Facial frictional melanosis in Indian patients: Defining the entity

Mutalik, Sharad; Pethe, Suresh V; Nikam, Balkrishna P; Rasal, Yashashree

doi:10.4103/cdr.cdr_6_18

Cited by 8 publications

(7 citation statements)

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“… 74 There are some reports of inflammatory hyperpigmentation induced by Demodex mites ( Demodex folliculorum and Demodex brevis ) hence the researcher may also keep in mind the such hyperpigmentation when monitoring the clinical studies related to herbs. 75 Friction has been mentioned as a distinct aetiology of hyperpigmentation in Indian patients 76 and Demodex inflammation has been associated to induce the frictional melanosis in influencing the hyperpigmentation. 77 Herbal Taraxaci, Herba Agrimoniae and Cortex Phellodendri et al have remarkable anti-mites potential along with human skin safety versus the Demodex folliculorum.…”

Section: Discussionmentioning

confidence: 99%

The Safety of Medicinal Plants Used in the Treatment of Vitiligo and Hypermelanosis: A Systematic Review of Use and Reports of Harm

Hussain¹

2021

CCID

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Introduction: Vitiligo is disfiguring and devastating condition that can humans feel stigmatic and devalued. Melasma is a general condition of hyperpigmentation particularly involving the face. The pigmentation disorders of vitiligo (hypopigmentation or depigmentation) and melasma (Hypermelanosis) are common among the world's population (around 1% for vitiligo). Objective: The identification of medicinal plants used in the treatment of vitiligo and hypermelanosis. A systematic literature review on harms associated with the medicinal plants used in the treatment of vitiligo and hypermelanosis. To review and summarize information on reported adverse drug reactions (ADRs) associated with these medicinal plants contained in (where access is available) national and global individual case safety report databases. Methods: A systematic review of the literature with special reference to all types of clinical trial and case reports using biomedical databases including Medline, EMBASE, Scopus, International Pharmaceutical Abstracts and so forth to identify medicinal plants alone or as an adjuvant with other treatments and their safety/tolerability in the treatment of vitiligo and Hypermelanosis. Other sources of this search were medicinal plants text books, pharmacopoeias and authentic websites discussing possible treatments for vitiligo/hypermelanosis. It also included databases such as VigiAccess containing data from spontaneous reporting schemes for ADRs. Results: A total of 55 articles (47 clinical trials and 8 case reports) met the inclusion criteria. Some trials did not reported safety information, some did report, but not very well. Reports of blistering, erythema, acute hepatitis and mutagenesis with Psoralea corylifolia. Adverse effects of erythema (mild to severe), phototoxic reactions, mild raise in liver transaminases, gastrointestinal disturbances, burns, itching, scaling, depigmented macules, pruritis, and giddiness with the use of psoralens. Khellin-related erythema, perilesional hyperpigmentation, gastrointestinal disturbances, mild raise in liver transaminases and orthostatic complaints. Infrequent side effects with Ginkgo biloba. Lower grade of erythema and edema reported with the use of Polypodium leucotomos. Conclusion: Primarily the retrieved clinical studies were efficacy oriented and safety parameters were secondary in priority whilst the general protocol of clinical trials requires the screening of drugs/medicinal plants on the basis of safety studies before testing the clinical aspects of efficacy. Thereby it is recommended that efficacy studies may be followed once the safety has been established for a particular medicinal plant in treating vitiligo and hypermelanosis.

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Section: Discussionmentioning

confidence: 99%

The Safety of Medicinal Plants Used in the Treatment of Vitiligo and Hypermelanosis: A Systematic Review of Use and Reports of Harm

Hussain¹

2021

CCID

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“…29,30,[61][62][63] Related to cultural practices Indigenous cultural practices, religious customs and type of clothing also play a key role in causation of a friction related skin diseases and are especially relevant in the Indian setting. 7,8,15,18,[31][32][33][34][35][36][37][38][39][40][41][42][43][44]64 Miscellaneous Certain clinically distinct frictional dermatoses are not specific to any category. Such entities, as well as those that manifest in the mucosa and nails, have been included here [Table 4].…”

Section: Occupationalmentioning

confidence: 99%

“…Non-invasive modalities such as dermoscopy are a useful diagnostic aid [Figure 10a]. 5,7,31,[78][79][80][81] In addition, patch and photo patch testing may be helpful to rule out contact dermatitis, an important differential. Diagnostic dilemma and differentiation from clinical mimics may warrant a skin biopsy [Figure 10b].…”

Section: Diagnosismentioning

confidence: 99%

Current understanding of frictional dermatoses: A review

Arora¹,

Khandpur

Bansal

et al. 2022

IJDVL

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Human skin is continually exposed to internal and external forces, dynamic as well as static. The skin is normally flexible and can resist mechanical trauma due to friction, pressure, vibration, suction and laceration to a considerable degree. However, an excess of these forces can abnormally affect the structure and function of the skin, setting the stage for the development of a skin disorder. Repetitive trauma can cause lichenification, hyperpigmentation, erythema, scaling, fissuring, blisters, ulceration and chronic alterations. Frictional dermatoses is an under-recognised entity with no clear-cut definition and encompasses a variety of terms such as frictional dermatitis, frictional melanosis, frictional pigmentary dermatoses and certain other named entities, many of which are confusing. The authors propose to define frictional dermatoses as ‘a group of disorders caused by repetitive trauma to the skin as a result of friction of varied aetiology which can have a wide range of cutaneous manifestations depending on the type of insult.’ The exact prevalence of frictional dermatoses as a separate entity is unknown. Authors who conducted this review include a group of dermatologists and post graduate students from various institutions. Literature was reviewed through PubMed, Medscape, Medline, ResearchGate and Google Scholar using the terms ‘frictional dermatitis,’ ‘friction and skin,’ ‘dermatoses and culture,’ ‘clothing dermatitis,’ ‘friction melanosis,’ ‘PPE induced dermatoses in COVID-19 era,’ etc. A total of 122 articles were reviewed and 100 articles among them were shortlisted and included in the study, after removing duplications. The review was followed up with further deliberation which resulted in the formulation of a new definition and classification of frictional dermatoses taking into account the morphology, histopathological characteristics, anatomical region affected and the major predisposing factors. The rising incidence of mechanical dermatoses in the COVID-19 era was also emphasised.

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“…On the facial lesions, dermatoscopy shows a patchy arrangement of bluish-gray pigment globules with dilated follicular openings. [ 28 ]…”

Section: Dermatoscopy Of Hyperpigmentary Diseasesmentioning

confidence: 99%