Facile preparation of ammonium alginate-derived nanofibers carrying diverse therapeutic cargo

Pegg, Caitlin; Jones, Gregory H.; Athauda, Thushara J.; Ozer, Ruya R.; Chalker, Justin M.

doi:10.1039/c3cc47232a

Cited by 24 publications

(19 citation statements)

References 31 publications

(2 reference statements)

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“…26 Recent literature has reported the carbon nanoparticles obtained from sodium alginate via ultrasonic-assisted nanoprecipitation and thermal acid dehydration, but the complicated synthesis processes, large nanoparticle sizes and low QYs without investigation at low pH values have limited their practical use. It has been in widespread use in water treatment, food additives, and biomedical materials.…”

Section: Synthetic Strategymentioning

confidence: 99%

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe³⁺ detection

et al. 2015

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Robust and highly fluorescent N-doped carbon dots (CDs) are obtained from a hybrid source, alginic acid and ethanediamine. During a hydrothermal process, the raw materials are propelled to form nano-size particles; these resultant CDs possess desirable functional groups on the particle surface. We have further investigated their optical performance under various pH conditions as well as their capacity for sensing metal ions. The N-doped CDs especially exhibit remarkable acid-evoked fluorescence enhancement under acidic conditions. Finally, the as-prepared CDs are tested for their ability to detect of Fe 3+ in acidic pure water and urban river water media, the fluorescence-quenching mechanism and recovery properties of the CDs/Fe 3+ mixture are also investigated.

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Section: Synthetic Strategymentioning

confidence: 99%

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe³⁺ detection

et al. 2015

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“…Similar studies reported that ionic interactions between bulk of carbohydrate polymers and small molecules improve drug affinity and long‐term release. In this regard, hyaluronic acid and alginate carriers have been applied. We showed that surface modification of PHEMA polymers using a highly charged polysaccharide like chitosan could improve ascorbic acid loading (most presumably though ionic interactions between opposite charges) and increase sustained release up to 10 days.…”

Section: Discussionmentioning

confidence: 99%

Chitosan surface modified hydrogel as a therapeutic contact lens

Ashtiani

Zandi

Shokrollahi

et al. 2019

Polymers for Advanced Techs

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Therapeutic contact lenses have attracted significant attention during the last decades. In this study, we used chitosan‐conjugated poly(2‐hydroxyethyl methacrylate) (PHEMA) for contact lens application. We aimed to increase affinity of anionic drugs, which are used in treatment of eye diseases. In this regard, we evaluated delivery of the small molecule anionic drug, ascorbic acid from the chitosan‐conjugated PHEMA. Chitosan immobilization improves drug loading efficiency and induces sustained release of ascorbic acid. The chitosan modified hydrogel also reduces the biofouling of tear fluid components. Our results showed that surface modification by chitosan inhibits protein and bacterial deposition on the contact lens. Protein absorption analysis revealed that neat PHEMA adsorbed tear proteins at a density of 28.4 ± 4.4 μg/cm2, whereas the chitosan‐conjugated hydrogel adsorbed tear proteins at a density of 18.5 ± 1.8 μg/cm2. Moreover, the neat PHEMA bacterial adhesion had a mean CFU value of 273 ± 27. However, a significant decrease in the number of bacterial colonies was observed in the chitosan group with a CFU value of 9 ± 6.

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“…The usage of other natural polymers to form a polyelectrolyte complex toward biomedical applications has also been reported in the literature [48][49][50]. The polyelectrolyte complex made up of chitosan and alginate was prepared by employing a co-axial electrospinning technique [48].…”

Section: Advanced Electrospinning Techniquesmentioning

confidence: 99%

Electrospun Alginate Nanofibers Toward Various Applications: A Review

et al. 2020

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Alginate has been a material of choice for a spectrum of applications, ranging from metal adsorption to wound dressing. Electrospinning has added a new dimension to polymeric materials, including alginate, which can be processed to their nanosize levels in order to afford unique nanostructured materials with fascinating properties. The resulting nanostructured materials often feature high porosity, stability, permeability, and a large surface-to-volume ratio. In the present review, recent trends on electrospun alginate nanofibers from over the past 10 years toward advanced applications are discussed. The application of electrospun alginate nanofibers in various fields such as bioremediation, scaffolds for skin tissue engineering, drug delivery, and sensors are also elucidated.

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Facile preparation of ammonium alginate-derived nanofibers carrying diverse therapeutic cargo

Cited by 24 publications

References 31 publications

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe³⁺ detection

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe³⁺ detection

Chitosan surface modified hydrogel as a therapeutic contact lens

Electrospun Alginate Nanofibers Toward Various Applications: A Review

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Facile preparation of ammonium alginate-derived nanofibers carrying diverse therapeutic cargo

Cited by 24 publications

References 31 publications

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe3+ detection

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe3+ detection

Chitosan surface modified hydrogel as a therapeutic contact lens

Electrospun Alginate Nanofibers Toward Various Applications: A Review

Contact Info

Product

Resources

About

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe³⁺ detection

One-step synthesis of robust nitrogen-doped carbon dots: acid-evoked fluorescence enhancement and their application in Fe³⁺ detection