Facile strategy by hyaluronic acid functional carbon dot-doxorubicin nanoparticles for CD44 targeted drug delivery and enhanced breast cancer therapy

Li, Jianping; Li, Man; Tian, Lifeng; Qiu, Yue; Yu, Qianwen; Wang, Xuhui; Guo, Rong; He, Qin

doi:10.1016/j.ijpharm.2020.119122

Cited by 107 publications

(51 citation statements)

References 49 publications

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“…Levan’s ability to form nanoparticles is another advantage for developing a DDS of systematic administration. However, if the targeted cancer overexpresses the CD44 receptor, HA is the most proper carrier [ 135 ]; whereas pullulan should be chosen for liver cancer [ 167 ]. Another promising polymer for cancer therapy applications is curdlan since an improvement in a drug’s therapeutic effect when using this EPS has been shown [ 101 ].…”

Section: Eps Selection Rational Design and In Vivo Resultsmentioning

confidence: 99%

“…For example, HA-carbon dot nanoparticles (100 nm) with Doxorubicin (DOX) were prepared using a hydrothermal method. A drug release between 20% and 40%, depending on the pH, was obtained in 50 h, showing a higher internalization and antitumoral activity compared to free DOX [ 135 ]. HA nanoparticles can also self-assemble if the polymer is functionalized properly, as was shown by Wang et al [ 136 ].…”

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

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Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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Microbial exopolysaccharides are peculiar polymers that are produced by living organisms and protect them against environmental factors. These polymers are industrially recovered from the medium culture after performing a fermentative process. These materials are biocompatible and biodegradable, possessing specific and beneficial properties for biomedical drug delivery systems. They can have antitumor activity, they can produce hydrogels with different characteristics due to their molecular structure and functional groups, and they can even produce nanoparticles via a self-assembly phenomenon. This review studies the potential use of exopolysaccharides as carriers for drug delivery systems, covering their versatility and their vast possibilities to produce particles, fibers, scaffolds, hydrogels, and aerogels with different strategies and methodologies. Moreover, the main properties of exopolysaccharides are explained, providing information to achieve an adequate carrier selection depending on the final application.

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Section: Eps Selection Rational Design and In Vivo Resultsmentioning

confidence: 99%

Section: Exopolysaccharides For Producing Ddssmentioning

confidence: 99%

Microbial Exopolysaccharides as Drug Carriers

Cardea

2020

Polymers

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“…An easy approach was developed to synthesize an innovative drug delivery platform for carbon nanoparticles with doxorubicin endowed with HA. The target carbon modified HA (CD-HA) CD44 points were synthesized as a carrier by hydrothermal treatment in one step within an hour with citric acid and branching PEI as a central carbon source [18]. HA not only functioned as a carbon point component but also as a target hydrophilic and ligand group in this system.…”

Section: State-of-the-art Of the Main Treatmentsmentioning

confidence: 99%

“…In addition, hematological and biochemical analysis of blood demonstrated that HA-CD and p-CBA-DOX did not induce noticeable toxicity, which further confirmed the good biocompatibility of HA-CD and p-CBA-DOX. The formulated HA-CD and p-CBA-DOX provide an alternative strategy for therapy directed at breast cancer [18].…”

Section: State-of-the-art Of the Main Treatmentsmentioning

confidence: 99%

State-of-the-Art of the Major Nanopharmaceuticals Treatments in Breast Cancer: A Systematic Review

