Facile Synthesis and Antibacterial, Antitubercular, and Anticancer Activities of Novel 1,4‐Dihydropyridines

Abstract

A series of twenty new 4-substituted-2,6-dimethyl-3,5-bis-N-(heteroaryl)-carbamoyl-1,4-dihydropyridines have been prepared from a three-component one-pot condensation reaction of N-heteroaryl acetoacetamide, an aromatic/heteroaromatic aldehyde, and ammonium acetate under four different experimental conditions. Except for the conventional method, all the experimental conditions were simple, eco-friendly, economical, and the reactions were rapid and high-yielding. The methods employed have been compared in terms of yields, cost, and simplicity. The synthesized compounds were characterized by different spectroscopic techniques and evaluated for their in-vitro anticancer, antibacterial, and antitubercular activities. Amongst the compounds tested, compound 25 exhibited the highest anticancer activity while compounds 14 and 18 exhibited significant antibacterial and antitubercular activities.

Sulfuric acid heterogenized on magnetic Fe3O4 nanoparticles: A new and efficient magnetically reusable catalyst for condensation reactions

“…[44][45][46] Considering these valuable medicinal applications, we decided to study the catalytic activity of Fe 3 O 4 MNPs-OSO 3 H for the synthesis of Polyhydroquinolines. Initially, to find out optimum reaction conditions and understand the effect of various parameters (such as solvent type, catalyst loading and temperature) on four-component reactions, the reaction of 4-chlorobenzaldehyde (5a), ethyl acetoacetate, dimedone and ammonium acetate was chosen as model reaction.…”

Magnetic Fe3O4 nanoparticles supported imine/Thiophene‐nickel (II) complex: A new and highly active heterogeneous catalyst for the synthesis of polyhydroquinolines and 2, 3‐dihydroquinazoline‐4(1H)‐ones

“…[22][23][24][25][26][27][28][29][30] Polyhydroquinolines also are well-known drugs for the treatment of cardiovascular and Alzheimer's diseases. [31,32] Furthermore, polyhydroquinoline derivatives are well-known as Ca 2+ channel blockers and drugs of NADH co-enzymes. [33,34] The biological and pharmaceutical activities of 2,3-dihydroquinazoline-4(1H)-one and polyhydroquinoline derivatives have encouraged organic chemists to develop numerous one-pot, green strategies for their preparation.…”

Synthesis, Characterization and Docking Studies of Some Novel Dihydropyridine Derivatives

“…Among the many different chemical scaffolds screened, 1,4-dihydropyridine compounds have attracted attention both as antimicrobial agents and MDR-reversing entities because of their ability to exert synergistic antibacterial effects in combination with known antibiotics. [3][4][5][6][7] Their anti-inflammatory. [9] HIV protease inhibition and in the treatment of Alzheimer's disease.…”