Facile one-pot synthesis of magnetic nitrogen-doped porous carbon for high-performance bilirubin removal from BSA-rich solution

Abstract

The development of high-performance adsorbents for efficient removal of bilirubin from albumin-rich solution is still a considerable challenge. In this study, a magnetic nitrogen-doped porous carbon (mNpC) was facilely synthesized through a simple one-pot route using the biomass chitosan and the iron salt Fe(NO 3 ) 3 $9H 2 O as precursors, and NaCl as template agent, respectively. Intriguingly, the resulting mNpC material showed a hierarchically micro-meso-macroporous structure, high surface area (289 m ), but also superior to those of many previously reported adsorbents for BSA-boned bilirubin removal. Moreover, as evidenced by hemolysis assay, this material exhibited only a negligible hemolysis effect. These results suggest that the composite developed in this work can be used as a promising adsorbent in blood purification application to mitigate the risk of excess bilirubin.

Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption

“…5,57 The addition of CS improved the mechanical properties of the rGO/CS20 and ensured high adsorption capacity than those of previously reported adsorbents in the literature. 1,10,[58][59][60] The photos of rGO/CSn before and aer reduced by sodium ascorbate were shown in Fig. 9(d).…”

“…62,63 Also it could be concluded that the rGO/CSn materials had a heterogeneous surface in accordance to the theoretical assumption of Freundlich model. 1 3.6.3 Bilirubin adsorption in the presence of BSA. In blood, bilirubin strongly tends to form a complex with albumin.…”

Soft-template solvent thermal method synthesis of magnetic mesoporous carbon–silica composite for adsorption of methyl orange from aqueous solution

“…Yuso et al synthesized MMC via a one-pot microwave-assisted self-assembly strategy which allowed the formation of mesoporous carbon and the growth of the particles at the same time (Yuso et al, 2016). Ma et al reported a simple one-pot route to synthesize MMC using the biomass chitosan and Fe(NO 3 ) 3 •9H 2 O as precursors and NaCl as template agent (Ma et al, 2017). In particular, one-pot method combined with surfactant-assisted soft template can greatly simplify the synthesis of MMC and reduce the cost, which has been applied in the preparation of magnetic mesoporous carbon intensively (Zhang et al, 2016).…”

Soft-Template Solvent Thermal Method Synthesis of Magnetic Mesoporous Carbon-Silica Composite For Adsorption of Methyl Orange From Aqueous Solution

“…As a consequence, it is crucial to develop a facile strategy to eliminate the complex fabricating process, such as forming mesoporous carbonaceous matrix with simultaneously generating magnetic nanoparticles in situ in one pot. Yuso et al synthesized MMC via a one-pot microwave-assisted self-assembly strategy which allowed the formation of mesoporous carbon and the growth of the particles at the same time (Yuso et al, 2016 (Ma et al, 2017). In particular, one-pot method combined with surfactant-assisted soft template can greatly simplify the synthesis of MMC and reduce the cost, which has been applied in the preparation of magnetic mesoporous carbon intensively (Zhang et al, 2016).…”