Face Transplantation in a Highly Sensitized Recipient

Davis, Stephen C.; Pisanni, Franco; Montero, Ramon B.

doi:10.7205/milmed-d-16-00288

Cited by 4 publications

(5 citation statements)

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“…In accordance to Chandraker et al, (23) autografts have been the gold standard for treating skin defects. It has been shown that this treatment regimen has a lot of risks including long healing time, low survival rate, limited source and new defect of the donor site.…”

Section: Discussionmentioning

confidence: 78%

Collagen Chitosan Scaffolds on Induced Skin Defect in a Rat Model (An Experimental Study)

Aboulgheit

Abdelkader

Aboushelib

et al. 2021

Alexandria Dental Journal

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BACKGROUND: Over the past ten years, an alternative for maxillofacial reconstruction was offered through regenerative medicine. It provided a new scope for improving the reconstruction of the oral and maxillofacial structures whether they are hard tissues which include the teeth and bone or the soft tissues like the oral mucosa, skin, nerves and blood vessels. OBJECTIVES: The aim of this study is to evaluate the effect of the collagen chitosan scaffolds on the duration and quality of skin surface healing. MATERIALS AND METHODS: An experimental in vivo comparative study was conducted, on twelve adult male Sprague-Dawley rats, where an induced skin wound was made on the backs of rats and then classified into two groups; 1-control group and 2-scaffold group. The effect of the collagen-chitosan scaffolds on the duration and quality of skin surface healing were assessed using Masson's trichrome staining for collagen fibers and the imageJ software to calculate % area after wound healing also the number of CD 68 macrophages was counted using histological sections then the two groups were compared using student t-test (p<0.05). RESULTS: The scaffold group showed accelerated wound healing in comparison to the control group and with a significant result. Quality of healed skin was significantly better in the scaffold treated group, which is attributed to the better collagen alignment and deposition in the stained histological sections indicated by the % area after wound healing. The number of CD 68 macrophages was higher in the scaffold group compared to the control group. CONCLUSION: The collagen chitosan scaffolds can be considered as a treatment regimen for treating skin wounds.

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Section: Discussionmentioning

confidence: 78%

Collagen Chitosan Scaffolds on Induced Skin Defect in a Rat Model (An Experimental Study)

Aboulgheit

Abdelkader

Aboushelib

et al. 2021

Alexandria Dental Journal

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“…Chandraker et al, describe the case of a full facial allograft performed in a mother of two suffering with 80% chemical burns with a 6/6 HLA mismatch and 98% pre-VCA PRA status. 18 Despite initial treatment with plasmapheresis, she developed AMR on post-operative day five. In our series of sensitised patients, no evidence of graft vasculopathy was reported.…”

Section: Discussionmentioning

confidence: 99%

“…Acute resuscitative measures following initial injury were briefly reported in a single paper. 18 Four of the contacted authors provided additional information regarding resuscitative treatment modalities implemented prior to VCA transplantation. Twenty-seven articles reported that patients underwent surgical procedures prior to reconstructive transplantation, all were autologous reconstructive procedures, and none reported the use of cadaveric skin grafting as a temporary coverage modality.…”

Section: Sensitising Eventsmentioning

confidence: 99%

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Pre-transplant management and sensitisation in vascularised composite allotransplantation: A systematic review

Geoghegan

Al-Khalil

Scarborough

et al. 2020

Journal of Plastic, Reconstructive & Aesthetic Surgery

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Introduction : Vascularised composite allotransplantation (VCA) permits like-forlike reconstruction following extensive soft tissue injuries. The initial management of extensive soft tissue injury can lead to the development of anti-HLA antibodies through injury-related factors, transfusion and cadaveric grafting. The role of antibody-mediated rejection, donorspecific antibody formation and graft rejection in the context of VCA remains unclear. This systematic review aimed to determine whether pre-transplant management strategies influence immunological outcome following VCA. Methods : A systematic review of MEDLINE, EMBASE and CINAHL using a PRISMA-compliant methodology up to February 2019 was conducted. Pre-transplant, procedural and long-term outcome data were collected and recorded for all VCA recipients on an individual patient basis. Results : The search revealed 3,847 records of which 114 met inclusion criteria and reported clinical data related to 100 patients who underwent 129 VCA transplants. Trauma (50%) and burns (15%) were the most frequent indications for VCA. Of all 114 studies, only one reported

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“…Burn patients with severe facial injury might otherwise be possible candidates for facial VCA, but may have become sensitized during their early burn management. Chandraker et al [8] recently described antibody-mediated rejection within 5 days after face transplantation in a sensitized burn patient.…”

mentioning

confidence: 99%

Evaluation of human leukocyte antigen sensitization in burn patients after treatment with skin allografts and transfusion of blood products

et al. 2017

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Face Transplantation in a Highly Sensitized Recipient

Cited by 4 publications

References 0 publications

Collagen Chitosan Scaffolds on Induced Skin Defect in a Rat Model (An Experimental Study)

Collagen Chitosan Scaffolds on Induced Skin Defect in a Rat Model (An Experimental Study)

Pre-transplant management and sensitisation in vascularised composite allotransplantation: A systematic review

Evaluation of human leukocyte antigen sensitization in burn patients after treatment with skin allografts and transfusion of blood products

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