Gonçalves

Sp²,

Antonio

et al. 2021

MedNEXTJ Med Health Sci

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Introduction: Breast cancer is the most frequently detected cancer in women worldwide, its metastasis is responsible for 90% of deaths. Breast carcinoma is the most common cancer in women worldwide and the most common cause of deaths associated with malignancies. Hyaluronic acid (HA) is the main molecule binding to CD44 and has proved to be a significant ally in the development of nanotransporters that demonstrate preferential accumulation of tumors and increased cellular uptake. Objective: Carry out a systematic review of the main treatments to reduce or prevent the proliferation of breast cancer. Methods: A total of 59 articles have found and after the selection process 20 articles have included and discussed in this study. PUBMED, EMBASE, OVID, AND COCHRANE LIBRARY databases were searched. Results: cationic liposomes containing the conjugate hyaluronic acid-dioleoylphosphatidylethanolamine (HA-DOPE) mediated good transfection in cell lines that express CD44 in culture. Still, other results suggested that the formulation of lapatinib (LPT) coated with HA increases the activity of LPT against triple-negative breast cancer. In addition, compared to free doxorubicin (DOX), superior in vivo antitumor efficacy of modified carbon spots (HA HA-CD) and (p-CBA-DOX) was observed in heterotopic and orthotopic 4T1 cell tumor models. In addition, hematological and biochemical analysis of blood showed that HA-CD and p-CBA-DOX did not induce noticeable toxicity, which further confirmed the good biocompatibility of HA-CD and p-CBA-DOX. Also, it was found that CD44v expression can negatively influence HA uptake and, instead, when cells expressed mainly CD44s, a positive correlation between expression and uptake was observed. Other findings point to the potential clinical utility of recombinant human proteoglycan 4 (rhPRG4) as a therapeutic treatment for invasive and metastatic breast cancer. Conclusion: The development of nanopharmaceuticals delivery systems are able to control the development of tumors and represent a promising strategy to overcome issues related to the non-specific effects of conventional anticancer therapies.

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“…Various polymeric (8), carbon-based (9), and ceramic nanostructures (10) have been studied for this purpose. These structures have specific features including targeted drug delivery (11), high biocompatibility (12), enhancing drug viability in the bloodstream (12), controlling and decelerating the drug release (13), protecting drug molecules (14), having a smaller size than the cells (15), and the ability to cross biological barriers to deliver a drug to the targeted site (16).…”

Section: Introductionmentioning

confidence: 99%

A Mechanistic Insight into Doxorubicin Adsorption on N-isopropyl Acrylamide Grafted Nanotube: Optimization Study of Loading Temperature

Maleki

Dahri

Ghasemy

et al. 2020

Preprint

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Background: The drug development process is costly and time-consuming; hence, nowadays, enormous efforts have been established through computational studies for finding appropriate strategies, methods and solutions for enhancing the drug production and administration procedures. Hydrogels that undertake deformation upon pertinent changes in temperature have significant aptitude as drug delivery systems. These biomaterials have made a substantial impact on the development of drugs for critical diseases, especially cancer therapy. Drug loading and uptake are primary and fundamental steps of the drug development and discovery process. N-isopropyl acrylamide is a common and well-known thermo-sensitive and injectable hydrogel for the drug uptake under the lower critical solution temperature (LCST). In the current study, carbon nanotube (CNT) as a nanocarrier was modified via N-isopropyl acrylamide. On the other hand, Doxorubicin as an anti-cancer drug applied on mentionted systems to develop drug packing at three different temperatures. Results: After computational parametrization of the system via bioinformatics software and databases, Molecular dynamics (MD) simulation was run. To this end, the detailed simulations were carried out to reveal the interaction energy, numbers of hydrogen bonds, the gyration radius, mean square displacement, and radial distribution function as well as Gibss free energy. Besides, the optimal loading temperature for doxorubicin was determined. The results achieved from simulating the polymer demonstrated a decrease in the gyration radius at a higher temperature. A decrease of gyration radius resulted in more concentrated aggregation with stronger bonds.Conclusions: Therefore, at the higher temperature, the more stable polymer interaction and better doxorubicin loading were acquired. The smart absorption of doxorubicin onto the CNT modified via N-iso-propyl acrylamide (NIPA) give a significant and valuable view on the future studies regarding the drug development and novel, biocompatible, and biodegradable stimuli-sensitive drug delivery system.

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Facile strategy by hyaluronic acid functional carbon dot-doxorubicin nanoparticles for CD44 targeted drug delivery and enhanced breast cancer therapy

Cited by 107 publications

References 49 publications

Microbial Exopolysaccharides as Drug Carriers

Microbial Exopolysaccharides as Drug Carriers

State-of-the-Art of the Major Nanopharmaceuticals Treatments in Breast Cancer: A Systematic Review

A Mechanistic Insight into Doxorubicin Adsorption on N-isopropyl Acrylamide Grafted Nanotube: Optimization Study of Loading Temperature

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