guest species is crucial to form the mesoporous materials .…”