Facile green synthesis of 16-dehydropregnenolone acetate (16-DPA) from diosgenin

Baruah, Diganta; Das, Ram Nath; Konwar, Dilip

doi:10.1080/00397911.2015.1121280

Cited by 5 publications

(3 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The process is still used and subject to further optimization. 34 Of course, no one is infallible, and Marker was no exception: e.g. Longwell and Wintersteiner suspected 35 and finally Gallagher has proven 36 that the structure of Marker-Lawson acid 37 was incorrect; Wall et al 38 also pointed out that the natural or artefact status of the sapogenin texogenin isolated by Marker et al 39 is unclear.…”

Section: Early Years and Educationmentioning

confidence: 99%

The campfire stories of Russell Marker, a pioneer of chemistry

Kovács

2023

Notes Rec.

View full text Add to dashboard Cite

The maverick American chemist Russell Earl Marker (1902–1995) is known for his studies on the fragmentation of organic mercury compounds, establishing the concept of the octane number, investigating the rearrangements of hydrocarbons and exploring the relationship between optical rotation and the configuration of organic compounds. His greatest achievement, however, is the elaboration of seminal isolation and synthetic methods of an important class of natural products that helped found a new industry, based on the pharmaceutical chemistry of steroids. The nomadic life of this extraordinary man demonstrates that the enormous obstacles thwarting the progress of science and technology can be surmounted by serendipity, acumen and devotion. However, his premature retirement from chemistry is a warning sign that every scientist is vulnerable and even the toughest man's perseverance can fade if the conditions worsen.

show abstract

Section: Early Years and Educationmentioning

confidence: 99%

The campfire stories of Russell Marker, a pioneer of chemistry

Kovács

2023

Notes Rec.

View full text Add to dashboard Cite

show abstract

“…In today's era, the field of chemistry has achieved remarkable feats. The advent of green synthesis methods has significantly alleviated environmental burdens while presenting novel methods for more efficient separation and purification of reaction products to achieve high reaction yields [24][25][26][27]. During the 1980s, the microbial transformation of sterols, which are by-products of mainly soy and paper production, gained rapid development and application, offering the advantages of reduced waste and increased productivity.…”

Section: Introductionmentioning

confidence: 99%

Green Manufacturing of Steroids via Mycolicbacteria: Current Status and Development Trends

Zhao,

Li,

Xiong

et al. 2023

Fermentation

View full text Add to dashboard Cite

Steroids, the second largest drug category ranked after antibiotics, find widespread use in treatments for reproductive health, endocrine regulation, and inflammation. Advances in steroidal chemistry to date have led to the widespread use of sterols as starting substances in the development of environmentally friendly biotechnologies for steroid production, including biocatalysis, microbial transformations, and biosynthesis using engineered micro-organisms. In this review, we synthesize some of the recent advancements in steroid biocatalysis using the Mycolicibacterium species, including the identification and modification of crucial elements for enhanced production. We also delve into the detailed characterization and reconstruction of metabolic pathways in specific microbial strains, shedding light on their potential for steroid biosynthesis. Additionally, we highlight the development of innovative de novo biosynthesis pathways for steroids within engineered cell factories. These results collectively provide an overview of the current landscape and emerging trends in green steroid manufacturing within the steroidal pharmaceutical industry.

show abstract

“…The main raw materials for chemical conversion are diosgenin, a key raw material extracted from Dioscorea species , and the chemically produced 16-dehydropregnenolone acetate (Fig. 1 B), as the central intermediates for the synthesis of a large number of steroidal drugs (Baruah et al 2015 ; Herraiz 2017 ) (Fig. 1 C).…”

Section: Introductionmentioning

confidence: 99%

Rational development of mycobacteria cell factory for advancing the steroid biomanufacturing

Wang

Liu

et al. 2022

World J Microbiol Biotechnol

View full text Add to dashboard Cite

Steroidal resource occupies a vital proportion in the pharmaceutical industry attributing to their important therapeutic effects on fertility, anti-inflammatory and antiviral activities. Currently, microbial transformation from phytosterol has become the dominant strategy of steroidal drug intermediate synthesis that bypasses the traditional chemical route. Mycobacterium sp. serve as the main industrial microbial strains that are capable of introducing selective functional modifications of steroidal intermediate, which has become an indispensable platform for steroid biomanufacturing. By reviewing the progress in past two decades, the present paper concentrates mainly on the microbial rational modification aspects that include metabolic pathway editing, key enzymes engineering, material transport pathway reinforcement, toxic metabolic intermediates removal and byproduct reconciliation. In addition, progress on omics analysis and direct genetic manipulation are summarized and classified that may help reform the industrial hosts with more efficiency. The paper provides an insightful present for steroid biomanufacturing especially on the current trends and prospects of mycobacteria.

show abstract

Facile green synthesis of 16-dehydropregnenolone acetate (16-DPA) from diosgenin

Cited by 5 publications

References 15 publications

The campfire stories of Russell Marker, a pioneer of chemistry

The campfire stories of Russell Marker, a pioneer of chemistry

Green Manufacturing of Steroids via Mycolicbacteria: Current Status and Development Trends

Rational development of mycobacteria cell factory for advancing the steroid biomanufacturing

Contact Info

Product

Resources

About