Facile scalable one-step wet-spinning of surgical sutures with shape memory function and antibacterial activity for wound healing

Chen, Xinghan; Tan, Pengfei; Wen, Ya; Zhou, Wencheng; Cen, Ying; You, Chao; Tan, Lin; Tian, Meng

doi:10.1016/j.cclet.2019.11.006

Cited by 35 publications

(18 citation statements)

References 23 publications

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“…Braided sutures have a better knotting performance than twisted sutures and monofilament sutures. However, due to the opposite braiding directions of the two yarns and the friction between them, the surface structure of the suture is usually rough and loose . Moreover, the uneven tension of yarns during the braiding process can also make the surface of the suture rough, which can cause a high tissue drag force around the wound when the suture passes through the human tissue during suturing operation.…”

Section: Resultsmentioning

confidence: 99%

“…However, due to the opposite braiding directions of the two yarns and the friction between them, the surface structure of the suture is usually rough and loose. 37 Moreover, the uneven tension of yarns during the braiding process can also make the surface of the suture rough, which can cause a high tissue drag force around the wound when the suture passes through the human tissue during suturing operation. In addition, the presence of gaps on the surface of braided sutures leads to the accumulation and proliferation of bacteria, which is much higher than that of twisted sutures, and this can increase wound infection and prevent the wound from healing.…”

Section: Resultsmentioning

confidence: 99%

“…26 The tensile properties are essential for sutures during surgery operation; 43 In general, braided sutures have better tensile strength and knotting performance than monofilament sutures. 37 Mohammadi et al 28 previously attempted to fabricate antibacterial nylon monofilament sutures using extracted hyaluronic acid and chitosan as components for the bilayer coating technique. However, the coating process led to decreased strength of the coated nylon monofilament, which may not be suitable for the silk suture.…”

Section: Physical and Mechanical Properties Of Suturesmentioning

confidence: 99%

See 2 more Smart Citations

Sustainable Antibacterial Surgical Suture Using a Facile Scalable Silk-Fibroin-Based Berberine Loading System

Wang

et al. 2021

ACS Biomater. Sci. Eng.

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Medical sutures with sustainable antibacterial properties can effectively inhibit pathogens, thus avoiding the occurrence of surgical site infection and reducing the recurrence of patients resulting in postoperative death. This paper describes a facile scalable antibacterial surgical suture with sustainable antibacterial function and fair mechanical and biocompatible properties using a simple, efficient, and eco-friendly method. Silk filaments were braided into a core−shell structure using a braiding machine, and then silk fibroin (SF) films loaded with different percentages of berberine (BB) were coated onto the surface of the suture. The drugloaded sutures performed a slow drug-release profile of more than 7 days. Retention of the knot-pull tensile strength of all groups was above 87% during in vitro degradation within 42 days. The sutures had no toxicity to the cells' in vitro cytotoxicity. The results of the in vivo biocompatibility test showed mild inflammation and clear signs of supporting angiogenesis in the implantation site of the rats. This work provides a new route for achieving a BB-loaded and high-performance antibacterial suture, which is of great potential in applications for surgical operations.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Physical and Mechanical Properties Of Suturesmentioning

confidence: 99%

See 1 more Smart Citation

Sustainable Antibacterial Surgical Suture Using a Facile Scalable Silk-Fibroin-Based Berberine Loading System

Wang

et al. 2021

ACS Biomater. Sci. Eng.

