Facile Preparation of Polylactic Acid/Ketoconazole Composite Microspheres by Oil/Water Solvent Evaporation Method

Abstract

In this study, polylactic acid(PLA)/ketoconazole(KCZ) composite microspheres were prepared by oil/water solvent evaporation method. Those drug-loaded microspheres were characterized in morphology using the scanning electron microscope (SEM). Fourier transform infrared spectroscopy (FT-IR) was used to determine the chemical functional groups in the sample and to analysis whether a chemical reaction occured between PLA and KCZ. The thermogravimetric spectra of PLA and PLA/KCZ microspheres were used to analyse the influence of KCZ on the thermal decomposition mechanism of PLA. Crystallinities of the KCZ and PLA/KCZ were analyzed by X-ray diffraction analysis (XRD).

Development and in vitro characterization of drug delivery system of rifapentine for osteoarticular tuberculosis

“…Since rifapentine is a hydrophobic compound, RPMs were prepared by oil-in-water (O/W) emulsion solvent evaporation method. 13 Briefly, 200 mg of PLGA was dissolved in 10 mL dichloromethane (DCM), and different amounts of rifapentine (0, 20, 50, 100 mg, named RPMs0, RPMs20, RPMs50, and RPMs100) were dissolved into the polymer solution. The polymer–solvent–drug solution (dispersed phase) was uniformly injected into 100 mL of 2 wt% PVA 1799 aqueous solution (continuous phase).…”