Facile preparation of 177Lu-microspheres for hepatocellular carcinoma radioisotope therapy

Wu, Manran; Shi, Kexing; Huang, Ran; Liu, Chunyi; Yin, Lei; Yong, Wei‐Peng; Sun, Jing; Wang, Guanglin; Zhong, Zhiyuan; Gao, Mingyuan

doi:10.1016/j.cclet.2022.01.007

Cited by 8 publications

(19 citation statements)

References 37 publications

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“…Comparing Figure 6 and Figure 7 , it is clear that the cytotoxic effect through the chemical generation of ROS is negligible compared to the radiotoxic effect presented in Figure 7 . The presented results are consistent with the results published by Wu et al [ 39 ] investigating the effect of the other β − emitter, 177 Lu on HepG2 cells. As in our studies, for 1.85 MBq activity of free 177 Lu, cell survival after 24 h was ~85%.…”

Section: Resultssupporting

confidence: 93%

198Au-Coated Superparamagnetic Iron Oxide Nanoparticles for Dual Magnetic Hyperthermia and Radionuclide Therapy of Hepatocellular Carcinoma

Gharibkandi

Żuk

Müftüler

et al. 2023

IJMS

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This study was performed to synthesize a radiopharmaceutical designed for multimodal hepatocellular carcinoma (HCC) treatment involving radionuclide therapy and magnetic hyperthermia. To achieve this goal, the superparamagnetic iron oxide (magnetite) nanoparticles (SPIONs) were covered with a layer of radioactive gold (198Au) creating core–shell nanoparticles (SPION@Au). The synthesized SPION@Au nanoparticles exhibited superparamagnetic properties with a saturation magnetization of 50 emu/g, which is lower than reported for uncoated SPIONs (83 emu/g). Nevertheless, the SPION@Au core–shell nanoparticles showed a sufficiently high saturation magnetization value which allows them to reach a temperature of 43 °C at a magnetic field frequency of 386 kHz. The cytotoxic effect of nonradioactive and radioactive SPION@Au–polyethylene glycol (PEG) bioconjugates was carried out by treating HepG2 cells with various concentrations (1.25–100.00 µg/mL) of the compound and radioactivity in range of 1.25–20 MBq/mL. The moderate cytotoxic effect of nonradioactive SPION@Au-PEG bioconjugates on HepG2 was observed. The cytotoxic effect associated with the β− radiation emitted by 198Au was much greater and already reaches a cell survival fraction below 8% for 2.5 MBq/mL of radioactivity after 72 h. Thus, the killing of HepG2 cells in HCC therapy should be possible due to the combination of the heat-generating properties of the SPION-198Au–PEG conjugates and the radiotoxicity of the radiation emitted by 198Au.

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Section: Resultssupporting

confidence: 93%

198Au-Coated Superparamagnetic Iron Oxide Nanoparticles for Dual Magnetic Hyperthermia and Radionuclide Therapy of Hepatocellular Carcinoma

Gharibkandi

Żuk

Müftüler

et al. 2023

IJMS

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“…177 Lu-MS with high radiolabeling efficiency (97.8 ± 1.2%) were obtained through a facile precipitating method, as previously reported …”

Section: Resultsmentioning

confidence: 99%

“…However, 177 Lu is being considered as an attractive alternative due to its favorable physicochemical properties and good commercial availability. 177 Lu emits beta particles (498 keV) and low-energy gamma photons (210 keV (11%), 113 keV (6%)), which can be used for therapy and imaging, respectively. , Thus, 177 Lu becomes a suitable choice for TARE application; however, it requires a reliable radiolabeling technique to avoid unnecessary side effects of the leached radioisotopes to normal tissues. , To date, there have been a few studies reported on radioactive microspheres, which remained to be improved with respect to radiostability. − …”

