Facile fabrication of quaternized chitosan-incorporated biomolecular patches for non-compressive haemostasis and wound healing

Chen, Zesheng; Zhang, Yixuan; Feng, Kexin; Tao, Hu; Huang, Bohan; Tang, Jiapeng; Ai, Junjie; Guo, Liang; Hu, Weikang; Wang, Zijian

doi:10.1016/j.fmre.2023.05.009

Cited by 12 publications

(6 citation statements)

References 58 publications

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“…In the previous work, the degree of substitution of GelMA was detected by 13 C nuclear magnetic resonance ( 13 C-NMR) and proved it was about 29.1%. [35] Preparation of GelMA/𝜖-PL Composite Hydrogels: The GelMA/𝜖-PL composite hydrogels (coded as GP-n HGs, n = 0, 10, 20, and 30, respectively) with different content of 𝜖-PL were prepared by UV-mediated crosslinking. Briefly, GelMA powder was dissolved into distilled water to prepare a 15% GelMA solution.…”

Section: Methodsmentioning

confidence: 99%

Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

Chen,

Hu,

Wang

et al. 2023

Adv Healthcare Materials

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Applying antibacterial polymers and pro‐regenerative small molecules are two individual strategies for accelerating wound healing. However, integrating those two unique approaches into one therapeutic platform that meets clinical requirements is still a challenge. Herein, a series of antibacterial gelatin methacrylate (GelMA)/ε‐polylysine (ε‐PL) composite hydrogels (termed as GP‐n HGs, n = 0, 10, 20 and 30, respectively) were innovatively fabricated by ultraviolet light (UV) crosslinking. The GP‐n HGs were proved to be broad‐spectrum antibacterial and biocompatible. Among those GP‐n HGs, the GP‐20 HG was selectively processed into microneedle following a mold‐casting method. Then, the glabridin was loaded into those needles to produce composite microneedle termed GP‐20@Gla MN. An S. aureus‐infected full‐thickness defect model in rats was created to evaluate the wound‐healing effect of GP‐20@Gla MN. Furthermore, an RNA sequencing assay was performed to explore the possible molecular mechanisms of glabridin in promoting tissue regeneration, and many positive routes have been summarized. This work is of significant novelty in fulfilling complex clinical needs by simultaneously optimizing the advanced microneedles' chemical compositions and physical structures. This work will provide a promising therapeutic platform for treating infected and chronic wounds.This article is protected by copyright. All rights reserved

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Section: Methodsmentioning

confidence: 99%

Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

Chen,

Hu,

Wang

et al. 2023

Adv Healthcare Materials

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“…Exosomes may play a significant role in cell-to-cell communication. Exosomes facilitate a variety of processes, including immune responses, antigen presentation, RNA interference, and tumor progression, by transferring bioactive molecules between cells [56,57]. Due to the presence of molecular constituents that originate from the cells that produce exosomes, exosome contents may be diagnostic tools and biomarkers for a wide range of diseases, including cancer.…”

Section: Exosomes Are Structurally Stable and Bioactivementioning

confidence: 99%

“…The skin is the largest organ in humans and serves as a physical barrier, mediates immune defense and thermoregulation, and acts as a tactile sensor [117,118]. Wound healing is a complex process that involves inflammation, cell migration, proliferation, and tissue remodeling [57,61,118]. Exosomes have been shown to contribute to wound healing by promoting cell migration, reducing inflammation, and stimulating tissue regeneration [57,[119][120][121][122].…”

Section: Wound Regenerationmentioning

confidence: 99%

Engineered exosomes and composite biomaterials for tissue regeneration

Hu,

Wang,

Chen

et al. 2024

Theranostics

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Exosomes, which are small vesicles enclosed by a lipid bilayer and released by many cell types, are widely dispersed and have garnered increased attention in the field of regenerative medicine due to their ability to serve as indicators of diseases and agents with therapeutic potential. Exosomes play a crucial role in mediating intercellular communication through the transfer of many biomolecules, including proteins, lipids, RNA, and other molecular constituents, between cells. The targeted transport of proteins and nucleic acids to specific cells has the potential to enhance or impair specific biological functions. Exosomes have many applications, and they can be used alone or in combination with other therapeutic approaches. The examination of the unique attributes and many functions of these factors has emerged as a prominent field of study in the realm of biomedical research. This manuscript summarizes the origins and properties of exosomes, including their structural, biological, physical, and chemical aspects. This paper offers a complete examination of recent progress in tissue repair and regenerative medicine, emphasizing the possible implications of these methods in forthcoming tissue regeneration attempts.

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“…Several studies have reported the versatility of MNPs, originally designed for skin wound applications, in effectively treating wounds in the intestine and liver as well. [ 16,89,95 ]…”

Section: Mnp Treatments In Related Symptoms and Disorders Of Wounds A...mentioning

confidence: 99%

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

Zhuang,

Wang,

Feng

et al. 2023

Small

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Wounds and the subsequent formation of scars constitute a unified and complex phased process. Effective treatment is crucial; however, the diverse therapeutic approaches for different wounds and scars, as well as varying treatment needs at different stages, present significant challenges in selecting appropriate interventions. Microneedle patch (MNP), as a novel minimally invasive transdermal drug delivery system, has the potential for integrated and programmed treatment of various diseases and has shown promising applications in different types of wounds and scars. In this comprehensive review, the latest applications and biotechnological innovations of MNPs in these fields are thoroughly explored, summarizing their powerful abilities to accelerate healing, inhibit scar formation, and manage related symptoms. Moreover, potential applications in various scenarios are discussed. Additionally, the side effects, manufacturing processes, and material selection to explore the clinical translational potential are investigated. This groundwork can provide a theoretical basis and serve as a catalyst for future innovations in the pursuit of favorable therapeutic options for skin tissue regeneration.

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Facile fabrication of quaternized chitosan-incorporated biomolecular patches for non-compressive haemostasis and wound healing

Cited by 12 publications

References 58 publications

Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

Local Delivery of Glabridin by Biomolecular Microneedle to Accelerate Infected Wound Healing

Engineered exosomes and composite biomaterials for tissue regeneration

Targeting Diverse Wounds and Scars: Recent Innovative Bio‐design of Microneedle Patch for Comprehensive Management

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