Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering

Chen, Jingxiao; Yuan, Jing; Wu, Yaling; Wang, Ping; Zhao, Peng; Lv, Guozhong; Chen, Jinghua

doi:10.1002/jbm.a.36222

Cited by 28 publications

(20 citation statements)

References 35 publications

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“…PEG is highly unstable because of its ether structure, which can form peroxides ( Thoma et al, 2017 ). In view of this shortcoming, PEG can be block copolymerized with other polymers or grafted to slow down the degradation rate ( Chen et al, 2018 ; Fer et al, 2021 ). Polylactic acid (PLA) is a biodegradable material with good solvent resistance and thermal stability ( Vasilyev et al, 2021 ).…”

Section: Fabrication Strategy Of Peg-based Hydrogelsmentioning

confidence: 99%

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Sun

Cui

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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Drug delivery systems composed of osteogenic substances and biological materials are of great significance in enhancing bone regeneration, and appropriate biological carriers are the cornerstone for their construction. Polyethylene glycol (PEG) is favored in bone tissue engineering due to its good biocompatibility and hydrophilicity. When combined with other substances, the physicochemical properties of PEG-based hydrogels fully meet the requirements of drug delivery carriers. Therefore, this paper reviews the application of PEG-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.

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Section: Fabrication Strategy Of Peg-based Hydrogelsmentioning

confidence: 99%

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Sun

Cui

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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“…These results imply that these tough hydrogels are as tough as natural rubbers [ 83 , 88 , 89 , 90 ]. Many synthetic and natural polymers are used in the preparation of these tough hydrogels such as poly(vinylpyrrolidone) [ 91 ], poly(acrylamide) [ 92 ], poly(acrylic acid) [ 93 ], poly( N -isopropylacrylamide) [ 94 , 95 ], poly(2-acrylamido-2-methylpropanesulfonic acid) [ 82 ], poly(ethylene glycol) [ 96 ], alginate [ 83 ], agarose [ 97 ], and chitosan [ 98 ]. The first generation of double network (DN) hydrogels as reported by Gong and co-workers utilized covalent crosslinkers.…”

Section: Tough Hydrogels With Excellent Load-bearing Performancementioning

confidence: 99%

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Xin

Naficy

2022

Gels

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Breast cancer is the most common and biggest health threat for women. There is an urgent need to develop novel breast cancer therapies to overcome the shortcomings of conventional surgery and chemotherapy, which include poor drug efficiency, damage to normal tissues, and increased side effects. Drug delivery systems based on injectable hydrogels have recently gained remarkable attention, as they offer encouraging solutions for localized, targeted, and controlled drug release to the tumor site. Such systems have great potential for improving drug efficiency and reducing the side effects caused by long-term exposure to chemotherapy. The present review aims to provide a critical analysis of the latest developments in the application of drug delivery systems using stimuli-responsive injectable hydrogels for breast cancer treatment. The focus is on discussing how such hydrogel systems enhance treatment efficacy and incorporate multiple breast cancer therapies into one system, in response to multiple stimuli, including temperature, pH, photo-, magnetic field, and glutathione. The present work also features a brief outline of the recent progress in the use of tough hydrogels. As the breast undergoes significant physical stress and movement during sporting and daily activities, it is important for drug delivery hydrogels to have sufficient mechanical toughness to maintain structural integrity for a desired period of time.

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“…Chen et al fabricated a series of PEG/collagen (PEG/Col) DN hydrogel with significantly enhanced strength and toughness. The results indicated that the PEG/Col DN hydrogels possessed a favorable biocompatibility with a strengthened skeleton, providing an appropriate environment for cell growth in load‐bearing tissue repairing (J. X. Chen et al, ). These approaches would bring DN hydrogels into bone restoration and hard tissue replacement.…”

Section: Dn Hydrogels For Tissue Engineeringmentioning

confidence: 99%

Double network hydrogel for tissue engineering

Huang

Luo

et al. 2018

WIREs Nanomed Nanobiotechnol

129

105

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Double network (DN) hydrogels, a kind of promising soft and tough hydrogels, are produced by two unique contrasting networks with designed network entanglement burst into the field of materials science as versatile functional systems for a very broad range of applications. A part of the DN hydrogels is characterized by extraordinary mechanical properties providing efficient biocompatible and high strength for holding considerable promise in tissue engineering. Following DN hydrogels principles and consideration of biomedical applications, we provide an overall view of the present various DN hydrogels and look forward to the future of DN hydrogels for tissue engineering. In this review, the preparation methods, structure, properties, current situation, and challenges are mainly discussed for the purpose of tissue engineering. This article is categorized under: Implantable Materials and Surgical Technologies > Nanomaterials and Implants Implantable Materials and Surgical Technologies > Nanotechnology in Tissue Repair and Replacement.

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Fabrication of tough poly(ethylene glycol)/collagen double network hydrogels for tissue engineering

Cited by 28 publications

References 35 publications

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Drug Delivery Based on Stimuli-Responsive Injectable Hydrogels for Breast Cancer Therapy: A Review

Double network hydrogel for tissue engineering

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