Facile and simple preparation of pH-sensitive chitosan-mesoporous silica nanoparticles for future breast cancer treatment

Abstract

Abstract. The nanocarrier is linked to the core and shell by hydrogen bond. This drug delivery system represents a smart, biodegradable, and pH-sensitive nanocarrier for breast cancer therapy. These drug nanocarriers were linked by hydrogen bond from -NH 2 on chitosan and -OH on mesoporous silica nanoparticle (MSN). And MSN was prepared by the cetyltrimethyl ammonium bromide (CTAB)-templated method via sol-gel and the loading of ibuprofen (IBU) into the pores of MSN was visualized by coprecipitation which was assessed by Fourier Transform Infrared Spectroscopy (FTIR) and nitrogen adsorption-desorption techniques. The wrapping of chitosan (CS) onto the surface of MSN was demonstrated by FTIR too. When the nanocarriers entered an acidic environment where large quantity cancer cells existed, the chitosan shell swell into loose random coil, exposing the drug and making them easy to be released. The results showed that the IBU could be successfully and effectively loaded into MSN and CS/MSN. The system was pH responsive. Drug release was much higher at pH 6.8 than at 7.4. This drug delivery system will represent a smart and biodegradable pH-responsive nanocarrier for breast cancer.

pH-Responsive Mesoporous Silica and Carbon Nanoparticles for Drug Delivery

“…Chitosan can be directly adsorbed by hydrogen bonding onto the surface to form a single protective layer. When pH drops, the amine groups get protonated, and the polymer shell swells reversely, allowing the release and making it a good on/off pH-responsive system [ 140 , 141 , 142 , 143 ]. The covalent bonding of chitosan onto the surface through cross-linking chemistry has also been reported [ 155 , 156 , 157 , 158 ].…”

Interactions between bovine serum albumin and mesoporous silica nanoparticles functionalized with biopolymers

“…Moreover, the external surface of MSNs can easily be functionalized with target biomolecules, i.e. proteins/antibodies [27][28][29], peptides [30,31] or saccharides [32][33][34], that can be recognized by receptors overexpressed by tumor cells [35][36][37]. Alternatively, these macromolecules can modify their conformation, as a response to a change of environmental conditions (i.e.…”

Mesoporous silica nanoparticles functionalized with hyaluronic acid. Effect of the biopolymer chain length on cell internalization

“…Target molecules allow the MSNs to reach the tumor tissue only through a molecular recognition mechanism. Then, once in the internal tissue, the stimuliresponsive capping agent [5,34] permits the release of the drug as a response to internal (change of pH [42][43][44][45], temperature [46][47][48], redox reactions [40,[49][50][51][52]) or external (irradiation with light [53][54][55], magnetic field [55][56][57]) stimuli.…”