Facial pain and anxiety-like behavior are reduced by pregabalin in a model of facial carcinoma in rats

Gambeta, Eder; Kopruszinski, Caroline Machado; Reis, Renata Cristiane dos; Zanoveli, Janaína Menezes

doi:10.1016/j.neuropharm.2017.07.035

Cited by 11 publications

(3 citation statements)

References 74 publications

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“…Recent evidence indicate the beneficial effects of PGB for modulation of mood and anxiety symptoms in patients with autism (Courtenay, Jaydeokar, & Perera, 2017). PGB decreased grooming in open field in adult rats (Zimcikova et al., 2017) and reduced anxiety‐like behavior after spinal cord injury and in a model of facial carcinoma in plus maze test in rats (Baastrup, Jensen, & Finnerup, 2018; Gambeta, Kopruszinski, Dos Reis, Zanoveli, & Chichorro, 2017). The underlying mechanism (s) for sex differences response to PGB treatment during gestational period is not determined yet and needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Prenatal pregabalin is associated with sex‐dependent alterations in some behavioral parameters in valproic acid‐induced autism in rat offspring

Meymandi

Sepehri

Moslemizadeh

et al. 2020

Intl J of Devlp Neuroscience

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This study was performed to evaluate the effects of prenatal exposure to pregabalin (PGB) on behavioral changes of rat offspring in an animal model of valproic acid (VPA)-induced autism-like symptoms. Pregnant rats received VPA (600 mg/kg/i.p.) once at 12.5 gestational days for autism-like symptom induction in offspring. After the delivery single male and single female offspring from each mother were randomly selected for behavioral test (anxiety, pain response, pleasure, and motor function) at 60th day adulthood (n = 7). Offspring received prenatal PGB (15 & 30 mg/kg/i.p.) during gestational days 9.5 to 15.5 either alone or in combination with VPA (PGB15, PGB30, PGB15 + VPA, and PGB30 + VPA). Control offspring received normal saline during the same period. The result showed that prenatal VPA exposure was associated with autism-like behaviors in rat offspring. PGB treatment during the gestational period revealed significant reduction in sucrose preference test and anxiety in elevated plus maze and open field test in offspring. Also, PGB treatments exhibited a dose-dependent increase in pain threshold in prenatally VPA exposed rats in tail-flick and hot plate test. Also, there was a sex-related significant impairment in motor function in beam balance and open field test, and male rats were affected more than females. However, no significant sex differences in sucrose preference and pain sensitivity were observed in prenatal PGB-treated rat offspring. In conclusion, prenatal exposure to VPA increased the risk of autism-like behaviors in the offspring rats, and PGB treatment during the gestational period was associated with some beneficial effects, including anxiety reduction and motor impairment in autism-like symptoms in rat offspring. K E Y W O R D S anhedonia, anxiety, autism, pain, pregabalin, valproic acid | 501 SHAMSI MEYMANDI Et Al. 1 | INTRODUCTION Autism spectrum disorder (ASD) is a complicated, behaviorally defined disorder, including communication and social interaction deficits and restricted, repetitive and stereotyped behaviors (Bolte et al., 2019). Prevalence estimates and diagnosis rates of ASD have risen substantially in the last two decades reaching 1.5% in developed countries (Lyall et al., 2017). According to the World Health Organization (WHO) report in 2018, 1 in 160 children had ASD. In most of cases, ASD is associated with epilepsy, since different studies showed that 22% to 38% of children with autism also suffer from comorbid epilepsy (

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Section: Discussionmentioning

confidence: 99%

Prenatal pregabalin is associated with sex‐dependent alterations in some behavioral parameters in valproic acid‐induced autism in rat offspring

Meymandi

Sepehri

Moslemizadeh

et al. 2020

Intl J of Devlp Neuroscience

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“…Based on an a priori power analysis using the GPower 3.1 software (14), which, with a large standardized effect size of F = 0.5, power of 0.8, and α = 0.05, estimated eight rats per group. Based on this observation, in previous studies that have used the same animal models (12,15,16) and considering replacement, reduction, and refinement in optimizing animal use, it was determined a sample size of 6–9 animals per group.…”

