Facile Incorporation of Silver Nanoparticles into Quaternized Poly(2-(Dimethylamino)Ethyl Methacrylate) Brushes as Bifunctional Antibacterial Coatings

Abstract

A simple strategy to fabricate bifunctional antibacterial coatings via in situ synthesis and incorporation of silver nanoparticles (AgNPs) into quaternized poly(2‐(dimethylamino)ethyl methacrylate) (qPDMAEMA) brushes without using any reducing agents is reported. PDMAEMA brushes are prepared on Si wafer substrates via surface‐initiated reverse atom transfer radical polymerization, which then are quaternized with ethyl bromide and hexyl bromide, respectively. The resulting qPDMAEMA‐AgNP nanocomposite coatings are characterized by using Fourier‐transform infrared spectroscopy (FT‐IR), X‐ray photoelectron spectroscopy (XPS), field emission scanning electron microscope (FE‐SEM), and Raman spectroscopy. FE‐SEM and Raman results indicate that the AgNPs with an average diameter of 35 nm are successfully loaded into the qPDMAEMA brushes. Furthermore, the antibacterial activities of the qPDMAEMA‐AgNP nanocomposite coatings against Gram‐positive Staphylococcus aureus and Gram‐negative Escherichia coli are investigated by both disc diffusion and colony‐forming unit methods. The results show excellent antibacterial properties of the nanocomposite coatings. The influence of the length of the quaternization agents on their antibacterial properties is also investigated.

Magnetic Nanoparticle-Based Drug Delivery Approaches for Preventing and Treating Biofilms in Cystic Fibrosis

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Self‐Assembled Polymeric Membranes and Nanoassemblies on Surfaces: Preparation, Characterization, and Current Applications

“…Nonactive solid‐supported polymer brushes play a role in antimicrobial applications, when combined with active elements such as antibiotic, antimicrobial peptides and nanoparticles. For instance, poly(sulfobetaine methacrylate) and poly(carboxybetaine methacrylate) brushes were used to embed silver nanoparticles which allocate the antibacterial activity . The combination of antimicrobial NP and zwitterions shows outstanding antimicrobial activity of the membrane, where the bacterial population was reduced by 100% after 6 h incubation time.…”

Development of alginate‐gum acacia‐Ag0 nanocomposites via green process for inactivation of foodborne bacteria and impact on shelf life of black grapes (Vitis vinifera)

“…In recent years, the use of biodegradable polymers has gained widespread attention for usage as food packaging due to its renewable, biodegradable, and nontoxic nature . The most advantages of biodegradable polymers are low cost, bio compatibility, and having film‐forming properties . In spite of many advantages, the high capacity of moisture absorbance of these polymers leads to grow microbes such as molds, yeast, and bacteria, which can cause food decay.…”

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“…Its nanoparticles are highly toxic to microorganisms and less toxic to eukaryotic cells . The combination of biodegradable polymers and antimicrobial Ag nanoparticles are receiving considerable attention because of their potential application in food packaging films . Several methods have been developed for the synthesis of inorganic metal‐based polymer nanocomposite films.…”