Facial Rejuvenation After Intradermal Botulinum Toxin: Is it Really the Botulinum Toxin or is it the Pricks?

Kapoor, Rinky; Shome, Debraj; Jain, Vandana; Dikshit, Rajesh

doi:10.1111/j.1524-4725.2010.01703.x

Cited by 36 publications

(50 citation statements)

References 8 publications

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“…9 As this procedure could be performed by injecting multiple tiny aliquots of a more diluted concentration of BTA than traditional dilution into dermis, the collagen production found after treatment may probably cause by needle pricks, not BTA itself. 10 In addition, few split-face comparison studies on OnabotulinumtoxinA (ONA) demonstrated no clinical efficacy on face-lifting effect when comparing to normal saline solution (NSS) using intradermal injection technique. 9,10 To the best of our knowledge, this was the first study to compare the face-lifting effect of ABO intradermal injection and NSS.…”

Section: Discussionmentioning

confidence: 99%

“…10 In addition, few split-face comparison studies on OnabotulinumtoxinA (ONA) demonstrated no clinical efficacy on face-lifting effect when comparing to normal saline solution (NSS) using intradermal injection technique. 9,10 To the best of our knowledge, this was the first study to compare the face-lifting effect of ABO intradermal injection and NSS. Even though, we found that there was a statistically significant difference in face-lifting effect when comparing between ABO and NSS.…”

Section: Discussionmentioning

confidence: 99%

“…Few split-face comparison studies on Onabotulinum-toxinA (ONA) demonstrated no clinical efficacy on facelifting effect when comparing to normal saline solution (NSS) using intradermal injection technique. 9,10 Until now, there is no split-face comparison study on facelifting effect of abobotulinumtoxinA (ABO). Therefore, the objective of this study was to determine the facelifting effect of ABO intradermal injection and NSS.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The comparison between intradermal injection of abobotulinumtoxinA and normal saline for face‐lifting: a split‐face randomized controlled trial

Wanitphakdeedecha

Ungaksornpairote

Kaewkes

et al. 2016

J of Cosmetic Dermatology

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SummaryBackground Botulinum toxin type A (BTA) has been approved for the treatment of strabismus, blepharospasm, muscle spasm, cervical dystonia, pain syndrome, glabella wrinkles, and severe primary axillary hyperhidrosis. Intradermal injection of BTA has been used off-label by many clinicians for the purpose of face-lifting effect. Few studies on onabotulinumtoxinA (ONA) demonstrated no clinical efficacy on facelifting effect when comparing to normal saline solution (NSS). So far, there is no split-face comparison study on face-lifting effect of abobotulinumtoxinA (ABO). Objective To determine the face-lifting effect of ABO intradermal injection and NSS. Methods Twenty-two subjects with symmetrical faces on both facial expression and expressionless were randomly injected with ABO at 1:7 cc dilution (500 unit or one vial in 7 cc of NSS) on one side and NSS on the other side using intradermal injection technique. Standardized photographic documentation was obtained at baseline, and at 2 weeks after treatment. The face-lifting effect was graded by two blinded dermatologists using photographic comparison and rated by the patients. Side effects were also recorded at the end of the study. Results Face-lifting effect was demonstrated in 40.9% and 4.5% of patients with ABO and NSS, respectively. There was a statistically significant difference in face-lifting effect when comparing between ABO and NSS (P = 0.021). The face-lifting was reported in 50.0% of patients receiving ABO injection. The patients with oval-face shape tended to respond better with ABO (P = 0.046). The odd of face-lifting effect for patients aged younger than 32 was higher than patients aged older than 32 with the odds ratio of 7.9 and 95% confidence interval of 1.1-56.1. Facial asymmetry was found in 22.7% of subjects. Conclusions This study demonstrated the face-lifting effect of ABO intradermal injection. Patients with oval-face shape and aged younger than 32 tended to respond better. Therefore, patient selection should be emphasized to improve efficacy of this technique.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The comparison between intradermal injection of abobotulinumtoxinA and normal saline for face‐lifting: a split‐face randomized controlled trial

