Facile fabrication of redox/pH dual stimuli responsive cellulose hydrogel

Liu, Hongchen; Rong, Liduo; Wang, Bijia; Xie, Ruyi; Sui, Xiaofeng; Xu, Hong; Zhang, Linping; Zhong, Yi; Mao, Zhiping

doi:10.1016/j.carbpol.2017.08.085

Cited by 93 publications

(31 citation statements)

References 47 publications

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“…[82][83][84] In order to explore and mimic the more complex stimulation systems from nature, more researchers have developed novel hydrogel systems in which two or more stimuli-responsive mechanisms are combined, the so-called dual-responsive and multi-responsive hydrogel systems. [85][86][87][88] 3.2.1 Physical stimuli. By far the most studied and best understood response is that to temperature, which is one of the most favorable environmental stimuli that is used to trigger hydrogel systems that undergo sol-gel phase transitions or volume change at a critical solution temperature.…”

Section: Stimulation Of "Smart" Hydrogelsmentioning

confidence: 99%

Trends in polymeric shape memory hydrogels and hydrogel actuators

et al. 2019

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Section: Stimulation Of "Smart" Hydrogelsmentioning

confidence: 99%

Trends in polymeric shape memory hydrogels and hydrogel actuators

et al. 2019

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“…This behavior has been observed in ceramic materials such as bricks and glasses [ 89 ]. This behavior is somewhat counterintuitive as we expected that highly crosslinked hydrogels exhibited the highest resistance to rupture [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ,…”

Section: Resultsmentioning

confidence: 99%

“…Hydrogels are, however, subject of instability and macroscopic deformation, particularly when subjected to a considerable degree of swelling [ 13 ]. These attributes have been crucial for the development of several applications, including industrial biotransformation, antimicrobial peptide production, cell encapsulation, water and air purification and medical applications such as tissue engineering and cell therapy [ 14 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 ].…”

Section: Introductionmentioning

confidence: 99%

Formulation and Characterization of Gelatin-Based Hydrogels for the Encapsulation of Kluyveromyces lactis—Applications in Packed-Bed Reactors and Probiotics Delivery in Humans

Patarroyo¹,

Florez-Rojas²,

Pradilla³

et al. 2020

Polymers

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One of the main issues when orally administering microorganism-based probiotics is the significant loss of bioactivity as they pass through the gastrointestinal (GI) tract. To overcome these issues, here, we propose to encapsulate the probiotic yeast Kluyveromyces lactis on chemically crosslinked gelatin hydrogels as a means to protect the bioactive agents in different environments. Hydrogels were prepared by the chemical crosslinking of gelatin, which is commercially available and inexpensive. This is crucial to ensure scalability and cost-effectiveness. To explore changes in key physicochemical parameters and their impact on cell viability, we varied the concentration of the crosslinking agent (glutaraldehyde) and the gelatin. The synthesized hydrogels were characterized in terms of morphological, physical-chemical, mechanical, thermal and rheological properties. This comprehensive characterization allowed us to identify critical parameters to facilitate encapsulation and enhance cell survival. Mainly due to pore size in the range of 5–10 μm, sufficient rigidity (breaking forces of about 1 N), low brittleness and structural stability under swelling and relatively high shear conditions, we selected hydrogels with a high concentration of gelatin (7.5% (w/v)) and concentrations of the crosslinking agent of 3.0% and 5.0% (w/w) for cell encapsulation. Yeasts were encapsulated with an efficiency of about 10% and subsequently tested in bioreactor operation and GI tract simulated media, thereby leading to cell viability levels that approached 95% and 50%, respectively. After testing, the hydrogels’ firmness was only reduced to half of the initial value and maintained resistance to shear even under extreme pH conditions. The mechanisms underlying the observed mechanical response will require further investigation. These encouraging results, added to the superior structural stability after the treatments, indicate that the proposed encapsulates are suitable to overcome most of the major issues of oral administration of probiotics and open the possibility to explore additional biotech applications further.

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“…Cellulose-based hydrogels have properties that recommend them for various biomedical applications, such as targeted delivery of drugs and smart sensors, or hydrogels multi-receptive, injectable and self-healing [67,68].…”

Section: Cellulose and Cellulose Derivative-based Hydrogels Propertiesmentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

122

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Facile fabrication of redox/pH dual stimuli responsive cellulose hydrogel

Cited by 93 publications

References 47 publications

Trends in polymeric shape memory hydrogels and hydrogel actuators

Trends in polymeric shape memory hydrogels and hydrogel actuators

Formulation and Characterization of Gelatin-Based Hydrogels for the Encapsulation of Kluyveromyces lactis—Applications in Packed-Bed Reactors and Probiotics Delivery in Humans

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

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