Polyhexamethylene biguanide hydrochloride anchored polymeric elastic fibers with robust antibacterial performance

Abstract

Elastic fibers have been widely applied for the fabrication of biomedical textiles, artificial extracellular matrix, and functional garments, as where antibacterial property is one of the indispensable features. Herein, we developed a fresh type of non‐leaching antibacterial fiber that could effectively inactivate bacteria with durable performance to circumvent above concerns. In detail, we firstly synthesized a precursor polymer (PS‐GMA) based on styrene and glycidyl methacrylate (GMA) through free radical polymerization, then blended PS‐GMA with thermoplastic polyurethane (TPU) and processed the blend into fiber through wet spinning technology. Finally, the obtained fiber was covalently modified by polyhexamethylene biguanide hydrochloride (PHMB). The experimental results showed that the resultant fiber (named as PGPs) exhibited a strong bactericidal ability to both Staphylococcus aureus and Escherichia coli, as well as maintained excellent antibacterial properties even after ultraviolet irradiation for 7 days or 50 washing cycles. Furthermore, we explored the sterilization mechanism with respect to the bacterial morphologies and the activity of the respiratory chain dehydrogenase. In addition, the biocidal efficacy of the prepared fiber could remain approximately 100% after eight consecutive antibacterial cycles. Collectively, this work exhibited an attempt in exploitation of the intrinsically antibacterial fiber with long‐run function duration by an economical tactic.

Poly(hexamethylene biguanide) hydrochloride (PHMB)-based materials: synthesis, modification, properties, determination, and application

“…They also reported a PHMB-modified elastic fibre with robust antibacterial activity. 124 The polymeric elastic fibres were initially fabricated by a wet spinning technology through blending as-synthesized styrene and glycidyl methacrylate copolymer and thermoplastic polyurethane. Subsequently, PHMB was immobilized on the fibre via chemical modification.…”

Nonleaching Antimicrobial Cotton Fabrics Finished with Hyperbranched Polylysine

“…Nonleaching antimicrobial fabrics are constructed by chemically bonding antimicrobial agents on the fabric surfaces and kill the microbes by destroying the integrity of the cell membrane through electrostatic interaction. , Chemical bonding inhibits the dissolution of the antimicrobial agent, greatly improving the safety and washing durability of nonleaching antimicrobial fabrics. − There is only one kind of commercial silicone quaternary ammonium salt antimicrobial agents that can be obtained in the market . Various new finishing strategies and antimicrobial agents have been designed and developed to overcome this limitation. − Chen et al synthesized a series of reactive antimicrobial finishing agent, siloxane sulfopropylbetaine (SSPB), zwitterionic sulfopropylbetaine (NCO-sulfopropylbetaine), and isocyanate group (NCO)-containing quaternary ammonium salt (IQAS), to prepare various durable antimicrobial CF surfaces. Liu et al utilized the mist polymerization method via initiating a functional monomer, methacryloxyethyltrimethylammonium chloride (DMC), to copolymerize with acrylic acid pretreated on the surface of the CF, to prepare the Janus CF with excellent antibacterial and antifouling performances .…”