Facile and Manifest Liquid Chromatographic Method for the Simultaneous Determination of Enalpril Maleate and NSAIDs in API and Pharmaceutical Formulations

Sultana, Najma; Sattar, Naveed

doi:10.4172/2153-2435.s2-004

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…Effluents from the column were monitored at 225nm. [17] ACE inhibitors alone are not sufficient to decrease high blood pressure hence, they are used in as combination with other particular classes of drug compounds such as calcium channel blocker antihypertensives, diuretics, and etc another method is reported of enalapril with diuretic Hydrochlorothiazide and Furosemide in Active Pharmaceutical Ingredients, Pharmaceutical Dosage Forms and Human Serum [18]. Simultaneous LC determination of, lisinopril, rosuvastatin, captopril, and enalapril in API, pharmaceutical dosage formulations, and human serum [19] other methods of enalapril with hypoglycemics (glibenclamide .metformin, glimepride) statins and H2 receptor antagonist in bulk, formulations and human serum by RP-HPLC [20][21][22] are reported (Figure 1).…”

Section: Methods Of Assaymentioning

confidence: 99%

"An Overview of Enalapril by UV Spectrophotometer and HPLC"

Sattar¹

2018

MAPP

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Present review article determine the analytical methods for the quantitative determinations of Enalapril (ACE Inhibitor) by one of the spectroscopic technique (UV spectrophotometry) and separation technique such as High-Performance Liquid chromatography (HPLC).Pharmaceuticals dosage formulations and human serum is needed for effective analytical procedure and quality control of Enalapril in clinical and pharmaceutical practices. An extensive survey of the literature published in various pharmaceutical and analytical chemistry related journals has been compiled in its review. A synopsis of reported spectrophotometer and high-performance liquid chromatographic methods for Enalapril is integrated. This appraisal illustrate that majority of the HPLC methods reviewed are based on the quantitative analysis of drug in API (active Pharmaceutical ingredients) biological fluids and they are appropriate for therapeutic drug monitoring purpose.

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Section: Methods Of Assaymentioning

confidence: 99%

"An Overview of Enalapril by UV Spectrophotometer and HPLC"

Sattar¹

2018

MAPP

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“…Taking this into account we have worked on a number of in vitro interactions of enalapril with hypoglycemic agents 14 Lefunomide with NSAIDs 15 , enalapril maleate and H 2 -receptor antagonists 16 . To quantitate these interactions we reported simple and economical HPLC-UV methods for the quantitation of these drugs alone 17 as well as in combinations 18,19 .Diabetic patients who take a combination of medications especially NSAIDS are prone to drug interactions, so it is necessary to study these interactions with respect to the pharmacokinetics of the combined dosage forms. Thus our research group reported a number of in vivo interactions of NSAIDS with leflunomide 20 , as well as hypoglycemic agents 21,22 on Carrageenan Induced Inflammations.…”

Section: Enalapril Maleate Chemically Described As (S)-1-[n-[1-(ethoxmentioning

confidence: 99%

In Vivo and in Vitro Interaction Studies of Enalapril With Flurbiprofen on Carrageenan Induced Inflammation Rats (Ciir)

Sattar

Sultana

Arayne

2014

J. Chil. Chem. Soc.

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Both ACE inhibitors and non steroidal anti-inflammatory drugs (NSAIDs) are prescribed together in the elderly as different diseases may occur together. In vivo and in vitro interaction studies of ACE inhibitor (enalapril) was carried out with commonly used NSAID, flurbiprofen in carrageenan induced inflammation (CIIR) rats to check the anti-inflammatory response of NSAIDs in presence of enalapril and alone. In present study, altered anti-inflammatory response was observed for flurbiprofen when given simultaneously with enalapril by comparing decrease in paw size. Results were expressed in % reduction in paw size for every hour and were calculated for edema rate and percentage reduction. In vitro interaction studies carried out using HPLC and both the drugs were analyzed by assaying both drugs alone and in combination.The combination of enalapril and flurbiprofen showed increased activity of flurbiprofen as depicted by increase of % reduction and decrease in edema rate. It was also proved from AUC of the chromatogram of combine drugs. Since this study has certain limitation as a number of tested animals were small and the duration of anti-inflammatory response was checked for flurbiprofen alone and in combination with enalapril for few hours, further studies may be required to establish the strong relationship.

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“…We reported a method to quantitate enalapril with NSAIDs simultaneously using high performance liquid chromatography (HPLC)-UV technique which was used to study the in vitro interactions [10].…”

Section: A Rt I C L E I N F O Abstractmentioning

confidence: 99%