Abstract:This study reports a new approach for the facile fabrication of calcium peroxide (CaO2) nanoparticles using tannic acid (TA) as the coordinate bridge between calcium ions. Tannylated-CaO2 (TA/CaO2) nanoparticles were prepared by reacting calcium chloride (CaCl2) with hydrogen peroxide (H2O2) in ethanol containing ammonia and different amounts of TA (10, 25, and 50 mg). The prepared TA/CaO2 aggregates consisted of nanoparticles 25–31 nm in size. The nanoparticles prepared using 10 mg of TA in the precursor solu… Show more
“…Moreover, as TA can coordinate with metal ions, it can be used to synthesize inorganic Ag and Au nanomaterials [ 25 ]. Our group recently prepared oxygen-generating calcium peroxide using TA through coordination between the catechol moieties of TA and calcium ions [ 26 ].…”
Calcium carbonate (CaCO3)-based materials have received notable attention for biomedical applications owing to their safety and beneficial characteristics, such as pH sensitivity, carbon dioxide (CO2) gas generation, and antacid properties. Herein, to additionally incorporate antioxidant and anti-inflammatory functions, we prepared tannylated CaCO3 (TA-CaCO3) materials using a simple reaction between tannic acid (TA), calcium (Ca2+), and carbonate (CO32−) ions. TA-CaCO3 synthesized at a molar ratio of 1:75 (TA:calcium chloride (CaCl2)/sodium carbonate (Na2CO3)) showed 3–6 μm particles, comprising small nanoparticles in a size range of 17–41 nm. The TA-CaCO3 materials could efficiently neutralize the acid solution and scavenge free radicals. In addition, these materials could significantly reduce the mRNA levels of pro-inflammatory factors and intracellular reactive oxygen species, and protect chondrocytes from toxic hydrogen peroxide conditions. Thus, in addition to their antacid property, the prepared TA-CaCO3 materials exert excellent antioxidant and anti-inflammatory effects through the introduction of TA molecules. Therefore, TA-CaCO3 materials can potentially be used to treat inflammatory cells or diseases.
“…Moreover, as TA can coordinate with metal ions, it can be used to synthesize inorganic Ag and Au nanomaterials [ 25 ]. Our group recently prepared oxygen-generating calcium peroxide using TA through coordination between the catechol moieties of TA and calcium ions [ 26 ].…”
Calcium carbonate (CaCO3)-based materials have received notable attention for biomedical applications owing to their safety and beneficial characteristics, such as pH sensitivity, carbon dioxide (CO2) gas generation, and antacid properties. Herein, to additionally incorporate antioxidant and anti-inflammatory functions, we prepared tannylated CaCO3 (TA-CaCO3) materials using a simple reaction between tannic acid (TA), calcium (Ca2+), and carbonate (CO32−) ions. TA-CaCO3 synthesized at a molar ratio of 1:75 (TA:calcium chloride (CaCl2)/sodium carbonate (Na2CO3)) showed 3–6 μm particles, comprising small nanoparticles in a size range of 17–41 nm. The TA-CaCO3 materials could efficiently neutralize the acid solution and scavenge free radicals. In addition, these materials could significantly reduce the mRNA levels of pro-inflammatory factors and intracellular reactive oxygen species, and protect chondrocytes from toxic hydrogen peroxide conditions. Thus, in addition to their antacid property, the prepared TA-CaCO3 materials exert excellent antioxidant and anti-inflammatory effects through the introduction of TA molecules. Therefore, TA-CaCO3 materials can potentially be used to treat inflammatory cells or diseases.
“…2.2 Synthesis of CaO 2 nanoparticles: CaO 2 nanoparticles were synthesized at room temperature according to a previous report [9]. Firstly, 2 mol L − 1 CaCl 2 aqueous solution was prepared as the original solution.…”
During wound healing, oxygen availability and anti-inflammatory microenvironment play an important role in the formation of new tissue. However, whether to provide continuous and controllable oxygen around the injured tissue while inhibiting inflammation, and realize the synergistic effect of oxygen supply and anti-inflammation, is still a major problem affecting the regeneration and repair of wound tissue. Inspired by skin wound pathology and the inflammatory microenvironment, a photothermal response-assisted strategy has been developed in this work. We prepared composite hydrogel system of PDA-HA (polydopamine-hyaluronic acid) hydrogel-loaded CaO2-ICG@LA@MnO2 (calcium peroxide-indocyanine green @ lauric acid @ manganese dioxide) nanoparticles, which showed excellent photothermal performance under near-infrared (NIR) irradiation, and realized the on-off release of oxygen and reactive oxygen species (ROS). Controlled and sustained oxygen release can promote the regeneration and repair of damaged tissue, and the generated ROS can effectively inhibit the outbreak of inflammation at the initial stage of wound healing. We believe that the system we have obtained can be used as a new approach for treating chronic wound healing.
“…In addition, hyaluronic acid (HA), sodium hyaluronate (SH), and tannic acid (TA) are also used for surface modification of MO 2 . For example, after stabilization by HA, CaO 2 can remain stable in the humoral environment, and can only be degraded in the acidic TME to achieve material stabilization and tumor targeting [ 20 , 29 , 36 ]. To sum up, proper surface modification not only increases the stability of MO 2 , but also improves the dispersion of NPs, even be possible to target tumor.…”
Section: Synthesis and Surface Modification Of Momentioning
In recent years, metal peroxide (MO
2
) such as CaO
2
has received more and more attention in cancer treatment. MO
2
is readily decompose to release metal ions and hydrogen peroxide in the acidic tumor microenvironment (TME), resulting metal ions overloading, decreased acidity and elevated oxidative stress in TME. All of these changes making MO
2
an excellent tumor therapeutic agent. Moreover, by combining MO
2
with photosensitizers, enzymes or Fenton reagents, MO
2
can assist and promote various tumor therapies such as photodynamic therapy and chemodynamic therapy. In this review, the synthesis and modification methods of MO
2
are introduced, and the representative studies of MO
2
-based tumor monotherapy and combination therapy are discussed in detail. Finally, the current challenges and prospects of MO
2
in the field of tumor therapy are emphasized to promote the development of MO
2
-based cancer treatment.
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