Section: Introductionmentioning

confidence: 99%

“…177 Preparation and Characterization of 177 Lu-MS@PDA. The 177 Lu-labeled silica microspheres (MS) were prepared according to a previous report 24 and denoted as 177 Lu-MS. Briefly, 177 LuCl 3 solution (5 μL, 100 μCi) was added into 0.5 mL of H 2 O containing 10 mg of silica MS. After 2 min under shaking at 25 °C, 100 μL of aqueous solution of K 3 PO 4 (1 M) was introduced into the above solution.…”

Section: ■ Introductionmentioning

confidence: 99%

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Polydopamine-Coated Radiolabeled Microspheres for Combinatorial Radioembolization and Photothermal Cancer Therapy

Zhang

Shi

et al. 2023

ACS Appl. Mater. Interfaces

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Transarterial radioembolization (TARE) is a local radionuclide therapy and is successfully used in hepatocellular carcinoma (HCC) treatment. Radioactive microspheres have been widely studied for TARE. Preparation of ideal radioactive microspheres is significant for clinical research and patient treatment. In this study, we have designed a novel multifunctional microsphere, i.e., polydopamine (PDA)-coated 177Lu-radiolabeled silica microspheres (MS) denoted as 177Lu-MS@PDA, which can be used for TARE and photothermal therapy (PTT). The radiostability of 177Lu-MS@PDA was significantly improved by coating 177Lu-MS with PDA. In addition, the coating of PDA makes microspheres have excellent photothermal performance. MicroSPECT/CT images showed that 177Lu-MS@PDA was accurately embolized and remained in the tumor during the observation time. At the time, it also showed that 177Lu-MS@PDA was very stable in vivo. Furthermore, the anti-tumor results demonstrated that TARE combined with PTT of 177Lu-MS@PDA can significantly inhibit tumor growth without obvious side effects. 177Lu-MS@PDA holds great potential as a promising radioactive microsphere for HCC.

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“…Additionally, because the half-life of 188 Re is as short as 16.9 h, it cannot be transported and stored for a long time. Furthermore, the injection activity of 188 Re must also be around 2.8 times higher than that of 90 Y to reach an equivalent treatment effect, which exposes physicians and patients to more radiation [81]. Currently, preliminary results of the phase 1 188 Re-lipiodol I clinical trial have clearly shown that 188 Re-lipiodol displays remarkable biodistribution characteristics and tumor targeting, as well as the highest in-vivo stability among all radiolabeled Lipiodol compounds reported to date [82].…”

Section: Rhenium-188 ( 188 Re)mentioning

confidence: 99%

Smart nanoparticles and microbeads for interventional embolization therapy of liver cancer: state of the art

Fan

Yang

et al. 2023

J Nanobiotechnol

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The process of transcatheter arterial chemoembolization is characterized by the ability to accurately deliver chemotherapy drugs with minimal systemic side effects and has become the standard treatment for unresectable intermediate hepatocellular carcinoma (HCC). However, this treatment option still has much room for improvement, one of which may be the introduction of nanomaterials, which exhibit unique functions and can be applied to in vivo tumor imaging and therapy. Several biodegradable and multifunctional nanomaterials and nanobeads have recently been developed and applied in the locoregional treatment of hepatocellular cancer. This review explores recent developments and findings in relation to micro-nano medicines in transarterial therapy for HCC, emerging strategies to improve the efficacy of delivering nano-based medicines, and expounding prospects for clinical applications of nanomaterials.

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Facile preparation of 177Lu-microspheres for hepatocellular carcinoma radioisotope therapy

Cited by 8 publications

References 37 publications

198Au-Coated Superparamagnetic Iron Oxide Nanoparticles for Dual Magnetic Hyperthermia and Radionuclide Therapy of Hepatocellular Carcinoma

198Au-Coated Superparamagnetic Iron Oxide Nanoparticles for Dual Magnetic Hyperthermia and Radionuclide Therapy of Hepatocellular Carcinoma

Polydopamine-Coated Radiolabeled Microspheres for Combinatorial Radioembolization and Photothermal Cancer Therapy

Smart nanoparticles and microbeads for interventional embolization therapy of liver cancer: state of the art

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