Section: Methodsmentioning

confidence: 99%

Contribution of intraganglionic CGRP to migraine-like responses in male and female rats

et al. 2019

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Objective To evaluate whether intraganglionic calcitonin gene-related peptide induced differential migraine-like responses in male and female rats. Methods Calcitonin gene-related peptide was injected in the trigeminal ganglion of male and female rats followed by assessment of periorbital mechanical allodynia with von Frey hairs. The influence of systemic treatment with sumatriptan or intraganglionic treatment with minocycline and propentofylline was determined on the calcitonin gene-related peptide-induced mechanical allodynia in male and female rats. One additional group was exposed to an aversive light 24 h after calcitonin gene-related peptide priming, followed by evaluation of periorbital mechanical threshold, and another group was tested in the elevated-plus maze. Results Intraganglionar calcitonin gene-related peptide-induced periorbital mechanical allodynia in female (0.5 to 6 h) and male rats (0.5 to 4 h). Systemic sumatriptan briefly attenuated the mechanical allodynia, but intraganglionar minocycline or propentofylline injection was effective only in male rats. Calcitonin gene-related peptide induced photic sensitivity in female and male rats (lasting 4 h and 1 h, respectively), as well as anxiety-like behavior. Conclusions Intraganglionar calcitonin gene-related peptide may play a major role in migraine-like responses, including periorbital mechanical allodynia, light sensitivity and anxiety like-behavior. Female rats are likely to be more susceptible to calcitonin gene-related peptide effects and a better understanding of the sexual dimorphism in calcitonin gene-related peptide signaling may help to improve migraine therapy.

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“…The study used two small groups of n = 3 at two different doses, which were combined for statistical analysis (n = 6): 35 mg/kg, based on behavioural studies (Field et al, 2001;Gambeta et al, 2017), and one which showed reduced theta frequency in reticular-stimulation under-anaesthesia experiment (Siok et al, 2009); 17.5 mg/kg, i.e., exactly half the higher dose, since pregabalin can effectively reduce anxiety behaviour in rodent models at doses as low as 10 mg/kg (Field et al, 2001).…”

Section: Drugs and Administrationmentioning

confidence: 99%

Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory

Hines

Poulter

Douchamps

et al. 2023

Front. Syst. Neurosci.

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Hippocampal theta frequency is a somewhat neglected topic relative to theta power, phase, coherence, and cross-frequency coupling. Accordingly, here we review and present new data on variation in hippocampal theta frequency, focusing on functional associations (temporal coding, anxiety reduction, learning, and memory). Taking the rodent hippocampal theta frequency to running-speed relationship as a model, we identify two doubly-dissociable frequency components: (a) the slope component of the theta frequency-to-stimulus-rate relationship (“theta slope”); and (b) its y-intercept frequency (“theta intercept”). We identify three tonic determinants of hippocampal theta frequency. (1) Hotter temperatures increase theta frequency, potentially consistent with time intervals being judged as shorter when hot. Initial evidence suggests this occurs via the “theta slope” component. (2) Anxiolytic drugs with widely-different post-synaptic and pre-synaptic primary targets share the effect of reducing the “theta intercept” component, supporting notions of a final common pathway in anxiety reduction involving the hippocampus. (3) Novelty reliably decreases, and familiarity increases, theta frequency, acting upon the “theta slope” component. The reliability of this latter finding, and the special status of novelty for learning, prompts us to propose a Novelty Elicits Slowing of Theta frequency (NEST) hypothesis, involving the following elements: (1) Theta frequency slowing in the hippocampal formation is a generalised response to novelty of different types and modalities; (2) Novelty-elicited theta slowing is a hippocampal-formation-wide adaptive response functioning to accommodate the additional need for learning entailed by novelty; (3) Lengthening the theta cycle enhances associativity; (4) Even part-cycle lengthening may boost associativity; and (5) Artificial theta stimulation aimed at enhancing learning should employ low-end theta frequencies.

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Facial pain and anxiety-like behavior are reduced by pregabalin in a model of facial carcinoma in rats

Cited by 11 publications

References 74 publications

Prenatal pregabalin is associated with sex‐dependent alterations in some behavioral parameters in valproic acid‐induced autism in rat offspring

Prenatal pregabalin is associated with sex‐dependent alterations in some behavioral parameters in valproic acid‐induced autism in rat offspring

Contribution of intraganglionic CGRP to migraine-like responses in male and female rats

Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory

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