In this paper, the mesoporous silica MCM-41 supporting nano zero valent iron (MSNZVI) composite was synthesized in a facile way and characterized by XRD, FT-IR, TEM and N 2 adsorption-desorption. The catalytic activity of the as-prepared MSNZVI composite as a catalyst was evaluated on the p-nitrophenol reduction in the presence of excess NaBH 4 . And the rate constant is 4.89 9 10 -3 s -1 when the mole ratio of NaBH 4 to p-nitrophenol is 500. MSNZVI composite can be reused for at least five cycles with stable catalytic activity. Moreover, a possible catalytic mechanism of MSNZVI was proposed to explain the reduction of p-nitrophenol by NaBH 4 .