Facile Synthesis of 1,2,3,4-Tetrahydro-β-Carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization

Abstract

General Methods. IR spectra were determined on a JASCO FT/IR-4100 spectrometer. Exact mass (HRMS) spectra were recorded on JMS-HX/HX 110A mass spectrometer. 1 H NMR spectra were recorded using a JEOL AL-500 spectrometer at 500 MHz frequency. Chemical shifts are reported in δ (ppm) relative to Me 4 Si (in CDCl 3 ) as internal standard. 13 C NMR spectra were recorded using a JEOL AL-500 and referenced