Facile one-pot synthesis of self-assembled nitrogen-doped carbon dots/cellulose nanofibril hydrogel with enhanced fluorescence and mechanical properties

Chen, Xueqi; Song, Zihui; Li, Shaopeng; Nguyen, Tat Thang; Gao, Xing; Gong, Xinchao; Guo, Minghui

doi:10.1039/d0gc00845a

Cited by 60 publications

(35 citation statements)

References 61 publications

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“…It was found that the presence of CMCs can appreciably improve the physical properties of PF127 hydrogel, which makes it more suitable for tailored drug loading [ 19 ]. However, efforts have been taken to produce more sustainable and green hydrogels, such as using cellulose extracted from agricultural biomass [ 22 ], engineered hydrogels based on sustainable cellulose acetate [ 23 ], as well as manufacturing of cellulose/alginate monolithic hydrogel for environmental applications [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Al-Rajabi

Teow

2021

Polymers

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Drug delivery is a difficult task in the field of dermal therapeutics, particularly in the treatment of burns, wounds, and skin diseases. Conventional drug delivery mediums have some limitations, including poor retention on skin/wound, inconvenience in administration, and uncontrolled drug release profile. Hydrogels able to absorb large amount of water and give a spontaneous response to stimuli imposed on them are an attractive solution to overcome the limitations of conventional drug delivery media. The objective of this study is to explore a green synthesis method for the development of thermo-responsive cellulose hydrogel using cellulose extracted from oil palm empty fruit bunches (OPEFB). A cold method was employed to prepare thermo-responsive cellulose hydrogels by incorporating OPEFB-extracted cellulose and Pluronic F127 (PF127) polymer. The performance of the synthesized thermo-responsive cellulose hydrogels were evaluated in terms of their swelling ratio, percentage of degradation, and in-vitro silver sulfadiazine (SSD) drug release. H8 thermo-responsive cellulose hydrogel with 20 w/v% PF127 and 3 w/v% OPEFB extracted cellulose content was the best formulation, given its high storage modulus and complex viscosity (81 kPa and 9.6 kPa.s, respectively), high swelling ratio (4.22 ± 0.70), and low degradation rate (31.3 ± 5.9%), in addition to high t50% value of 24 h in SSD in-vitro drug release to accomplish sustained drug release. The exploration of thermo-responsive cellulose hydrogel from OPEFB would promote cost-effective and sustainable drug delivery system with using abundantly available agricultural biomass.

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Section: Introductionmentioning

confidence: 99%

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Al-Rajabi

Teow

2021

Polymers

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“…In SPI/ESO10/GQD0.6 spectra, amide I and amide II moved from 1645 and 1548 cm −1 to 1653 and 1553 cm −1 , indicating that GQD had reacted by hydrogen bond with SPI/ESO. [ 30,31 ]…”

Section: Resultsmentioning

confidence: 99%

Spider Silk Inspired Robust and Photoluminescent Soybean‐Protein‐Based Materials

Zhou

Dong

et al. 2021

Macro Materials & Eng

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Development of mechanical robust and functional biomass‐based materials still remains challenging. Here, a design strategy inspired by spider silk structure is proposed to prepare strong, robust, and photoluminescent soybean protein isolate (SPI)‐based materials, by integrating epoxy soybean oil (ESO) and SPI as soft phase matrices and graphene oxide quantum dots (GQDs) as hard phase. The results show that the soft–hard coordination network can form a close covalent/hydrogen bond network. The tensile strength, elongation at break, and toughness of the SPI/ESO/GQD film are 13.22 MPa, 209%, and 22.54 MJ m−3, respectively. In addition, SPI/ESO/GQD has strong photoluminescence intensity due to the ring‐opening polymerization of amino structure with epoxy resin. The prepared SPI‐based materials are promising candidates for optical coatings and provide new ideas for the intelligent research of other protein‐based materials.

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“…Designing scaffolds with suitable mechanical properties is an essential criterion in tissue engineering applications as the cell adhesion, proliferation, and differentiation are highly dependent on the mechanical property of the scaffold [ 25 , 102 ]. Scientific studies have reported that the scaffold materials, including fiber, film, and hydrogel, exhibited substantially increased mechanical properties due to the presence of CDs [ 103 , 104 , 105 , 106 , 107 ]. For example, Ghorghi et al revealed that the incorporation of CQDs into the polycaprolactone- captopril (PCL-CP) scaffold led to an enhanced tensile strength (22.09 ± 0.06 MPa) and Young’s modulus (2.83 ± 0.23 MPa) than that of pure PCL scaffold (tensile strength 6.86 MPa and Young’s modulus 0.15 MPa).…”

Section: Properties Of Carbon Dotsmentioning

confidence: 99%

Carbon Dots-Mediated Fluorescent Scaffolds: Recent Trends in Image-Guided Tissue Engineering Applications

Vedhanayagam

Raja

Molkenova

et al. 2021

IJMS

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Regeneration of damaged tissues or organs is one of the significant challenges in tissue engineering and regenerative medicine. Many researchers have fabricated various scaffolds to accelerate the tissue regeneration process. However, most of the scaffolds are limited in clinical trials due to scaffold inconsistency, non-biodegradability, and lack of non-invasive techniques to monitor tissue regeneration after implantation. Recently, carbon dots (CDs) mediated fluorescent scaffolds are widely explored for the application of image-guided tissue engineering due to their controlled architecture, light-emitting ability, higher chemical and photostability, excellent biocompatibility, and biodegradability. In this review, we provide an overview of the recent advancement of CDs in terms of their different synthesis methods, tunable physicochemical, mechanical, and optical properties, and their application in tissue engineering. Finally, this review concludes the further research directions that can be explored to apply CDs in tissue engineering.

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Facile one-pot synthesis of self-assembled nitrogen-doped carbon dots/cellulose nanofibril hydrogel with enhanced fluorescence and mechanical properties

Abstract: A facile one-pot method is used to synthesize and self-assemble nanofibril cellulose hydrogels with carbon dots as intensity enhancement and fluorescent emission factors.

Cited by 60 publications

References 61 publications

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Green Synthesis of Thermo-Responsive Hydrogel from Oil Palm Empty Fruit Bunches Cellulose for Sustained Drug Delivery

Spider Silk Inspired Robust and Photoluminescent Soybean‐Protein‐Based Materials

Carbon Dots-Mediated Fluorescent Scaffolds: Recent Trends in Image-Guided Tissue Engineering Applications

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