Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption

Li, Zhentao; Song, Xingguo; Cui, Siyuan; Jiao, Yanpeng; Zhou, Changren

doi:10.1039/c8ra00358k

Cited by 45 publications

(19 citation statements)

References 66 publications

(93 reference statements)

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“…Activated partial thromboplastin time (aPTT) and prothrombin time (PT) were used to characterize the influence of CDDs‐TBA on the intrinsic coagulation pathway and extrinsic coagulation pathway, respectively. [ 31 ] The results showed that the aPTT values were significantly reduced by 2%CDDs‐30%TBA (21.16 ± 0.99%), followed by 2%CDDs‐60%TBA (27.60 ± 1.07%), 2%CDDs (29.77 ± 1.61%), and 2%CDDs‐100%TBA (30.93 ± 0.99%) compared with that of control group (Figure 4C). Silanol group has very strong polar interactivity, [ 32 ] which exists on the surface of DB in CDDs‐TBA.…”

Section: Resultsmentioning

confidence: 96%

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Sun

Zhang

et al. 2020

Adv Healthcare Materials

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Uncontrolled hemorrhage is the main reason of possible preventable death after accidental injury. It is necessary to develop a hemostatic agent with rapid hemostatic performance and good biocompatibility. In this study, a chitosan/diatom-biosilica-based aerogel is developed using dopamine as cross-linker by simple alkaline precipitation and tert-butyl alcohol replacement. The chitosan/diatom-biosilica aerogel exhibits favorable biocompatibility and multiscale hierarchical porous structure (from nanometer to micrometer), which can be controlled by the concentration of tert-butyl alcohol. The displacement of tert-butyl alcohol can keep the porosity of diatom-biosilica in aerogel and give it large surface with efficient water absorption ratio. 30% tert-butyl alcohol replacement of aerogel possesses the largest surface area (74.441 m 2 g −1), water absorption capacity (316.83 ± 2.04%), and excellent hemostatic performance in vitro blood coagulation (≈70 s). Furthermore, this aerogel exhibits the shortest clotting time and lowest blood loss in rat hemorrhage model. The strong interface effect between aerogel and blood is able to promote erythrocytes aggregation, platelets adhesion, and activation, as well as, activate the intrinsic coagulation pathway to accelerate blood coagulation. All the above results demonstrate that chitosan/diatom-biosilica aerogel has great potential to be a safe and rapid hemostatic material.

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Section: Resultsmentioning

confidence: 96%

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Sun

Zhang

et al. 2020

Adv Healthcare Materials

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“…The other peaks at 285.40, 286.58, and 288.84 eV are ascribed to the functional groups of C–N, C–O, and O–C=O, respectively. The arisen functional group of C–N may be due to the attachment of the GC chains [ 45 ]. Finally, Figure 4 h presents high-resolution XPS C 1s spectra of rGO-PGA.…”

Section: Resultsmentioning

confidence: 99%

Graphene Oxide and Reduced Graphene Oxide Nanoflakes Coated with Glycol Chitosan, Propylene Glycol Alginate, and Polydopamine: Characterization and Cytotoxicity in Human Chondrocytes

et al. 2021

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Recently, graphene and its derivatives have been extensively investigated for their interesting properties in many biomedical fields, including tissue engineering and regenerative medicine. Nonetheless, graphene oxide (GO) and reduced GO (rGO) are still under investigation for improving their dispersibility in aqueous solutions and their safety in different cell types. This work explores the interaction of GO and rGO with different polymeric dispersants, such as glycol chitosan (GC), propylene glycol alginate (PGA), and polydopamine (PDA), and their effects on human chondrocytes. GO was synthesized using Hummer’s method, followed by a sonication-assisted liquid-phase exfoliation (LPE) process, drying, and thermal reduction to obtain rGO. The flakes of GO and rGO exhibited an average lateral size of 8.8 ± 4.6 and 18.3 ± 8.5 µm, respectively. Their dispersibility and colloidal stability were investigated in the presence of the polymeric surfactants, resulting in an improvement in the suspension stability in terms of average size and polydispersity index over 1 h, in particular for PDA. Furthermore, cytotoxic effects induced by coated and uncoated GO and rGO on human chondrocytes at different concentrations (12.5, 25, 50 and 100 µg/mL) were assessed through LDH assay. Results showed a concentration-dependent response, and the presence of PGA contributed to statistically decreasing the difference in the LDH activity with respect to the control. These results open the way to a potentially safer use of these nanomaterials in the fields of cartilage tissue engineering and regenerative medicine.

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“…The results showed that the composite cryogel had a high adsorption capacity (458.9 mg/g) and a fast adsorption rate. In addition, the composite cryogel also had a low hemolysis ratio and negligible anti-coagulant activity that could suggest good compatibility and high capacity adsorption, making it a potential candidate for blood samples [57].…”

Section: Composite Cryogels As Versatile Tools For Biomedical Applmentioning

confidence: 99%

Supermacroporous Composite Cryogels in Biomedical Applications

Saylan

Denizli

2019

Gels

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Supermacroporous gels, called cryogels, are unique scaffolds that can be prepared by polymerization of monomer solution under sub-zero temperatures. They are widely used in many applications and have significant potential biomaterials, especially for biomedical applications due to their inherent interconnected supermacroporous structures and easy formation of composite polymers in comparison to other porous polymer synthesis techniques. This review highlights the fundamentals of supermacroporous cryogels and composite cryogels, and then comprehensively summarizes recent studies in preparation, functionalization, and utilization with mechanical, biological and physicochemical features, according to the biomedical applications. Furthermore, conclusions and outlooks are discussed for the use of these promising and durable supermacroporous composite cryogels.

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Fabrication of macroporous reduced graphene oxide composite aerogels reinforced with chitosan for high bilirubin adsorption

Abstract: Chitosan reinforced macroporous reduced graphene oxide composite aerogels were fabricated with high bilirubin adsorption properties.

Cited by 45 publications

References 66 publications

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Chitosan/Diatom‐Biosilica Aerogel with Controlled Porous Structure for Rapid Hemostasis

Graphene Oxide and Reduced Graphene Oxide Nanoflakes Coated with Glycol Chitosan, Propylene Glycol Alginate, and Polydopamine: Characterization and Cytotoxicity in Human Chondrocytes

Supermacroporous Composite Cryogels in Biomedical Applications

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