Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery

Abstract

A zwitterionic sulfobetaine functionalized polyacetal dendrimer presented excellent structural stability, high internalization efficiency, unique pH-responsive drug release behaviors and remarkable antitumor efficacy.

Novel zwitterionic vectors: Multi-functional delivery systems for therapeutic genes and drugs

“…Taking advantages of the acid-labile characteristics of acetal segments, Wang et al fabricated a pH-sensitive SB-modified dendrimer (Gn’-SB) for antitumor drug delivery [93] . Dendrimers are regarded as a novel kind of promising micelle in the field of DDSs owning to the unique merits of uniform architectures, controllable sizes, abundant terminal groups, huge internal cavities, surface functionality and low intrinsic viscosity in solutions [94] .…”

The Role of Tumor Inflammatory Microenvironment in Lung Cancer

“…It mainly includes tumor cells, tumor-associated fibroblasts, immune cells, vascular endothelial cells, extracellular matrix (ECM) and its degrading enzymes, various growth factors, and inflammatory factors. Moreover, it has special physical and chemical characteristics (e.g., hypoxia, low pH) (Wang et al, 2016;Wang et al, 2019;Jiang et al, 2020;Zheng et al, 2020;Liu et al, 2021;Song et al, 2021;Zheng et al, 2021). The TME has multiple effects on tumor initiation, development, and progression, and the mechanism is complex.…”

Schiff-Linked PEGylated Doxorubicin Prodrug Forming pH-Responsive Nanoparticles With High Drug Loading and Effective Anticancer Therapy

“…Wherein, the significance of pH change in the tumor cell environment is recognized as a most popular chemical stimuli to tailor drug release in aqueous solutions. For example, Ding et al developed a cRGD-decorated pH-responsive polyion complex (PIC) micelle for intracellular targeted delivery of DOX to upregulate tumor inhibition and reduce toxicity (28)(29)(30)(31)(32)(33). Although Sui et al had reported a PEG-DOX prodrug with an acid-labile hydrazone bond for cancer chemotherapy, this drug system displayed a weak pH response with approximately 12% release content at pH 5.0 even for 3 days, which may induce the antitumor efficiency in the first place and lose the opportunity for early treatment (26).…”

“…For example, Ding et al. developed a cRGD-decorated pH-responsive polyion complex (PIC) micelle for intracellular targeted delivery of DOX to upregulate tumor inhibition and reduce toxicity ( 28 – 33 ). Although Sui et al.…”