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“…The above way to improve the stability of PHMB in material matrix by weak bonds (e.g., electrostatic attraction, 25 hydrogen bond 26 ) is superior to physical blend to some extent. However, according to our previous work, 27 we realized that the bactericidal performance of these composite materials would gradually decline and could not repel pathogens efficaciously alongside the increasing washing cycles. Thus, in order to improve the washing durability, chemically immobilizing PHMB on the surface of fibers is a research worth exploration 28 …”

Section: Introductionmentioning

confidence: 82%

Polyhexamethylene biguanide hydrochloride anchored polymeric elastic fibers with robust antibacterial performance

Gong

Zhang²,

Luo

et al. 2021

J of Applied Polymer Sci

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Elastic fibers have been widely applied for the fabrication of biomedical textiles, artificial extracellular matrix, and functional garments, as where antibacterial property is one of the indispensable features. Herein, we developed a fresh type of non‐leaching antibacterial fiber that could effectively inactivate bacteria with durable performance to circumvent above concerns. In detail, we firstly synthesized a precursor polymer (PS‐GMA) based on styrene and glycidyl methacrylate (GMA) through free radical polymerization, then blended PS‐GMA with thermoplastic polyurethane (TPU) and processed the blend into fiber through wet spinning technology. Finally, the obtained fiber was covalently modified by polyhexamethylene biguanide hydrochloride (PHMB). The experimental results showed that the resultant fiber (named as PGPs) exhibited a strong bactericidal ability to both Staphylococcus aureus and Escherichia coli, as well as maintained excellent antibacterial properties even after ultraviolet irradiation for 7 days or 50 washing cycles. Furthermore, we explored the sterilization mechanism with respect to the bacterial morphologies and the activity of the respiratory chain dehydrogenase. In addition, the biocidal efficacy of the prepared fiber could remain approximately 100% after eight consecutive antibacterial cycles. Collectively, this work exhibited an attempt in exploitation of the intrinsically antibacterial fiber with long‐run function duration by an economical tactic.

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“…For this reason, feasible drugs for diabetic patients' rapid wound healing should be developed. Traditional medicines have always achieved an application for medicine and have attracted wide attention because of their ability of expediting wound healing with no serious side effect [ 9 , 10 ]. The mentioned herbs can refer to subsequent medicine to heal wounds [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of the Chinese Herb Medicine Formula “She-Xiang-Yu-Hong” Ointment on Wound Healing Promotion in Diabetic Mice

Liu

Shi-hui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Wound healing in diabetic patients is a difficult problem to be solved at present. In addition, patients with diabetes have an increased risk of postoperative wound complications. “She-Xiang-Yu-Hong” (SXYH) ointment is a type of traditional Chinese medicine (TCM) compound used to treat wounds. Over the past few years, SXYH has been applied in the Affiliated Hospital of Chengdu University of TCM (Chengdu, China) for the treatment of diabetic foot infections and bedsores, whereas there has been rare research on the effect of SXYH ointment on wound healing. In this study, SXYH ointment was first applied to streptozotocin (STZ)-triggered diabetic ICR mice (4–6 weeks, 20 ± 2 g) to observe the accelerated wound healing and the shortened wound healing period. As indicated by the histology and biochemistry analyses of skin biopsies, the wounds treated using SXYH ointment showed an increase in the granulation tissue. Moreover, SXYH also modulated the inflammation response by regulating affinity proinflammatory cytokines release (e.g., IL-6 and TNF-α). Furthermore, SXYH ointment obviously improved collagen fiber deposition and tissue on the wound surface. On the whole, this study indicated that SXYH ointment could accelerate wound healing, promote blood vessel formation, and suppress inflammations. Thus, the clinical potential of SXYH ointment was demonstrated in the treatment of diabetes and refractory wounds.

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Facile scalable one-step wet-spinning of surgical sutures with shape memory function and antibacterial activity for wound healing

Cited by 35 publications

References 23 publications

Sustainable Antibacterial Surgical Suture Using a Facile Scalable Silk-Fibroin-Based Berberine Loading System

Sustainable Antibacterial Surgical Suture Using a Facile Scalable Silk-Fibroin-Based Berberine Loading System

Polyhexamethylene biguanide hydrochloride anchored polymeric elastic fibers with robust antibacterial performance

Effects of the Chinese Herb Medicine Formula “She-Xiang-Yu-Hong” Ointment on Wound Healing Promotion in Diabetic Mice

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