Facile construction of a molecularly imprinted polymer–based electrochemical sensor for the detection of milk amyloid A

Zhang, Zhengrong; Chen, Shisheng; Ren, Jun; Han, Fang; Yu, Xiaofeng; Tang, Fang; Xue, Feng; Chen, Wei; Yang, Jielin; Jiang, Yuan; Jiang, Hongmei; Lv, Bo; Xu, Jianguo; Dai, Jianjun

doi:10.1007/s00604-020-04619-7

Cited by 13 publications

(4 citation statements)

References 29 publications

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“…Serum amyloid A is an acute-phase protein with several isoforms; SAA1, SAA2, and SAA3 are the main ones. SAA1 and SAA2 are mainly produced in the liver, while SAA3 is produced outside the liver and is mainly found in milk but not in humans [ 82 ].…”

Section: Mip Application For Detection Of Biomarkers Of Inflammation ...mentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

et al. 2023

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The appearance of biological molecules, so-called biomarkers in body fluids at abnormal concentrations, is considered a good tool for detecting disease. Biomarkers are usually looked for in the most common body fluids, such as blood, nasopharyngeal fluids, urine, tears, sweat, etc. Even with significant advances in diagnostic technology, many patients with suspected infections receive empiric antimicrobial therapy rather than appropriate treatment, which is driven by rapid identification of the infectious agent, leading to increased antimicrobial resistance. To positively impact healthcare, new tests are needed that are pathogen-specific, easy to use, and produce results quickly. Molecularly imprinted polymer (MIP)-based biosensors can achieve these general goals and have enormous potential for disease detection. This article aimed to overview recent articles dedicated to electrochemical sensors modified with MIP to detect protein-based biomarkers of certain infectious diseases in human beings, particularly the biomarkers of infectious diseases, such as HIV-1, COVID-19, Dengue virus, and others. Some biomarkers, such as C-reactive protein (CRP) found in blood tests, are not specific for a particular disease but are used to identify any inflammation process in the body and are also under consideration in this review. Other biomarkers are specific to a particular disease, e.g., SARS-CoV-2-S spike glycoprotein. This article analyzes the development of electrochemical sensors using molecular imprinting technology and the used materials’ influence. The research methods, the application of different electrodes, the influence of the polymers, and the established detection limits are reviewed and compared.

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Section: Mip Application For Detection Of Biomarkers Of Inflammation ...mentioning

confidence: 99%

Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

et al. 2023

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“…Its LOD was 7.7 × 10 −13 M, and its selectivity to D-M was about six times as high as that of other reported electrochemical sensors. In a separate study, Zhang et al [ 83 ] mixed the rGO with CS solution at a volume ratio of 1:1, and added the AuNPs for ultrasonic stirring to acquire AuNPs@rGO. Then, Py was electro-polymerized on AuNPs@rGO modified electrode.…”

Section: Applications Of Nanomaterials In Mip Sensorsmentioning

confidence: 99%

Recent Advances of Nanomaterials-Based Molecularly Imprinted Electrochemical Sensors

Dong

Zhang

et al. 2022

Nanomaterials

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Molecularly imprinted polymer (MIP) is illustrated as an analogue of a natural biological antibody-antigen system. MIP is an appropriate substrate for electrochemical sensors owing to its binding sites, which match the functional groups and spatial structure of the target analytes. However, the irregular shapes and slow electron transfer rate of MIP limit the sensitivity and conductivity of electrochemical sensors. Nanomaterials, famous for their prominent electron transfer capacity and specific surface area, are increasingly employed in modifications of MIP sensors. Staying ahead of traditional electrochemical sensors, nanomaterials-based MIP sensors represent excellent sensing and recognition capability. This review intends to illustrate their advances over the past five years. Current limitations and development prospects are also discussed.

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“…Conversely, it was recommended for polyanilinebased molecularly imprinted polymers to be produced in a basic environment, which is noted as unlikely, due to the polymer being formed in strongly acidic environments and effectively making PPy the more favourable choice of polymer for molecularly imprinted L-tryptophan sensors [18]. Theoretical predictions, especially assisted by computers, can also be used to design composite materials for molecularly imprinted polymer sensors [19]. In a recent study, the interactions between the components of the composite, which included multi-walled carbon nanotubes, and the intended analyte, bisphenol A, particularly the conjugation of bisphenol A and the nanotube surface were predicted.…”

Section: Theoretical Considerationsmentioning

confidence: 99%

“…Consequently, a serum amyloid A sensor has been developed, utilising a MIPPy layer, with the imprinting being conducted by first depositing the amyloid A onto the electrode, followed by coating it in polypyrrole. In order to remove the template, the electrode was immersed for an hour in an acetic acid solution [19].…”

Section: Detection Of Bio-active Substancesmentioning

confidence: 99%

Electropolymerised Polypyrroles as Active Layers for Molecularly Imprinted Sensors: Fabrication and Applications

Glosz

Stolarczyk

2021

Materials

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Conjugated polymers are widely used in the development of sensors, but even though they are sensitive and robust, they typically show limited selectivity, being cross-sensitive to many substances. In turn, molecular imprinting is a method involving modification of the microstructure of the surface to incorporate cavities, whose shape matches that of the “template”—the analyte to be detected, resulting in high selectivity. The primary goal of this review is to report on and briefly explain the most relevant recent developments related to sensors utilising molecularly imprinted polypyrrole layers and their applications, particularly regarding the detection of bioactive substances. The key approaches to depositing such layers and the most relevant types of analytes are highlighted, and the various trends in the development of this type of sensors are explored.

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Facile construction of a molecularly imprinted polymer–based electrochemical sensor for the detection of milk amyloid A

Cited by 13 publications

References 29 publications

Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

Molecularly Imprinted Polymer-Based Electrochemical Sensors for the Diagnosis of Infectious Diseases

Recent Advances of Nanomaterials-Based Molecularly Imprinted Electrochemical Sensors

Electropolymerised Polypyrroles as Active Layers for Molecularly Imprinted Sensors: Fabrication and Applications

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