Wanitphakdeedecha

Ungaksornpairote

Kaewkes

et al. 2016

J of Cosmetic Dermatology

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“…One may reasonably suspect that an effect might be produced on adjacent tissue components after BoNT injection, but what makes this argument even more interesting is that percutaneous needle pricks themselves have been reported to create multiple microbruises in the dermis and to initiate a complex cascade of growth factors that eventually results in collagen production. Thus, intradermal BoNT injection might not have any benefit for facial rejuvenation, the purported benefits of skin rejuvenation being due to the collagenesis caused by the needle pricks . Therefore, studies of BoNT effects on collagenesis of human dermal fibroblasts in vitro that exclude the effects of needles must be designed.…”

Section: Discussionmentioning

confidence: 99%

The Potential Effect of Botulinum Toxin Type A on Human Dermal Fibroblasts: An In Vitro Study

Lee

Seo

et al. 2012

Dermatologic Surgery

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“…46 They considered it debatable whether the postulated effects are truly due to an intradermal mechanism of action or to the spread of botulinum toxin to underlying and adjacent muscles. From an evidence-based perspective, large, placebo-controlled trials would be required to evaluate the efficacy of intradermal botulinum toxin injection.…”

Section: Position Statementsmentioning

confidence: 99%

Aesthetic Applications of Botulinum Toxin A in Asians: An International, Multidisciplinary, Pan-Asian Consensus

Sundaram

Huang

Hsu³

et al. 2016

Plastic and Reconstructive Surgery - Global Open

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Background:Botulinum toxin type A remains the most popular nonsurgical aesthetic treatment worldwide. Previous consensus statements have focused on Caucasians and on Koreans as generally representative of Asians. However, indications and dosages vary among different ethnic groups. This publication reports the results of a multidisciplinary, pan-Asian consensus focusing on incobotulinumtoxinA.Methods:A consensus group of plastic surgeons and dermatologists from Asia, Europe, and the United States convened for a live meeting in Asia, followed by a questionnaire-based Delphi procedure. Treatment of Asians in both their native countries and countries of migration was discussed.Results:For most items, the group achieved a majority consensus. A number of treatment indications, strategies, and dosages were identified in Asians, which are distinct to those previously described for Caucasians due to differences in facial morphotypes, anatomy, and cultural expectations. The group also formulated position statements for intradermal botulinum toxin type A (“mesotoxin”), body shaping with the calves as a paradigm, and reduction of parotid glands. While Asians have previously been considered a homogeneous group for the purposes of aesthetic treatment, this publication considers regional variations. A new classification of Asian facial morphotypes is proposed to aid treatment planning and implementation.Conclusions:This is the first pan-Asian consensus for aesthetic use of botulinum toxin type A. Its unique objective is to optimize treatment safety and efficacy for patients of complete or part-Asian ancestry in all regions. The recommendations for incobotulinumtoxinA may be extended with care to other botulinum toxin formulations.

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Facial Rejuvenation After Intradermal Botulinum Toxin: Is it Really the Botulinum Toxin or is it the Pricks?

Abstract: Intradermal botulinum toxin A injection does not appear to have any benefit in facial rejuvenation.

Cited by 36 publications

References 8 publications

The comparison between intradermal injection of abobotulinumtoxinA and normal saline for face‐lifting: a split‐face randomized controlled trial

The comparison between intradermal injection of abobotulinumtoxinA and normal saline for face‐lifting: a split‐face randomized controlled trial

The Potential Effect of Botulinum Toxin Type A on Human Dermal Fibroblasts: An In Vitro Study

Aesthetic Applications of Botulinum Toxin A in Asians: An International, Multidisciplinary, Pan-Asian Consensus

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