Facile exfoliation of MoS₂ nanosheets by protein as a photothermal-triggered drug delivery system for synergistic tumor therapy

Abstract

A schematic representation of MoS2 nanosheet synthesis and its photothermal-triggered drug delivery application.

Functionalized Hybridization of 2D Nanomaterials

“…In our previous work, as the first biomacromolecule, bovine serum albumin (BSA) via its nonpolar groups such as benzene rings and disulfide groups was firmly bonded on TMDs (e.g., MoS 2 , WS 2 , and WSe 2 ) through their strong hydrophobic interaction (Figure 6a,b). [98] As reported, the WSe 2 -BSA nanosheets were employed as efficient photothermal moieties and photosensitizing agent carrier for photodynamic therapy (Figure 7). These outstanding features render BSA-stabilized TMD nanosheets a star materials in drug delivery system and tumor therapy.…”

Tris‐Stabilized MoS2 Nanosheets with Robust Dispersibility and Facile Surface Functionalization

“…With good biocompatibility and promising photothermal property, Tris‐stabilized MoS 2 nanosheets will be a desired agent in photothermal therapy. Herein, we deeply studied the inhibition of tumor growth by Tris‐stabilized MoS 2 nanosheets . As shown in Figure A, tumors treated with Tris‐stabilized MoS 2 nanosheets formed a scab after NIR irradiation.…”

Advanced Near‐Infrared Light‐Responsive Nanomaterials as Therapeutic Platforms for Cancer Therapy

“…[191] In recent years, facile noncovalent functionalizations have been explored with molecules such as bovine serum albumin (BSA), [192] chitosan, [187] polyvinylpyrrolidone (PVP), [179a] and other polymers. [191] In recent years, facile noncovalent functionalizations have been explored with molecules such as bovine serum albumin (BSA), [192] chitosan, [187] polyvinylpyrrolidone (PVP), [179a] and other polymers.…”

“…Upon irradiation with NIR light with different power densities, laser-power-dependent release of DOX from MoS 2 -CS-DOX was observed. [192] Efficient loading onto BSA-exfoliated MoS 2 nanosheets by hydrophobic interaction was achieved at 180% weight ratio. This result, therefore, suggested the use of NIR as a controllable trigger for drug release from the nanocomplex in vitro and in vivo, which could regulate their toxicity ( Figure 25B-E).…”

“…Overall, this strategy may allow a reduction in doses of iron oxides, magnetic field strength, and NIR excitation power to comply with in vivo settings. TiO 2-x treatment with 808 nm (1 W cm −2 ) irradiation www.advancedsciencenews.com www.advtherap.com MoS 2 Exfoliation Chitosan 80 nm (l) 4-6 nm (t) -PTT, drug delivery, CT imaging [187] MoS 2 Exfoliation -14.7 nm (hd) -PDT, down-and upconversion fluorescence Imaging [188] MoS 2 Exfoliation LA-PEG 50 nm (l) 2 nm (t) 28.4 L g −1 cm −1 at 800 nm PTT, drug delivery [191] MoS 2 Exfoliation BSA 89 nm (l) 5-15 nm (t) -PTT, drug delivery [192] MoS 2 Ionic liquid grinding Chitosan 120 nm (l) 1.4 nm (t) 62.6 L g −1 cm −1 at 800 nm PTT [194] MoS 2 Solvothermal PEG 79.2 nm (l) 0.29 nm (t) -PTT [197] MoS 2 Exfoliation -0.8 µm (l) 1.6 nm (t) 29.2 L g −1 cm −1 at 800 nm PTT [199] MoS 2 Solvothermal LA-PEG 90 nm (l) -PTT [201] MoS 2 Hydrothermal Polyacrylic acid LA-PEG 90 nm (l) -PTT [203] MoS 2 Sonication BSA 181 ± 3 nm (l) (hd) 10.65 nm (t) -PA imaging [209] MoS 2 Exfoliation DMSA-IONP-PEG-Amine LA-PEG 50-200 nm (l) -PTT, PA, MRI, and PET imaging [211] MoS 2 Hydrothermal Fe 3 O 4 PEG 190.1 nm (hd) -PTT, PA, and MRI imaging [213] MoS 2 Solvothermal Polyaniline PEG 21.5 ± 3.9 nm (hd) -PTT, RT, PA, and CT imaging [215] MoS 2 Exfoliation PEG-amine Mesoporous silica DOX 450 nm (hd) -PTT, drug delivery [223] MoS 2 Exfoliation PEI-HA DOX NOTA-64 Cu 30-50 nm (l) 5-7 nm (t) -PTT, drug delivery [224] MoS 2 Solvothermal PLGA oleosol DOX 100 nm (l) -PTT, drug delivery [225] MoS 2 Exfoliation LA-PEG PEI 90 nm (hd) -PTT, gene delivery [226] MoS 2 Exfoliation LA-PEI SH-PEG 100-150 nm (l) 6-8 nm (t) -PTT, gene delivery [227] MoS 2 Hydrothermal Gen 5 polyamidoamine (PAMAM) 420 nm (hd) -PTT, gene delivery [230] MoS 2 Exfoliation LA-PEG 100 nm (hd) 28.4 L g −1 cm −1 at 800 nm PTT, PDT, and PA imaging [231] MoS 2 Hydrothermal PEI Fe 3 O 4 ICG Pt(IV) 80 nm (hd) -PTT, PDT, PA, MRI imaging [234] WS 2 Exfoliation LA-PEG 3 ± 0.18 nm (l) -PTT, RT, PA, and CT imaging [179c] WS 2 Exfoliation BSA 20-100 nm (l) 4-5 nm (t) 21.8 L g −1 cm −1 at 808 nm PTT, PDT, and CT Imaging [186] WS 2 Exfoliation LA-PEG 50-100 nm (l) 1.6 nm (t) 23.8 L g −1 cm −1 at 808 nm PTT, PA, and CT imaging [189] WS 2 High-temperature reaction Gd 3+ C 18 PMH-PEG 90-100 nm (hd) 22.6 L g −1 cm −1 at 808 nm PTT, ...…”